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Development, Vol 111, Issue 4 1057-1060, Copyright © 1991 by Company of Biologists

JOURNAL ARTICLES

IGF-2 receptors are first expressed at the 2-cell stage of mouse development

MB Harvey and PL Kaye
Department of Physiology and Pharmacology, University of Queensland, Australia.

A specific IGF-2 receptor antiserum was used to reveal the presence of IGF-2 receptors during preimplantation development of mice. Receptors were present on 2-, 4- and 8-cell embryos, morulae, blastocysts, and on ICMs isolated prior to staining. There was no evidence for receptors on fertilized eggs. These observations confirm reports of the expression of IGF-2 receptor mRNA as early as the 2-cell stage and refine similar observations in blastocysts to confirm expression in both the TE and ICM. A potential auto/paracrine loop is thus one of the first products of activation of the embryonic genome and is expressed constitutively through preimplantation development.


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© The Company of Biologists Ltd 1991