spacer gif spacer gif spacer gif spacer gif ARCHIVE ANNOUNCEMENT! spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jerka-Dziadosz, M.
Right arrow Articles by Beisson, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jerka-Dziadosz, M.
Right arrow Articles by Beisson, J.

Development, Vol 115, Issue 1 319-335, Copyright © 1992 by Company of Biologists

JOURNAL ARTICLES

Development of surface pattern during division in Paramecium. II. Defective spatial control in the mutant kin241

M Jerka-Dziadosz, N Garreau de Loubresse and J Beisson
Centre de Genetique Moleculaire, Gif-sur-Yvette, France.

kin241 is a monogenic nuclear recessive mutation producing highly pleiotropic effects on cell size and shape, generation time, thermosensitivity, nuclear reorganization and cortical organization. We have analyzed the nature of the cortical disorders and their development during division, using various specific antibodies labelling either one of the cortical cytoskeleton components, as was previously done for analysis of cortical pattern formation in the wild type. Several abnormalities in basal body properties were consistently observed, although with a variable frequency: extra microtubules in either the triplets or in the lumen; nucleation of a second kinetodesmal fiber; abnormal orientation of the newly formed basal body with respect to the mother one. The latter effect seems to account for the major observed cortical disorders (reversal, intercalation of supplementary ciliary rows). The second major effect of the mutation concerns the spatiotemporal map of cortical reorganization during division. Excess basal body proliferation occurs and is correlated with modified boundaries of some of the cortical domains identified in the wild type on the basis of their basal body duplication pattern. This is the first mutant described in a ciliate in which both the structure and duplication of basal bodies and the body plan are affected. The data support the conclusion that the mutation does not alter the nature of the morphogenetic signal(s) which pervade the dividing cell, nor the competence of cytoskeletal structures to respond to signalling, but affects the local interpretation of the signals.


This article has been cited by other articles:


Home page
 Eukaryot CellHome page
J. Frankel
What Do Genic Mutations Tell Us about the Structural Patterning of a Complex Single-Celled Organism?
Eukaryot. Cell, October 1, 2008; 7(10): 1617 - 1639.
[Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
U Nagel and H Machemer
Physical and physiological components of the graviresponses of wild-type and mutant Paramecium Tetraurelia
J. Exp. Biol., January 3, 2000; 203(6): 1059 - 1070.
[Abstract] [PDF]

Home page
 DevelopmentHome page
M Jerka-Dziadosz, F Ruiz, and F Beisson
Uncoupling of basal body duplication and cell division in crochu, a mutant of Paramecium hypersensitive to nocodazole
Development, January 4, 1998; 125(7): 1305 - 1314.
[Abstract] [PDF]

Home page
 J. Cell Sci.Home page
M Prajer, A Fleury, and M Laurent
Dynamics of calcium regulation in Paramecium and possible morphogenetic implication
J. Cell Sci., January 3, 1997; 110(5): 529 - 535.
[Abstract] [PDF]


© The Company of Biologists Ltd 1992