|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 111, Issue 2 367-378, Copyright © 1991 by Company of Biologists
JOURNAL ARTICLES |
ED Eldon and V Pirrotta
Department of Cell Biology, Baylor College of Medicine, Texas Medical Center, Houston 77030.
The Drosophila gene giant (gt) is a segmentation gene that affects anterior head structures and abdominal segments A5-A7. Immunolocalization of the gt product shows that it is a nuclear protein whose expression is initially activated in an anterior and a posterior domain. Activation of the anterior domain is dependent on the maternal bicoid gradient while activation of the posterior domain requires maternal nanos gene product. Initial expression is not abolished by mutations in any of the zygotic gap genes. By cellular blastoderm, the initial pattern of expression has evolved into one posterior and three anterior stripes of expression. The evolution, position and width of these stripes are dependent on interactions between gt and the other gap genes. In turn, gt activity in these domains affects the expression of the other gap genes. These interactions, typical of the cross-regulation previously observed among gap genes, confirm that gt is a member of the gap gene class whose function is necessary to establish the overall pattern of gap gene expression. After cellular blastoderm, gt protein continues to be expressed in the head region in parts of the maxillary and mandibular segments as well as in the labrum. Expression is never detected in the labial or thoracic segment primordia but persists in certain head structures, including the ring gland, until the end of embryonic development.
This article has been cited by other articles:
|
|
 |
|
  P. S. Kunwar, H. Sano, A. D. Renault, V. Barbosa, N. Fuse, and R. Lehmann Tre1 GPCR initiates germ cell transepithelial migration by regulating Drosophila melanogaster E-cadherin J. Cell Biol., October 6, 2008; 183(1): 157 - 168. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Jaeger, D. Irons, and N. Monk Regulative feedback in pattern formation: towards a general relativistic theory of positional information Development, October 1, 2008; 135(19): 3175 - 3183. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. R. Sanders, M. Patel, and J. W. Mahaffey The Drosophila Gap Gene giant Has an Anterior Segment Identity Function Mediated Through disconnected and teashirt Genetics, May 1, 2008; 179(1): 441 - 453. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. t. Bosch, J. A. Benavides, and T. W. Cline The TAGteam DNA motif controls the timing of Drosophila pre-blastoderm transcription Development, May 15, 2006; 133(10): 1967 - 1977. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Ishihara, K. Fujimoto, and T. Shibata Cross talking of network motifs in gene regulation that generates temporal pulses and spatial stripes Genes Cells, November 1, 2005; 10(11): 1025 - 1038. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Jaeger, M. Blagov, D. Kosman, K. N. Kozlov, Manu, E. Myasnikova, S. Surkova, C. E. Vanario-Alonso, M. Samsonova, D. H. Sharp, et al. Dynamical Analysis of Regulatory Interactions in the Gap Gene System of Drosophila melanogaster Genetics, August 1, 2004; 167(4): 1721 - 1737. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Bucher and M. Klingler Divergent segmentation mechanism in the short germ insect Tribolium revealed by giant expression and function Development, April 15, 2004; 131(8): 1729 - 1740. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. P. Lifanov, V. J. Makeev, A. G. Nazina, and D. A. Papatsenko Homotypic Regulatory Clusters in Drosophila Genome Res., April 1, 2003; 13(4): 579 - 588. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Stein, H. T. Broihier, L. A. Moore, and R. Lehmann Slow as Molasses is required for polarized membrane growth and germ cell migration in Drosophila Development, March 10, 2003; 129(16): 3925 - 3934. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. P. Berman, Y. Nibu, B. D. Pfeiffer, P. Tomancak, S. E. Celniker, M. Levine, G. M. Rubin, and M. B. Eisen Exploiting transcription factor binding site clustering to identify cis-regulatory modules involved in pattern formation in the Drosophila genome PNAS, January 22, 2002; 99(2): 757 - 762. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Fujioka, Y Emi-Sarker, G. Yusibova, T Goto, and J. Jaynes Analysis of an even-skipped rescue transgene reveals both composite and discrete neuronal and early blastoderm enhancers, and multi-stripe positioning by gap gene repressor gradients Development, January 6, 1999; 126(11): 2527 - 2538. [Abstract] [PDF]
|
|
|
|
|
|
G. Hewitt, B. Strunk, C Margulies, T Priputin, X. Wang, R Amey, B. Pabst, D Kosman, J Reinitz, and D. Arnosti Transcriptional repression by the Drosophila giant protein: cis element positioning provides an alternative means of interpreting an effector gradient Development, January 3, 1999; 126(6): 1201 - 1210. [Abstract] [PDF]
|
|
|
|
|
|
X Wu, R Vakani, and S Small Two distinct mechanisms for differential positioning of gene expression borders involving the Drosophila gap protein giant Development, January 10, 1998; 125(19): 3765 - 3774. [Abstract] [PDF]
|
|
|
|
|
|
L. Moore, H. Broihier, M Van Doren, and R Lehmann Gonadal mesoderm and fat body initially follow a common developmental path in Drosophila Development, January 3, 1998; 125(5): 837 - 844. [Abstract] [PDF]
|
|
|
|
|
|
H. Broihier, L. Moore, M Van Doren, S Newman, and R Lehmann zfh-1 is required for germ cell migration and gonadal mesoderm development in Drosophila Development, January 2, 1998; 125(4): 655 - 666. [Abstract] [PDF]
|
|
|
|
|
|
L. Moore, H. Broihier, M Van Doren, L. Lunsford, and R Lehmann Identification of genes controlling germ cell migration and embryonic gonad formation in Drosophila Development, January 2, 1998; 125(4): 667 - 678. [Abstract] [PDF]
|
|
|
|
|
|
A Forbes and R Lehmann Nanos and Pumilio have critical roles in the development and function of Drosophila germline stem cells Development, January 2, 1998; 125(4): 679 - 690. [Abstract] [PDF]
|
|
|
|
|
|
C Wreden, A. Verrotti, J. Schisa, M. Lieberfarb, and S Strickland Nanos and pumilio establish embryonic polarity in Drosophila by promoting posterior deadenylation of hunchback mRNA Development, January 8, 1997; 124(15): 3015 - 3023. [Abstract] [PDF]
|
|
|
|
|
|
D Kosman and S Small Concentration-dependent patterning by an ectopic expression domain of the Drosophila gap gene knirps Development, January 4, 1997; 124(7): 1343 - 1354. [Abstract] [PDF]
|
|
|
|
|
|
R Namba, T. Pazdera, R. Cerrone, and J. Minden Drosophila embryonic pattern repair: how embryos respond to bicoid dosage alteration Development, January 4, 1997; 124(7): 1393 - 1403. [Abstract] [PDF]
|
|
|
|
|
|
C Rongo, E. Gavis, and R Lehmann Localization of oskar RNA regulates oskar translation and requires Oskar protein Development, January 9, 1995; 121(9): 2737 - 2746. [Abstract] [PDF]
|
|
|
|
|
|
F Casares and E Sanchez-Herrero Regulation of the infraabdominal regions of the bithorax complex of Drosophila by gap genes Development, January 6, 1995; 121(6): 1855 - 1866. [Abstract] [PDF]
|
|
|
|
|
|
C Schulz and D Tautz Zygotic caudal regulation by hunchback and its role in abdominal segment formation of the Drosophila embryo Development, January 4, 1995; 121(4): 1023 - 1028. [Abstract] [PDF]
|
|
|
|
|
|
U Grossniklaus, K. Cadigan, and W. Gehring Three maternal coordinate systems cooperate in the patterning of the Drosophila head Development, January 11, 1994; 120(11): 3155 - 3171. [Abstract] [PDF]
|
|
|
|
|
|
C Schulz and D Tautz Autonomous concentration-dependent activation and repression of Kruppel by hunchback in the Drosophila embryo Development, January 10, 1994; 120(10): 3043 - 3049. [Abstract] [PDF]
|
|
|
|
|
|
C Tsai and J. Gergen Gap gene properties of the pair-rule gene runt during Drosophila segmentation Development, January 6, 1994; 120(6): 1671 - 1683. [Abstract] [PDF]
|
|
|
|
|
|
J. Langeland and S. Carroll Conservation of regulatory elements controlling hairy pair-rule stripe formation Development, January 2, 1993; 117(2): 585 - 596. [Abstract] [PDF]
|
|
|
|
|
|
T Gutjahr, E Frei, and M Noll Complex regulation of early paired expression: initial activation by gap genes and pattern modulation by pair-rule genes Development, January 2, 1993; 117(2): 609 - 623. [Abstract] [PDF]
|
|
|
|
 |
|
 U Grossniklaus, R K Pearson, and W J Gehring The Drosophila sloppy paired locus encodes two proteins involved in segmentation that show homology to mammalian transcription factors. Genes & Dev., June 1, 1992; 6(6): 1030 - 1051. [Abstract] [PDF]
|
|
|
|
 |
|
 M Hoch, N Gerwin, H Taubert, and H Jackle Competition for overlapping sites in the regulatory region of the Drosophila gene Kruppel Science, April 3, 1992; 256(5053): 94 - 97. [Abstract] [PDF]
|
|
|
|
|
|
M. Pankratz, M Busch, M Hoch, E Seifert, and H Jackle Spatial control of the gap gene knirps in the Drosophila embryo by posterior morphogen system Science, February 21, 1992; 255(5047): 986 - 989. [Abstract] [PDF]
|
|
|
|
|
|
J B Duffy and J P Gergen The Drosophila segmentation gene runt acts as a position-specific numerator element necessary for the uniform expression of the sex-determining gene Sex-lethal. Genes & Dev., December 1, 1991; 5(12a): 2176 - 2187. [Abstract] [PDF]
|
|
