spacer gif spacer gif spacer gif spacer gif ARCHIVE ANNOUNCEMENT! spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fisher, C.
Right arrow Articles by Powers, E. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fisher, C.
Right arrow Articles by Powers, E. A.

Development, Vol 111, Issue 2 253-258, Copyright © 1991 by Company of Biologists

JOURNAL ARTICLES

Patterns of epithelial expression of Fos protein suggest important role in the transition from viable to cornified cell during keratinization

C Fisher, MR Byers, MJ Iadarola and EA Powers
Upjohn Company, Kalamazoo, MI 49001.

An antibody directed against the DNA-binding region of c-fos was used to localize the distribution of cells positive for Fos protein in epithelial tissues. The antibody consistently bound to the nuclei of epithelial cells in the late stages of differentiation, just prior to cornification. The epidermis, palate, buccal mucosa, gingiva, tongue, forestomach and vagina in estrus all produced this type of labelling, suggesting a burst of expression immediately before cell death and cornification. The differentiating cells of the hair follicle, including the hair and inner root sheath, were also labelled. Non-keratinized tissues including junctional epithelium, embryonic epidermis and diestrus vaginal epithelium showed little or no Fos labelling. With the onset of keratinization at 18 days gestation or with induction of estrus in ovariectomized mice with estradiol benzoate, the epidermis and vagina expressed Fos protein in the manner typical for keratinized tissues. The Er/Er mutant epidermis, a tissue that is blocked in its ability to keratinize, overexpresses Fos with Fos-positive cells appearing in virtually every cell layer. Gel shift analysis demonstrates the presence of a functional AP-1 complex in epidermal extracts that is recognized by our antibody. Our data suggest that the expression of Fos is intricately related to epithelial cell differentiation, specifically in relation to the process of cornification and cell death.


This article has been cited by other articles:


Home page
 J. Dent. Res.Home page
K. Amano, K. Miyake, J.L. Borke, and P.L. McNeil
Breaking Biological Barriers with a Toothbrush
J. Dent. Res., August 1, 2007; 86(8): 769 - 774.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M.-C. Chang, H.-L. Wu, J.-J. Lee, P.-H. Lee, H.-H. Chang, L.-J. Hahn, B.-R. Lin, Y.-J. Chen, and J.-H. Jeng
The Induction of Prostaglandin E2 Production, Interleukin-6 Production, Cell Cycle Arrest, and Cytotoxicity in Primary Oral Keratinocytes and KB Cancer Cells by Areca Nut Ingredients Is Differentially Regulated by MEK/ERK Activation
J. Biol. Chem., December 3, 2004; 279(49): 50676 - 50683.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
S. Nishikawa
Localization of Transcription Factor AP-1 Family Proteins in Ameloblast Nuclei of the Rat Incisor
J. Histochem. Cytochem., November 1, 2000; 48(11): 1511 - 1520.
[Abstract] [Full Text]

Home page
 Cancer Res.Home page
S. E. Rutberg, T. L. Adams, A. Glick, M. T. Bonovich, C. Vinson, and S. H. Yuspa
Activator Protein 1 Transcription Factors Are Fundamental to v-rasHa-induced Changes in Gene Expression in Neoplastic Keratinocytes
Cancer Res., November 1, 2000; 60(22): 6332 - 6338.
[Abstract] [Full Text]

Home page
 Mol. Cell. Biol.Home page
S. Zhu, H.-S. Oh, M. Shim, E. Sterneck, P. F. Johnson, and R. C. Smart
C/EBPbeta Modulates the Early Events of Keratinocyte Differentiation Involving Growth Arrest and Keratin 1 and Keratin 10 Expression
Mol. Cell. Biol., October 1, 1999; 19(10): 7181 - 7190.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
M. Sokolowski, H. Furneaux, and S. Schwartz
The Inhibitory Activity of the AU-Rich RNA Element in the Human Papillomavirus Type 1 Late 3' Untranslated Region Correlates with Its Affinity for the elav-Like HuR Protein
J. Virol., February 1, 1999; 73(2): 1080 - 1091.
[Abstract] [Full Text]

Home page
 J. Virol.Home page
M. Sokolowski, W. Tan, M. Jellne, and S. Schwartz
mRNA Instability Elements in the Human Papillomavirus Type 16 L2 Coding Region
J. Virol., February 1, 1998; 72(2): 1504 - 1515.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. F. Welter, J. F. Crish, C. Agarwal, and R. L. Eckert
Fos-related Antigen (Fra-1), junB, and junD Activate Human Involucrin Promoter Transcription by Binding to Proximal and Distal AP1 Sites to Mediate Phorbol Ester Effects on Promoter Activity
J. Biol. Chem., May 26, 1995; 270(21): 12614 - 12622.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. DiSepio, A. Jones, M. A. Longley, D. Bundman, J. A. Rothnagel, and D. R. Roop
The Proximal Promoter of the Mouse Loricrin Gene Contains a Functional AP-1 Element and Directs Keratinocyte-specific but Not Differentiation-specific Expression
J. Biol. Chem., May 5, 1995; 270(18): 10792 - 10799.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 1991