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Development, Vol 116, Issue 1 1-12, Copyright © 1992 by Company of Biologists
JOURNAL ARTICLES |
D. Kimelman, J. L. Christian and R. T. Moon
The first inductive event in Xenopus development establishes the mesoderm at the equator of the developing embryo. As part of this process, the dorsal-ventral and anterior-posterior axes of the embryo are initially established. A number of signalling molecules which may play a role in mesodermal induction and patterning have been identified in the last several years, including members of the FGF, TGF-beta and Wnt gene families. A variety of experiments, using either purified factors or injection of RNA encoding these factors, have added to the wealth of classical embryogical experimental data collected over the last century. We have synthesized some recent results with the classical data to provide a framework for examining the process of mesoderm induction, and to formulate putative roles for some of the different factors. We incorporate these ideas into a working model of mesoderm induction that provides a basis for future experimental directions. Finally, we suggest that mesoderm induction may not be a discrete set of well separated events, but instead may be a process involving partially overlapping signals that produce the same pattern.
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M. Ku and D. A. Melton Xwnt-11: a maternally expressed Xenopus wnt gene Development, December 1, 1993; 119(4): 1161 - 1173. [Abstract] [PDF]
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G von Dassow, J E Schmidt, and D Kimelman Induction of the Xenopus organizer: expression and regulation of Xnot, a novel FGF and activin-regulated homeo box gene. Genes & Dev., March 1, 1993; 7(3): 355 - 366. [Abstract] [PDF]
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R. Moon, R. Campbell, J. Christian, L. McGrew, J Shih, and S Fraser Xwnt-5A: a maternal Wnt that affects morphogenetic movements after overexpression in embryos of Xenopus laevis Development, January 9, 1993; 119(1): 97 - 111. [Abstract] [PDF]
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E. Davidson Later embryogenesis: regulatory circuitry in morphogenetic fields Development, January 7, 1993; 118(3): 665 - 690. [Abstract] [PDF]
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C Kelley, H Blumberg, L. Zon, and T Evans GATA-4 is a novel transcription factor expressed in endocardium of the developing heart Development, January 7, 1993; 118(3): 817 - 827. [Abstract] [PDF]
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E Amaya, P. Stein, T. Musci, and M. Kirschner FGF signalling in the early specification of mesoderm in Xenopus Development, January 6, 1993; 118(2): 477 - 487. [Abstract] [PDF]
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H Steinbeisser, E. De Robertis, M Ku, D. Kessler, and D. Melton Xenopus axis formation: induction of goosecoid by injected Xwnt-8 and activin mRNAs Development, January 6, 1993; 118(2): 499 - 507. [Abstract] [PDF]
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H Sasaki and B. Hogan Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo Development, January 5, 1993; 118(1): 47 - 59. [Abstract] [PDF]
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