spacer gif spacer gif spacer gif spacer gif ARCHIVE ANNOUNCEMENT! spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wiles, M. V.
Right arrow Articles by Keller, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wiles, M. V.
Right arrow Articles by Keller, G.

Development, Vol 111, Issue 2 259-267, Copyright © 1991 by Company of Biologists

JOURNAL ARTICLES

Multiple hematopoietic lineages develop from embryonic stem (ES) cells in culture

MV Wiles and G Keller
Basel Institute for Immunology, Postfach, Switzerland.

When embryonic stem cells are cultured directly in semisolid media (methyl cellulose), they proliferate and differentiate to generate colonies known as embryoid bodies (EBs). These EBs consist of differentiated cells from a number of lineages including those of the hematopoietic system. Following 10 days of culture in the presence of 10% fetal calf serum, more than 40% of all EBs from three different ES cell lines, CCEG2, D3 and SQ1.2S8 contained visible erythropoietic cells (i.e. red with hemoglobin). Beta H1 (z globin) mRNA is detectable in EBs within 5 days of differentiation, whilst beta(maj)-globin RNA appears by day 6. In the presence of erythropoietin (Epo), the frequency of EBs with erythropoietic activity increases to greater than 60%; Epo also prolongs this erythropoietic activity. Interleukin-3 (IL-3) does not significantly increase the frequency of EBs that contain erythroid cells, but increases slightly the number of erythropoietic cells associated with them. In the presence of IL-3, in addition to cells of the erythroid lineage, macrophages, mast cells and in some instances neutrophils are found within differentiating EBs. The development of macrophages is significantly enhanced by the addition of IL-3 alone or in combination with IL-1 and M-CSF or GM-CSF. When well-differentiated EBs are allowed to attach onto tissue-culture plates and grown in the presence of IL-3, a long-term output of cells from the mast cell lineage is observed.(ABSTRACT TRUNCATED AT 250 WORDS)


This article has been cited by other articles:


Home page
 Stem CellsHome page
F. Sharifpanah, M. Wartenberg, M. Hannig, H.-M. Piper, and H. Sauer
Peroxisome Proliferator-Activated Receptor {alpha} Agonists Enhance Cardiomyogenesis of Mouse ES Cells by Utilization of a Reactive Oxygen Species-Dependent Mechanism
Stem Cells, January 1, 2008; 26(1): 64 - 71.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. W. McCool, X. Xu, D. B. Singer, F. E. Murdoch, and M. K. Fritsch
The Role of Histone Acetylation in Regulating Early Gene Expression Patterns during Early Embryonic Stem Cell Differentiation
J. Biol. Chem., March 2, 2007; 282(9): 6696 - 6706.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
M.-S. E. M. Mpollo, M. Beaudoin, P. E. Berg, H. Beauchemin, V. D'Agati, and M. Trudel
BP1 is a negative modulator of definitive erythropoiesis
Nucleic Acids Res., October 6, 2006; (2006) gkl680v2.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
V. Camara-Clayette, F. Le Pesteur, W. Vainchenker, and F. Sainteny
Quantitative Oct4 Overproduction in Mouse Embryonic Stem Cells Results in Prolonged Mesoderm Commitment During Hematopoietic Differentiation In Vitro
Stem Cells, August 1, 2006; 24(8): 1937 - 1945.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
A. S. Narang and R. I. Mahato
Biological and biomaterial approaches for improved islet transplantation.
Pharmacol. Rev., June 1, 2006; 58(2): 194 - 243.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
K. Umeda, T. Heike, M. Yoshimoto, G. Shinoda, M. Shiota, H. Suemori, H. Y. Luo, D. H. K. Chui, R. Torii, M. Shibuya, et al.
Identification and Characterization of Hemoangiogenic Progenitors During Cynomolgus Monkey Embryonic Stem Cell Differentiation
Stem Cells, May 1, 2006; 24(5): 1348 - 1358.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. W. Lensch and G. Q. Daley
Scientific and clinical opportunities for modeling blood disorders with embryonic stem cells
Blood, April 1, 2006; 107(7): 2605 - 2612.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
A. L. Olsen, D. L. Stachura, and M. J. Weiss
Designer blood: creating hematopoietic lineages from embryonic stem cells
Blood, February 15, 2006; 107(4): 1265 - 1275.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Pilat, S. Carotta, B. Schiedlmeier, K. Kamino, A. Mairhofer, E. Will, U. Modlich, P. Steinlein, W. Ostertag, C. Baum, et al.
HOXB4 enforces equivalent fates of ES-cell-derived and adult hematopoietic cells
PNAS, August 23, 2005; 102(34): 12101 - 12106.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
E. T. Zambidis, B. Peault, T. S. Park, F. Bunz, and C. I. Civin
Hematopoietic differentiation of human embryonic stem cells progresses through sequential hematoendothelial, primitive, and definitive stages resembling human yolk sac development
Blood, August 1, 2005; 106(3): 860 - 870.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
T. B. Feyerabend, H. Hausser, A. Tietz, C. Blum, L. Hellman, A. H. Straus, H. K. Takahashi, E. S. Morgan, A. M. Dvorak, H. J. Fehling, et al.
Loss of Histochemical Identity in Mast Cells Lacking Carboxypeptidase A
Mol. Cell. Biol., July 15, 2005; 25(14): 6199 - 6210.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
T. Fujikawa, S.-H. Oh, L. Pi, H. M. Hatch, T. Shupe, and B. E. Petersen
Teratoma Formation Leads to Failure of Treatment for Type I Diabetes Using Embryonic Stem Cell-Derived Insulin-Producing Cells
Am. J. Pathol., June 1, 2005; 166(6): 1781 - 1791.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
N. R. D. Paling and M. J. Welham
Tyrosine phosphatase SHP-1 acts at different stages of development to regulate hematopoiesis
Blood, June 1, 2005; 105(11): 4290 - 4297.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
H. S. Keirstead, G. Nistor, G. Bernal, M. Totoiu, F. Cloutier, K. Sharp, and O. Steward
Human Embryonic Stem Cell-Derived Oligodendrocyte Progenitor Cell Transplants Remyelinate and Restore Locomotion after Spinal Cord Injury
J. Neurosci., May 11, 2005; 25(19): 4694 - 4705.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
A. M. Wobus and K. R. Boheler
Embryonic Stem Cells: Prospects for Developmental Biology and Cell Therapy
Physiol Rev, April 1, 2005; 85(2): 635 - 678.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
C. Coraux, B. Nawrocki-Raby, J. Hinnrasky, C. Kileztky, D. Gaillard, C. Dani, and E. Puchelle
Embryonic Stem Cells Generate Airway Epithelial Tissue
Am. J. Respir. Cell Mol. Biol., February 1, 2005; 32(2): 87 - 92.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
W. J. Zhang, C. Park, E. Arentson, and K. Choi
Modulation of hematopoietic and endothelial cell differentiation from mouse embryonic stem cells by different culture conditions
Blood, January 1, 2005; 105(1): 111 - 114.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
S. Arnhold, H. Klein, I. Semkova, K. Addicks, and U. Schraermeyer
Neurally Selected Embryonic Stem Cells Induce Tumor Formation after Long-Term Survival following Engraftment into the Subretinal Space
Invest. Ophthalmol. Vis. Sci., December 1, 2004; 45(12): 4251 - 4255.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
F. Paglialunga, A. Fico, I. Iaccarino, R. Notaro, L. Luzzatto, G. Martini, and S. Filosa
G6PD is indispensable for erythropoiesis after the embryonic-adult hemoglobin switch
Blood, November 15, 2004; 104(10): 3148 - 3152.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
M. Jackson, A. Krassowska, N. Gilbert, T. Chevassut, L. Forrester, J. Ansell, and B. Ramsahoye
Severe Global DNA Hypomethylation Blocks Differentiation and Induces Histone Hyperacetylation in Embryonic Stem Cells
Mol. Cell. Biol., October 15, 2004; 24(20): 8862 - 8871.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
S. Carotta, S. Pilat, A. Mairhofer, U. Schmidt, H. Dolznig, P. Steinlein, and H. Beug
Directed differentiation and mass cultivation of pure erythroid progenitors from mouse embryonic stem cells
Blood, September 15, 2004; 104(6): 1873 - 1880.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
K. Umeda, T. Heike, M. Yoshimoto, M. Shiota, H. Suemori, H. Y. Luo, D. H. K. Chui, R. Torii, M. Shibuya, N. Nakatsuji, et al.
Development of primitive and definitive hematopoiesis from nonhuman primate embryonic stem cells in vitro
Development, April 15, 2004; 131(8): 1869 - 1879.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
R. K. Burt, L. Verda, D.-A. Kim, Y. Oyama, K. Luo, and C. Link
Embryonic Stem Cells As an Alternate Marrow Donor Source: Engraftment without Graft-Versus-Host Disease
J. Exp. Med., April 5, 2004; 199(7): 895 - 904.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
A. T. Clark, M. S. Bodnar, M. Fox, R. T. Rodriquez, M. J. Abeyta, M. T. Firpo, and R. A. R. Pera
Spontaneous differentiation of germ cells from human embryonic stem cells in vitro
Hum. Mol. Genet., April 1, 2004; 13(7): 727 - 739.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
J. G. Lieber, S. Webb, B. T. Suratt, S. K. Young, G. L. Johnson, G. M. Keller, and G. S. Worthen
The in vitro production and characterization of neutrophils from embryonic stem cells
Blood, February 1, 2004; 103(3): 852 - 859.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
A. S. Bailey, S. Jiang, M. Afentoulis, C. I. Baumann, D. A. Schroeder, S. B. Olson, M. H. Wong, and W. H. Fleming
Transplanted adult hematopoietic stems cells differentiate into functional endothelial cells
Blood, January 1, 2004; 103(1): 13 - 19.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
B. Shrestha, D. Gottlieb, and M. S. Diamond
Infection and Injury of Neurons by West Nile Encephalitis Virus
J. Virol., December 15, 2003; 77(24): 13203 - 13213.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
J. H. Park, S. J. Kim, E. J. Oh, S. Y. Moon, S. I. Roh, C. G. Kim, and H. S. Yoon
Establishment and Maintenance of Human Embryonic Stem Cells on STO, a Permanently Growing Cell Line
Biol Reprod, December 1, 2003; 69(6): 2007 - 2014.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
K. Chadwick, L. Wang, L. Li, P. Menendez, B. Murdoch, A. Rouleau, and M. Bhatia
Cytokines and BMP-4 promote hematopoietic differentiation of human embryonic stem cells
Blood, August 1, 2003; 102(3): 906 - 915.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
S. Ooto, M. Haruta, Y. Honda, H. Kawasaki, Y. Sasai, and M. Takahashi
Induction of the Differentiation of Lentoids from Primate Embryonic Stem Cells
Invest. Ophthalmol. Vis. Sci., June 1, 2003; 44(6): 2689 - 2693.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
R. Passier and C. Mummery
Origin and use of embryonic and adult stem cells in differentiation and tissue repair
Cardiovasc Res, May 1, 2003; 58(2): 324 - 335.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. T. Mitjavila-Garcia, M. Cailleret, I. Godin, M. M. Nogueira, K. Cohen-Solal, V. Schiavon, Y. Lecluse, F. Le Pesteur, A. H. Lagrue, and W. Vainchenker
Expression of CD41 on hematopoietic progenitors derived from embryonic hematopoietic cells
Development, March 6, 2003; 129(8): 2003 - 2013.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. A. Adelman, S. Chattopadhyay, and J. J. Bieker
The BMP/BMPR/Smad pathway directs expression of the erythroid-specific EKLF and GATA1 transcription factors during embryoid body differentiation in serum-free media
Development, March 3, 2003; 129(2): 539 - 549.
[Abstract] [Full Text] [PDF]

Home page
 J. Gerontol. A Biol. Sci. Med. Sci.Home page
Q. He, J. Li, E. Bettiol, and M. E. Jaconi
Embryonic Stem Cells: New Possible Therapy for Degenerative Diseases That Affect Elderly People
J. Gerontol. A Biol. Sci. Med. Sci., March 1, 2003; 58(3): M279 - 287.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
H. K. A. Mikkola, Y. Fujiwara, T. M. Schlaeger, D. Traver, and S. H. Orkin
Expression of CD41 marks the initiation of definitive hematopoiesis in the mouse embryo
Blood, January 15, 2003; 101(2): 508 - 516.
[Abstract] [Full Text] [PDF]

Home page
 Rheumatology (Oxford)Home page
S. Wakitani, K. Takaoka, T. Hattori, N. Miyazawa, T. Iwanaga, S. Takeda, T. K. Watanabe, and A. Tanigami
Embryonic stem cells injected into the mouse knee joint form teratomas and subsequently destroy the joint
Rheumatology, January 1, 2003; 42(1): 162 - 165.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
B. Liu, Y. Sun, F. Jiang, S. Zhang, Y. Wu, Y. Lan, X. Yang, and N. Mao
Disruption of Smad5 gene leads to enhanced proliferation of high-proliferative potential precursors during embryonic hematopoiesis
Blood, January 1, 2003; 101(1): 124 - 133.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
V. I. Rebel, A. L. Kung, E. A. Tanner, H. Yang, R. T. Bronson, and D. M. Livingston
Distinct roles for CREB-binding protein and p300 in hematopoietic stem cell self-renewal
PNAS, November 12, 2002; 99(23): 14789 - 14794.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Jackson, J. W. Baird, N. Cambray, J. D. Ansell, L. M. Forrester, and G. J. Graham
Cloning and Characterization of Ehox, a Novel Homeobox Gene Essential for Embryonic Stem Cell Differentiation
J. Biol. Chem., October 4, 2002; 277(41): 38683 - 38692.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
C. Challier, L. Cocault, R. Berthier, N. Binart, I. Dusanter-Fourt, G. Uzan, and M. Souyri
The cytoplasmic domain of Mpl receptor transduces exclusive signals in embryonic and fetal hematopoietic cells
Blood, August 28, 2002; 100(6): 2063 - 2070.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
J. B. Kearney, C. A. Ambler, K.-A. Monaco, N. Johnson, R. G. Rapoport, and V. L. Bautch
Vascular endothelial growth factor receptor Flt-1 negatively regulates developmental blood vessel formation by modulating endothelial cell division
Blood, April 1, 2002; 99(7): 2397 - 2407.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
S. Viswanathan, T. Benatar, S. Rose-John, D. A. Lauffenburger, and P. W. Zandstra
Ligand/Receptor Signaling Threshold (LIST) Model Accounts for gp130-Mediated Embryonic Stem Cell Self-Renewal Responses to LIF and HIL-6
Stem Cells, March 1, 2002; 20(2): 119 - 138.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
R. C. R. Perlingeiro, M. Kyba, and G. Q. Daley
Clonal analysis of differentiating embryonic stem cells reveals a hematopoietic progenitor with primitive erythroid and adult lymphoid-myeloid potential
Development, November 15, 2001; 128(22): 4597 - 4604.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
F. Li, S. Lu, L. Vida, J. A. Thomson, and G. R. Honig
Bone morphogenetic protein 4 induces efficient hematopoietic differentiation of rhesus monkey embryonic stem cells in vitro
Blood, July 15, 2001; 98(2): 335 - 342.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
I. Hamaguchi, N.-B. Woods, I. Panagopoulos, E. Andersson, H. Mikkola, C. Fahlman, R. Zufferey, L. Carlsson, D. Trono, and S. Karlsson
Lentivirus Vector Gene Expression during ES Cell-Derived Hematopoietic Development In Vitro
J. Virol., November 15, 2000; 74(22): 10778 - 10784.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Schuldiner, O. Yanuka, J. Itskovitz-Eldor, D. A. Melton, and N. Benvenisty
From the Cover: Effects of eight growth factors on the differentiation of cells derived from human embryonic stem cells
PNAS, October 10, 2000; 97(21): 11307 - 11312.
[Abstract] [Full Text] [PDF]

Home page
 NeoReviewsHome page
S. Wang and J. D. Gearhart
Human Pluripotential Stem Cells
NeoReviews, July 1, 2000; 1(7): e132 - 136.
[Full Text]

Home page
 BloodHome page
N. Nakayama, J. Lee, and L. Chiu
Vascular endothelial growth factor synergistically enhances bone morphogenetic protein-4-dependent lymphohematopoietic cell generation from embryonic stem cells in vitro
Blood, April 1, 2000; 95(7): 2275 - 2283.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
M. Allen, L. Svensson, M. Roach, J. Hambor, J. McNeish, and C. A. Gabel
Deficiency of the Stress Kinase p38{alpha} Results in Embryonic Lethality: Characterization of the Kinase Dependence of Stress Responses of Enzyme-deficient Embryonic Stem Cells
J. Exp. Med., March 6, 2000; 191(5): 859 - 870.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
R. Bauchwitz and F. Costantini
Developmentally distinct effects on human {varepsilon}-, {gamma}- and {delta}-globin levels caused by the absence or altered position of the human {beta}-globin gene in YAC transgenic mice
Hum. Mol. Genet., March 1, 2000; 9(4): 561 - 574.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
J Lake, J Rathjen, J Remiszewski, and P. Rathjen
Reversible programming of pluripotent cell differentiation
J. Cell Sci., January 2, 2000; 113(3): 555 - 566.
[Abstract] [PDF]

Home page
 Mol. Cell. Biol.Home page
T. Okuda, K. Takeda, Y. Fujita, M. Nishimura, S. Yagyu, M. Yoshida, S. Akira, J. R. Downing, and T. Abe
Biological Characteristics of the Leukemia-Associated Transcriptional Factor AML1 Disclosed by Hematopoietic Rescue of AML1-Deficient Embryonic Stem Cells by Using a Knock-in Strategy
Mol. Cell. Biol., January 1, 2000; 20(1): 319 - 328.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
J. W. Baird, R. J. B. Nibbs, M. Komai-Koma, J. A. Connolly, K. Ottersbach, I. Clark-Lewis, F. Y. Liew, and G. J. Graham
ESkine, a Novel beta -Chemokine, Is Differentially Spliced to Produce Secretable and Nuclear Targeted Isoforms
J. Biol. Chem., November 19, 1999; 274(47): 33496 - 33503.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Hollnagel, V. Oehlmann, J. Heymer, U. Ruther, and A. Nordheim
Id Genes Are Direct Targets of Bone Morphogenetic Protein Induction in Embryonic Stem Cells
J. Biol. Chem., July 9, 1999; 274(28): 19838 - 19845.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
S. D. Redick and V. L. Bautch
Developmental Platelet Endothelial Cell Adhesion Molecule Expression Suggests Multiple Roles for a Vascular Adhesion Molecule
Am. J. Pathol., April 1, 1999; 154(4): 1137 - 1147.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. Ogawa, M. Kizumoto, S. Nishikawa, T. Fujimoto, H. Kodama, and S.-I. Nishikawa
Expression of alpha 4-Integrin Defines the Earliest Precursor of Hematopoietic Cell Lineage Diverged From Endothelial Cells
Blood, February 15, 1999; 93(4): 1168 - 1177.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
S. BICHET, R. H. WENGER, G. CAMENISCH, A. ROLFS, W. EHLEBEN, T. PORWOL, H. ACKER, J. FANDREY, C. BAUER, and M. GASSMANN
Oxygen tension modulates ß-globin switching in embryoid bodies
FASEB J, February 1, 1999; 13(2): 285 - 295.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. J. Shamblott, J. Axelman, S. Wang, E. M. Bugg, J. W. Littlefield, P. J. Donovan, P. D. Blumenthal, G. R. Huggins, and J. D. Gearhart
Derivation of pluripotent stem cells from cultured human primordial germ cells
PNAS, November 10, 1998; 95(23): 13726 - 13731.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
J. A. Thomson, J. Itskovitz-Eldor, S. S. Shapiro, M. A. Waknitz, J. J. Swiergiel, V. S. Marshall, and J. M. Jones
Embryonic Stem Cell Lines Derived from Human Blastocysts
Science, November 6, 1998; 282(5391): 1145 - 1147.
[Abstract] [Full Text]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
K. J. Moore, R. P. Fabunmi, L. P. Andersson, and M. W. Freeman
In Vitro–Differentiated Embryonic Stem Cell Macrophages : A Model System for Studying Atherosclerosis-Associated Macrophage Functions
Arterioscler. Thromb. Vasc. Biol., October 1, 1998; 18(10): 1647 - 1654.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
R. C. Fisher, M. C. Olson, J. M. R. Pongubala, J. M. Perkel, M. L. Atchison, E. W. Scott, and M. C. Simon
Normal Myeloid Development Requires Both the Glutamine-Rich Transactivation Domain and the PEST Region of Transcription Factor PU.1 but