|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 109, Issue 4 743-752, Copyright © 1990 by Company of Biologists
JOURNAL ARTICLES |
O Pourquie, M Coltey, JL Thomas and NM Le Douarin
Institut d'embryologie cellulaire et moleculaire du CNRS et du College de France, Nogent sur Marne.
We have identified a glycoprotein (BEN) of 95-100 x 10(3) Mr using a monoclonal antibody. This protein is transiently expressed at the cell surface of the peripherally projecting neurons, i.e. motoneurons of the spinal cord and cranial nuclei, sensory neurons of the dorsal root and cranial sensory ganglia and sympathetic, parasympathetic and enteric neurons. In vitro cultures of dorsal root and sympathetic ganglia have shown that BEN is expressed on neurons but not on glial cells. On motor and sensory neurons, BEN first appears at the level of the cell body just after withdrawal from the cell cycle. Soon afterwards, expression of the antigen extends to the elongating axon. After a few days, BEN is no longer expressed by the motor and sensory neurons, disappearing first from the cell body and then progressively from the fibres. The loss of expression is concomitant with the onset of intense proliferation of satellite and Schwann cells. This modulated expression within the nervous system is unlike that of any surface glycoprotein so far described in vertebrates. Preliminary biochemical analysis indicates that, although it bears the adhesion-associated epitope HNK-1, BEN does not share characteristics with any previously described axonal glycoprotein. Consequently, we speculate that this glycoprotein might be a novel molecule implicated in selective adhesion phenomena, such as axonal fasciculation.
This article has been cited by other articles:
|
|
 |
|
  K. Ikeda and T. Quertermous Molecular Isolation and Characterization of a Soluble Isoform of Activated Leukocyte Cell Adhesion Molecule That Modulates Endothelial Cell Function J. Biol. Chem., December 31, 2004; 279(53): 55315 - 55323. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-C. Delfini and D. Duprez Ectopic Myf5 or MyoD prevents the neuronal differentiation program in addition to inducing skeletal muscle differentiation, in the chick neural tube Development, February 15, 2004; 131(4): 713 - 723. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Irving, A. Malhas, S. Guthrie, and I. Mason Establishing the trochlear motor axon trajectory: role of the isthmic organiser and Fgf8 Development, January 12, 2002; 129(23): 5389 - 5398. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Ohneda, K. Ohneda, F. Arai, J. Lee, T. Miyamoto, Y. Fukushima, D. Dowbenko, L. A. Lasky, and T. Suda ALCAM (CD166): its role in hematopoietic and endothelial development Blood, October 1, 2001; 98(7): 2134 - 2142. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Konno, J.-S. Ahn, H. Kitamura, M. J. Hamilton, J. A. Gebe, A. Aruffo, and W. C. Davis Tissue distribution of CD6 and CD6 ligand in cattle: expression of the CD6 ligand (CD166) in the autonomic nervous system of cattle and the human J. Leukoc. Biol., June 1, 2001; 69(6): 944 - 950. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C Soula, C Danesin, P Kan, M Grob, C Poncet, and P Cochard Distinct sites of origin of oligodendrocytes and somatic motoneurons in the chick spinal cord: oligodendrocytes arise from Nkx2.2-expressing progenitors by a Shh-dependent mechanism Development, January 4, 2001; 128(8): 1369 - 1379. [Abstract] [PDF]
|
|
|
|
 |
|
 D. S. Heffron and J. A. Golden DM-GRASP Is Necessary for Nonradial Cell Migration during Chick Diencephalic Development J. Neurosci., March 15, 2000; 20(6): 2287 - 2294. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Bell, R. J. Wingate, and A. Lumsden Homeotic Transformation of Rhombomere Identity After Localized Hoxb1 Misexpression Science, June 25, 1999; 284(5423): 2168 - 2171. [Abstract] [Full Text]
|
|
|
|
|
|
E. Bloch-Gallego, F. Ezan, M. Tessier-Lavigne, and C. Sotelo Floor Plate and Netrin-1 Are Involved in the Migration and Survival of Inferior Olivary Neurons J. Neurosci., June 1, 1999; 19(11): 4407 - 4420. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Fournier-Thibault, O. Pourquie, T. Rouaud, and N. M. Le Douarin BEN/SC1/DM-GRASP Expression during Neuromuscular Development: a Cell Adhesion Molecule Regulated by Innervation J. Neurosci., February 15, 1999; 19(4): 1382 - 1392. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Cortes, F. Deschaseaux, N. Uchida, M.-C. Labastie, A. M. Friera, D. He, P. Charbord, and B. Peault HCA, an Immunoglobulin-Like Adhesion Molecule Present on the Earliest Human Hematopoietic Precursor Cells, Is Also Expressed by Stromal Cells in Blood-Forming Tissues Blood, February 1, 1999; 93(3): 826 - 837. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S Jungbluth, E Bell, and A Lumsden Specification of distinct motor neuron identities by the singular activities of individual Hox genes Development, January 6, 1999; 126(12): 2751 - 2758. [Abstract] [PDF]
|
|
|
|
|
|
N. Uchida, Z. Yang, J. Combs, O. Pourquie, M. Nguyen, R. Ramanathan, J. Fu, A. Welply, S. Chen, G. Weddell, et al. The Characterization, Molecular Cloning, and Expression of a Novel Hematopoietic Cell Antigen From CD34+ Human Bone Marrow Cells Blood, April 15, 1997; 89(8): 2706 - 2716. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A Varela-Echavarria and S Guthrie Molecules making waves in axon guidance. Genes & Dev., March 1, 1997; 11(5): 545 - 557. [PDF]
|
|
|
|
|
|
B. Williams and C. Ordahl Emergence of determined myotome precursor cells in the somite Development, January 12, 1997; 124(24): 4983 - 4997. [Abstract] [PDF]
|
|
|
|
|
|
J. Martinez-Morales, J. Barbas, E Marti, P Bovolenta, D Edgar, and A Rodriguez-Tebar Vitronectin is expressed in the ventral region of the neural tube and promotes the differentiation of motor neurons Development, January 12, 1997; 124(24): 5139 - 5147. [Abstract] [PDF]
|
|
|
|
|
|
A Grapin-Botton, M. Bonnin, and N. Le Douarin Hox gene induction in the neural tube depends on three parameters: competence, signal supply and paralogue group Development, January 2, 1997; 124(4): 849 - 859. [Abstract] [PDF]
|
|
|
|
|
|
A. Chedotal, O. Pourquie, F. Ezan, H. San Clemente, and C. Sotelo BEN As a Presumptive Target Recognition Molecule during the Development of the Olivocerebellar System J. Neurosci., May 15, 1996; 16(10): 3296 - 3310. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S Gobron, H Monnerie, R Meiniel, I Creveaux, W Lehmann, D Lamalle, B Dastugue, and A Meiniel SCO-spondin: a new member of the thrombospondin family secreted by the subcommissural organ is a candidate in the modulation of neuronal aggregation J. Cell Sci., January 5, 1996; 109(5): 1053 - 1061. [Abstract] [PDF]
|
|
|
|
|
|
F Cormier Avian pluripotent haemopoietic progenitor cells: detection and enrichment from the para-aortic region of the early embryo J. Cell Sci., January 7, 1993; 105(3): 661 - 666. [Abstract] [PDF]
|
|
|
|
|
|
P. Rong, M. Teillet, C Ziller, and N. Le Douarin The neural tube/notochord complex is necessary for vertebral but not limb and body wall striated muscle differentiation Development, January 7, 1992; 115(3): 657 - 672. [Abstract] [PDF]
|
|
