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A new monoclonal antibody, MEBL-1, which specifically melanocytes and their precursors, was used to examine differentiation of neural crest cells into melanocytes positive precursors of melanocytes in the trunk were mesenchyme located above the neural tube at the level stage 19, when active migration of neural crest cells route was almost complete. DiO-labelled neural crest to emigrate from the neural tube at stages 17-18 and the dorsolateral route, were found to become MEBL-1- indicates that MEBL-1 antigens are expressed by neural immediately following their emigration and neural melanogenic. Expression of the MEBL-1 antigens was in, and finally the loss of, HNK-1 antigen expression. level, MEBL-1-positive precursors of melanocytes were mesenchyme located above the dorsal side of the tube at stage 16. At the vagal level, the precursors in mesenchyme located above the dorsal side of the neural tube at stage 18. MEBL-1 reacted with the cell premelanosome-like granules in addition to the nuclear endoplasmic reticulum and Golgi apparatus of the The antigens recognized by MEBL-1 were proteins with masses of 135x103 and 115x103. We suggest that MEBL-1 earliest marker for melanogenic neural crest cells.
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A. Santiago and C. A. Erickson Ephrin-B ligands play a dual role in the control of neural crest cell migration Development, August 1, 2002; 129(15): 3621 - 3632. [Abstract] [Full Text] [PDF]
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R Kos, M. Reedy, R. Johnson, and C. Erickson The winged-helix transcription factor FoxD3 is important for establishing the neural crest lineage and repressing melanogenesis in avian embryos Development, January 4, 2001; 128(8): 1467 - 1479. [Abstract] [PDF]
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Y Wakamatsu, M Mochii, K. Vogel, and J. Weston Avian neural crest-derived neurogenic precursors undergo apoptosis on the lateral migration pathway Development, January 11, 1998; 125(21): 4205 - 4213. [Abstract] [PDF]
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P. Henion and J. Weston Timing and pattern of cell fate restrictions in the neural crest lineage Development, January 11, 1997; 124(21): 4351 - 4359. [Abstract] [PDF]
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C. Baker, M Bronner-Fraser, N. Le Douarin, and M. Teillet Early- and late-migrating cranial neural crest cell populations have equivalent developmental potential in vivo Development, January 8, 1997; 124(16): 3077 - 3087. [Abstract] [PDF]
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C. Erickson and T. Goins Avian neural crest cells can migrate in the dorsolateral path only if they are specified as melanocytes Development, January 3, 1995; 121(3): 915 - 924. [Abstract] [PDF]
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