spacer gif spacer gif spacer gif spacer gif ARCHIVE ANNOUNCEMENT! spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Vavra, S. H.
Right arrow Articles by Carroll, S. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Vavra, S. H.
Right arrow Articles by Carroll, S. B.

Development, Vol 107, Issue 3 663-672, Copyright © 1989 by Company of Biologists

JOURNAL ARTICLES

The zygotic control of Drosophila pair-rule gene expression. I. A search for new pair-rule regulatory loci

SH Vavra and SB Carroll
Laboratory of Molecular Biology, University of Wisconsin, Madison 53706.

The examination of pair-rule gene expression in wild-type and segmentation mutant embryos has identified many, but not necessarily all, of the elements of the regulatory system that establish their periodic patterns. Here we have conducted a new type of search for previously unknown regulators of these genes by examining pair-rule gene expression in blastoderm embryos lacking parts of or entire chromosomes. This method has the advantage of direct inspection of abnormal pair-rule gene patterns without relying upon mutagenesis or interpretation of larval phenotypes for the identification of segmentation genes. From these experiments we conclude that: (i) most zygotically required regulators of the fushi tarazu (ftz), even-skipped (eve) and hairy (h) pair-rule genes have been identified, except for one or more loci we have uncovered on chromosome arm 2L; (ii) the repression of the ftz and eve genes in the anterior third of the embryo is under maternal, not zygotic control; and (iii) there are no general zygotically required activators of pair-rule gene expression. The results suggest that the molecular basis of pair-rule gene regulation can be pursued with greater confidence now that most key trans-acting factors are already in hand.


This article has been cited by other articles:


Home page
 DevelopmentHome page
L. P. M. Andrioli, V. Vasisht, E. Theodosopoulou, A. Oberstein, and S. Small
Anterior repression of a Drosophila stripe enhancer requires three position-specific mechanisms
Development, January 11, 2002; 129(21): 4931 - 4940.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
G. Hewitt, B. Strunk, C Margulies, T Priputin, X. Wang, R Amey, B. Pabst, D Kosman, J Reinitz, and D. Arnosti
Transcriptional repression by the Drosophila giant protein: cis element positioning provides an alternative means of interpreting an effector gradient
Development, January 3, 1999; 126(6): 1201 - 1210.
[Abstract] [PDF]

Home page
 DevelopmentHome page
X Wu, R Vakani, and S Small
Two distinct mechanisms for differential positioning of gene expression borders involving the Drosophila gap protein giant
Development, January 10, 1998; 125(19): 3765 - 3774.
[Abstract] [PDF]


© The Company of Biologists Ltd 1989