|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 108, Issue 1 47-58, Copyright © 1990 by Company of Biologists
JOURNAL ARTICLES |
OH Sundin, HG Busse, MB Rogers, LJ Gudas and G Eichele
Department of Cellular and Molecular Physiology, Harvard Medical School, Boston, MA 02115.
A chick gene homologous to the Drosophila homeobox gene labial has been cloned and sequenced. Regions of additional sequence identity outside of the homeobox reveal a close relationship to the mouse gene Hox 1.6. Northern blot analysis demonstrates that Ghox-lab and Hox 1.6 transcripts are both present at high levels during early stages of chick and mouse development, with a subsequent decline in abundance to very low levels by the time limb mesenchyme begins to differentiate. In situ hybridization analysis of chick embryos shows intense expression of Ghox-lab mRNA by Hamburger and Hamilton stage 4 (avian 'mid gastrula') and by stage 6 (pre-somitic neural plate) with expression decreasing shortly thereafter. The pattern of Ghox-lab RNA expression in these early embryos divides the embryo into an anterior and a posterior compartment. At stage 6, considerable signal is observed in the posterior two thirds of the embryo, while none is detected in the anterior third which is fated to become the head. This pattern is purely regional in nature, and does not follow boundaries defined by known tissue types. In situ hybridization of Hox 1.6 probes to mouse embryos of day 7.5 or 8.0 indicate that the Hox 1.6 transcript has a temporal and spatial distribution very similar to that of Ghox-lab in the chick embryo.
This article has been cited by other articles:
|
|
 |
|
  C. L. McNulty, J. N. Peres, N. Bardine, W. M. R. van den Akker, and A. J. Durston Knockdown of the complete Hox paralogous group 1 leads to dramatic hindbrain and neural crest defects Development, June 15, 2005; 132(12): 2861 - 2871. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Martinez-Ceballos, P. Chambon, and L. J. Gudas Differences in Gene Expression between Wild Type and Hoxa1 Knockout Embryonic Stem Cells after Retinoic Acid Treatment or Leukemia Inhibitory Factor (LIF) Removal J. Biol. Chem., April 22, 2005; 280(16): 16484 - 16498. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Dupe and A. Lumsden Hindbrain patterning involves graded responses to retinoic acid signalling Development, June 15, 2001; 128(12): 2199 - 2208. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Takeda, J.-P. Bonnamy, M. J. Owen, P. Ducy, and G. Karsenty Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient mice Genes & Dev., February 15, 2001; 15(4): 467 - 481. [Abstract] [Full Text]
|
|
|
|
|
|
A. W. Langston, J. R. Thompson, and L. J. Gudas Retinoic Acid-responsive Enhancers Located 3' of the Hox A and Hox B Homeobox Gene Clusters. FUNCTIONAL ANALYSIS J. Biol. Chem., January 24, 1997; 272(4): 2167 - 2175. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Shi, J. H. Winston, M. R. Blackburn, S. K. Datta, G. Hanten, and R. E. Kellems Diverse Genetic Regulatory Motifs Required for Murine Adenosine Deaminase Gene Expression in the Placenta J. Biol. Chem., January 24, 1997; 272(4): 2334 - 2341. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Maden, A Graham, E Gale, C Rollinson, and M Zile Positional apoptosis during vertebrate CNS development in the absence of endogenous retinoids Development, January 7, 1997; 124(14): 2799 - 2805. [Abstract] [PDF]
|
|
|
|
|
|
H. Lu, G Eichele, and C Thaller Ligand-bound RXR can mediate retinoid signal transduction during embryogenesis Development, January 1, 1997; 124(1): 195 - 203. [Abstract] [PDF]
|
|
|
|
|
|
V Dupe, M Davenne, J Brocard, P Dolle, M Mark, A Dierich, P Chambon, and F. Rijli In vivo functional analysis of the Hoxa-1 3' retinoic acid response element (3'RARE) Development, January 1, 1997; 124(2): 399 - 410. [Abstract] [PDF]
|
|
|
|
|
|
A. L. Lewis, O. M. Guicherit, S. K. Datta, G. R. Hanten, and R. E. Kellems Structure and Expression of the Murine Muscle Adenylosuccinate Synthetase Gene J. Biol. Chem., September 13, 1996; 271(37): 22647 - 22656. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Galera, R.-W. Park, P. Ducy, M.-G. Mattei, and G. Karsenty c-Krox Binds to Several Sites in the Promoter of Both Mouse Type I Collagen Genes. STRUCTURE/FUNCTION STUDY AND DEVELOPMENTAL EXPRESSION ANALYSIS J. Biol. Chem., August 30, 1996; 271(35): 21331 - 21339. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B Lutz, H C Lu, G Eichele, D Miller, and T C Kaufman Rescue of Drosophila labial null mutant by the chicken ortholog Hoxb-1 demonstrates that the function of Hox genes is phylogenetically conserved. Genes & Dev., January 15, 1996; 10(2): 176 - 184. [Abstract] [PDF]
|
|
|
|
|
|
H Zhang and A Bradley Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development Development, January 10, 1996; 122(10): 2977 - 2986. [Abstract] [PDF]
|
|
|
|
|
|
J. Helms, C. Kim, G Eichele, and C Thaller Retinoic acid signaling is required during early chick limb development Development, January 5, 1996; 122(5): 1385 - 1394. [Abstract] [PDF]
|
|
|
|
|
|
E Gale, V Prince, A Lumsden, J Clarke, N Holder, and M Maden Late effects of retinoic acid on neural crest and aspects of rhombomere Development, January 3, 1996; 122(3): 783 - 793. [Abstract] [PDF]
|
|
|
|
|
|
E Hermesz, S Mackem, and K. Mahon Rpx: a novel anterior-restricted homeobox gene progressively activated in the prechordal plate, anterior neural plate and Rathke's pouch of the mouse embryo Development, January 1, 1996; 122(1): 41 - 52. [Abstract] [PDF]
|
|
|
|
|
|
G Luo, C Hofmann, A L Bronckers, M Sohocki, A Bradley, and G Karsenty BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning. Genes & Dev., November 15, 1995; 9(22): 2808 - 2820. [Abstract] [PDF]
|
|
|
|
 |
|
 S. Parker, G Eichele, P Zhang, A Rawls, A. Sands, A Bradley, E. Olson, J. Harper, and S. Elledge p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells Science, February 17, 1995; 267(5200): 1024 - 1027. [Abstract] [PDF]
|
|
|
|
|
|
Y Katsuyama, S Wada, S Yasugi, and H Saiga Expression of the labial group Hox gene HrHox-1 and its alteration induced by retinoic acid in development of the ascidian Halocynthia roretzi Development, January 10, 1995; 121(10): 3197 - 3205. [Abstract] [PDF]
|
|
|
|
|
|
M Frasch, X Chen, and T Lufkin Evolutionary-conserved enhancers direct region-specific expression of the murine Hoxa-1 and Hoxa-2 loci in both mice and Drosophila Development, January 4, 1995; 121(4): 957 - 974. [Abstract] [PDF]
|
|
|
|
|
|
M. Robinson, P. Overbeek, D. Verran, W. Grizzle, C. Stockard, R Friesel, T Maciag, and J. Thompson Extracellular FGF-1 acts as a lens differentiation factor in transgenic mice Development, January 2, 1995; 121(2): 505 - 514. [Abstract] [PDF]
|
|
|
|
|
|
J Helms, C Thaller, and G Eichele Relationship between retinoic acid and sonic hedgehog, two polarizing signals in the chick wing bud Development, January 11, 1994; 120(11): 3267 - 3274. [Abstract] [PDF]
|
|
|
|
|
|
C. R. Hume and J. Dodd Cwnt-8C: a novel Wnt gene with a potential role in primitive streak formation and hindbrain organization Development, December 1, 1993; 119(4): 1147 - 1160. [Abstract] [PDF]
|
|
|
|
|
|
A Frumkin, R Haffner, E Shapira, N Tarcic, Y Gruenbaum, and A Fainsod The chicken CdxA homeobox gene and axial positioning during gastrulation Development, January 6, 1993; 118(2): 553 - 562. [Abstract] [PDF]
|
|
|
|
|
|
M. Frohman, G. Martin, S. Cordes, L. Halamek, and G. Barsh Altered rhombomere-specific gene expression and hyoid bone differentiation in the mouse segmentation mutant, kreisler (kr) Development, January 3, 1993; 117(3): 925 - 936. [Abstract] [PDF]
|
|
|
|
|
|
B. Meyer and P Gruss Mouse Cdx-1 expression during gastrulation Development, January 1, 1993; 117(1): 191 - 203. [Abstract] [PDF]
|
|
|
|
|
|
A. F. Candia, J. Hu, J. Crosby, P. A. Lalley, D. Noden, J. H. Nadeau, and C. V. Wright Mox-1 and Mox-2 define a novel homeobox gene subfamily and are differentially expressed during early mesodermal patterning in mouse embryos Development, December 1, 1992; 116(4): 1123 - 1136. [Abstract] [PDF]
|
|
|
|
|
|
H L Sive and P F Cheng Retinoic acid perturbs the expression of Xhox.lab genes and alters mesodermal determination in Xenopus laevis. Genes & Dev., August 1, 1991; 5(8): 1321 - 1332. [Abstract] [PDF]
|
|
|
|
|
|
B Blumberg, C. Wright, E. De Robertis, and K. Cho Organizer-specific homeobox genes in Xenopus laevis embryos Science, July 12, 1991; 253(5016): 194 - 196. [Abstract] [PDF]
|
|
|
|
|
|
O H Sundin and G Eichele A homeo domain protein reveals the metameric nature of the developing chick hindbrain. Genes & Dev., August 1, 1990; 4(8): 1267 - 1276. [Abstract] [PDF]
|
|
|
|
|
|
H L Sive, B W Draper, R M Harland, and H Weintraub Identification of a retinoic acid-sensitive period during primary axis formation in Xenopus laevis. Genes & Dev., June 1, 1990; 4(6): 932 - 942. [Abstract] [PDF]
|
|
