|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 115, Issue 4 989-997, Copyright © 1992 by Company of Biologists
JOURNAL ARTICLES |
B Dalby and DM Glover
Department of Biochemistry, The University, Dundee, Scotland.
We have characterised forms of the Drosophila cyclin B transcript that differ as a result of a splicing event which removes a nucleotide segment from the 3' untranslated region. In oogenesis, both cyclin A RNA and a shorter form of the cyclin B transcript are seen in the cells of the germarium that are undergoing mitosis. The shorter cyclin B transcript alone is then detectable in the presumptive oocyte until stages 7-8 of oogenesis. Both cyclin A RNA and a longer form of the cyclin B RNA are then synthesised in the nurse cells during stages 9-11, to be deposited in the oocyte during stages 11-12. These transcripts become evenly distributed throughout the oocyte cytoplasm but, in addition, those of cyclin B become concentrated at the posterior pole. Examination of the distributions of RNAs transcribed from chimeric cyclin genes indicates that sequences in the 3' untranslated region of the larger cyclin B RNA are required both for it to become concentrated at the posterior pole and to direct those transcripts in the body of the syncytial embryo to their peri-nuclear localisation. These sequences are disrupted by the splicing event which generates smaller cyclin B transcripts.
This article has been cited by other articles:
|
|
 |
|
  A. Jambhekar and J. L. DeRisi Cis-acting determinants of asymmetric, cytoplasmic RNA transport RNA, May 1, 2007; 13(5): 625 - 642. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kloc and L. D. Etkin RNA localization mechanisms in oocytes J. Cell Sci., January 15, 2005; 118(2): 269 - 282. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. S. Chandler, M. E. McGuffin, and W. Mattox Functionally antagonistic sequences are required for normal autoregulation of Drosophila tra-2 pre-mRNA splicing Nucleic Acids Res., July 15, 2001; 29(14): 3012 - 3019. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. P. Schonbaum, J. J. Perrino, and A. P. Mahowald Regulation of the Vitellogenin Receptor during Drosophila melanogaster Oogenesis Mol. Biol. Cell, February 1, 2000; 11(2): 511 - 521. [Abstract] [Full Text]
|
|
|
|
|
|
B Grallert, S. Kearsey, M Lenhard, C. Carlson, P Nurse, E Boye, and K Labib A fission yeast general translation factor reveals links between protein synthesis and cell cycle controls J. Cell Sci., January 4, 2000; 113(8): 1447 - 1458. [Abstract] [PDF]
|
|
|
|
 |
|
 P. LASKO RNA sorting in Drosophila oocytes and embryos FASEB J, March 1, 1999; 13(3): 421 - 433. [Abstract] [Full Text]
|
|
|
|
 |
|
 H. W. Jacobs, J. A. Knoblich, and C. F. Lehner Drosophila Cyclin B3 is required for female fertility and is dispensable for mitosis like Cyclin B Genes & Dev., December 1, 1998; 12(23): 3741 - 3751. [Abstract] [Full Text]
|
|
|
|
 |
|
 H White-Cooper, M. Schafer, L. Alphey, and M. Fuller Transcriptional and post-transcriptional control mechanisms coordinate the onset of spermatid differentiation with meiosis I in Drosophila Development, January 1, 1998; 125(1): 125 - 134. [Abstract] [PDF]
|
|
|
|
|
|
B. Reed and T. Orr-Weaver The Drosophila gene morula inhibits mitotic functions in the endo cell cycle and the mitotic cell cycle Development, January 9, 1997; 124(18): 3543 - 3553. [Abstract] [PDF]
|
|
|
|
|
|
M. Kreutzer, J. Richards, M. De Silva-Udawatta, J. Temenak, J. Knoblich, C. Lehner, and K. Bennett Caenorhabditis elegans cyclin A- and B-type genes: a cyclin A multigene family, an ancestral cyclin B3 and differential germline expression J. Cell Sci., January 6, 1995; 108(6): 2415 - 2424. [Abstract] [PDF]
|
|
|
|
|
|
L B Christerson and D M McKearin orb is required for anteroposterior and dorsoventral patterning during Drosophila oogenesis. Genes & Dev., March 1, 1994; 8(5): 614 - 628. [Abstract] [PDF]
|
|
|
|
|
|
L Liang, W Diehl-Jones, and P Lasko Localization of vasa protein to the Drosophila pole plasm is independent of its RNA-binding and helicase activities Development, January 5, 1994; 120(5): 1201 - 1211. [Abstract] [PDF]
|
|
|
|
|
|
B Ran, R Bopp, and B Suter Null alleles reveal novel requirements for Bic-D during Drosophila oogenesis and zygotic development Development, January 5, 1994; 120(5): 1233 - 1242. [Abstract] [PDF]
|
|
|
|
|
|
H. Richardson, L. O'Keefe, S. Reed, and R Saint A Drosophila G1-specific cyclin E homolog exhibits different modes of expression during embryogenesis Development, January 11, 1993; 119(3): 673 - 690. [Abstract] [PDF]
|
|
|
|
|
|
J Kim-Ha, P. Webster, J. Smith, and P. Macdonald Multiple RNA regulatory elements mediate distinct steps in localization of oskar mRNA Development, January 9, 1993; 119(1): 169 - 178. [Abstract] [PDF]
|
|
|
|
|
|
W. Theurkauf, B. Alberts, Y. Jan, and T. Jongens A central role for microtubules in the differentiation of Drosophila oocytes Development, January 8, 1993; 118(4): 1169 - 1180. [Abstract] [PDF]
|
|
