|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 109, Issue 4 775-786, Copyright © 1990 by Company of Biologists
JOURNAL ARTICLES |
C Kress, R Vogels, W De Graaff, C Bonnerot, F Meijlink, JF Nicolas and J Deschamps
Unite de Biologie Cellulaire de Developpement, Institut Pasteur, Paris, France.
The mouse Hox-2.3 gene contains an Antp-like homeobox sequence and is expressed in a spatially restricted anteroposterior domain during development. To study the molecular basis of this differential gene regulation, we set out to characterize the cis-regulatory elements mediating Hox-2.3 expression during embryogenesis. We show that a fragment extending 1316 base pairs (bp) upstream of the transcription start site, thus corresponding to the Hox-2.4/Hox-2.3 intergenic sequences is capable of mediating luciferase gene transcription in transfected cells in vitro and lacZ expression in transgenic mice. The beta-galactosidase-staining pattern in embryos was found to be strikingly similar to the Hox-2.3 in situ hybridization pattern in intermediate mesoderm derivatives: high levels of both Hox-2.3 transcripts and beta-galactosidase activity were found in the mesonephric duct-derived epithelium of the meso- and metanephric kidney and associated ducts, from the time these structures first appeared on throughout development. The transgene apparently lacks sequences needed for correct Hox-2.3 expression in somitic and lateral plate mesoderm and in neurectoderm. These results document the involvement of distinct regulatory elements in Hox gene expression in subsets of cells with distinct developmental fate, situated at similar positions along the anteroposterior axis of the embryo.
This article has been cited by other articles:
|
|
 |
|
  A. van de Stolpe, A. J. Slycke, M. O. Reinders, A. W. M. Zomer, S. Goodenough, C. Behl, A. F. Seasholtz, and P. T. van der Saag Estrogen Receptor (ER)-Mediated Transcriptional Regulation of the Human Corticotropin-Releasing Hormone-Binding Protein Promoter: Differential Effects of ER{alpha} and ER{beta} Mol. Endocrinol., December 1, 2004; 18(12): 2908 - 2923. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. H. Yu, I. J. Murawski, D. B. Myburgh, and I. R. Gupta Overexpression of RET leads to vesicoureteric reflux in mice Am J Physiol Renal Physiol, December 1, 2004; 287(6): F1123 - F1130. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. C. Hu, T. D. Piscione, and N. D. Rosenblum Elevated SMAD1/{beta}-catenin molecular complexes and renal medullary cystic dysplasia in ALK3 transgenic mice Development, June 15, 2003; 130(12): 2753 - 2766. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Yu, T. J. Carroll, and A. P. McMahon Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney Development, March 13, 2003; 129(22): 5301 - 5312. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Puttini, A. T. Beggah, A. Ouvrard-Pascaud, C. Legris, M. Blot-Chabaud, N. Farman, and F. Jaisser Tetracycline-inducible gene expression in cultured rat renal CD cells and in intact CD from transgenic mice Am J Physiol Renal Physiol, December 1, 2001; 281(6): F1164 - F1172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S Srinivas, Z Wu, C. Chen, V D'Agati, and F Costantini Dominant effects of RET receptor misexpression and ligand-independent RET signaling on ureteric bud development Development, January 4, 1999; 126(7): 1375 - 1386. [Abstract] [PDF]
|
|
|
|
 |
|
 E. Caldenhoven STAT3beta , a Splice Variant of Transcription Factor STAT3, Is a Dominant Negative Regulator of Transcription J. Biol. Chem., May 24, 1996; 271(22): 13221 - 13227. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L.-N. Wei and L. Chang Promoter and Upstream Regulatory Activities of the Mouse Cellular Retinoic Acid-binding Protein-I Gene J. Biol. Chem., March 1, 1996; 271(9): 5073 - 5078. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F Bernex, P De Sepulveda, C Kress, C Elbaz, C Delouis, and J. Panthier Spatial and temporal patterns of c-kit-expressing cells in WlacZ/+ and WlacZ/WlacZ mouse embryos Development, January 10, 1996; 122(10): 3023 - 3033. [Abstract] [PDF]
|
|
|
|
|
|
A Morrison, M. Moroni, L Ariza-McNaughton, R Krumlauf, and F Mavilio In vitro and transgenic analysis of a human HOXD4 retinoid-responsive enhancer Development, January 6, 1996; 122(6): 1895 - 1907. [Abstract] [PDF]
|
|
|
|
|
|
E. Caldenhoven, T. van Dijk, J. A. M. Raaijmakers, J.-W. J. Lammers, L. Koenderman, and R. P. de Groot Activation of the STAT3/Acute Phase Response Factor Transcription Factor by Interleukin-5 J. Biol. Chem., October 27, 1995; 270(43): 25778 - 25784. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Frasch, X Chen, and T Lufkin Evolutionary-conserved enhancers direct region-specific expression of the murine Hoxa-1 and Hoxa-2 loci in both mice and Drosophila Development, January 4, 1995; 121(4): 957 - 974. [Abstract] [PDF]
|
|
|
|
|
|
T Knittel, M Kessel, M. Kim, and P Gruss A conserved enhancer of the human and murine Hoxa-7 gene specifies the anterior boundary of expression during embryonal development Development, January 4, 1995; 121(4): 1077 - 1088. [Abstract] [PDF]
|
|
|
|
 |
|
 A. Berns, N. van der Lugt, M. Alkema, M. van Lohuizen, J. Domen, D. Acton, J. Allen, P.W. Laird, and J. Jonkers Mouse Model Systems to Study Multistep Tumorigenesis Cold Spring Harb Symp Quant Biol, January 1, 1994; 59(0): 435 - 447. [Abstract] [PDF]
|
|
|
|
|
|
M Oosterwegel, M van de Wetering, J Timmerman, A Kruisbeek, O Destree, F Meijlink, and H Clevers Differential expression of the HMG box factors TCF-1 and LEF-1 during murine embryogenesis Development, January 6, 1993; 118(2): 439 - 448. [Abstract] [PDF]
|
|
|
|
|
|
R Vogels, J Charite, W de Graaff, and J Deschamps Proximal cis-acting elements cooperate to set Hoxb-7 (Hox-2.3) expression boundaries in transgenic mice Development, January 5, 1993; 118(1): 71 - 82. [Abstract] [PDF]
|
|
|
|
|
|
R. Behringer, D. Crotty, V. Tennyson, R. Brinster, R. Palmiter, and D. Wolgemuth Sequences 5' of the homeobox of the Hox-1.4 gene direct tissue-specific expression of lacZ during mouse development Development, January 3, 1993; 117(3): 823 - 833. [Abstract] [PDF]
|
|
|
|
|
|
C Logan, W. Khoo, D Cado, and A. Joyner Two enhancer regions in the mouse En-2 locus direct expression to the mid/hindbrain region and mandibular myoblasts Development, January 3, 1993; 117(3): 905 - 916. [Abstract] [PDF]
|
|
|
|
 |
|
 J Whiting, H Marshall, M Cook, R Krumlauf, P W Rigby, D Stott, and R K Allemann Multiple spatially specific enhancers are required to reconstruct the pattern of Hox-2.6 gene expression. Genes & Dev., November 1, 1991; 5(11): 2048 - 2059. [Abstract] [PDF]
|
|
