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Development, Vol 110, Issue 3 839-849, Copyright © 1990 by Company of Biologists

JOURNAL ARTICLES

Masculinizing effect of testes on developing rat ovaries in organ culture

G Charpentier and S Magre
Laboratoire de Physiologie du Developpement, College de France, Paris.

Masculinizing effect of testes on developing rat ovaries was shown in vitro by culturing testes from 17.5-day-old fetuses in contact with female genital tracts from 14.5-day-old rat fetuses. The testes induced the differentiation of epithelial cells staining for cytokeratin in the ovarian blastema. These cells formed seminiferous cord-like structures delineated by a basement membrane, in a way that resembles early stages of testicular organogenesis. In addition to the morphological masculinization, functional masculinization was obtained since the ovaries produced the anti-Mullerian hormone as shown by bioassay and immunohistochemical procedures. Across a distance, testes from 17.5-day-old fetuses failed to induce masculinization. These results suggest that testes from 17.5-day-old fetuses produce a locally diffusible factor interfering with the development and the differentiation of the fetal ovaries. The possibility that the anti-Mullerian hormone secreted by the testes may be the factor involved is discussed comparing these results with those obtained with testes from different stages and with bibliographic data.


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© The Company of Biologists Ltd 1990