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Development, Vol 116, Issue 2 457-466, Copyright © 1992 by Company of Biologists
JOURNAL ARTICLES |
DA Waring, L Wrischnik and C Kenyon
Department of Biochemistry and Biophysics, University of California, San Francisco 94143-0554.
In C. elegans, a simple pattern develops within a row of epidermal precursor cells, V1-V6. One cell, V5, gives rise to a neuroblast called the postdeirid neuroblast, while the other V cells produce epidermal cells instead. Here we describe experiments suggesting that in order for V5 to produce the postdeirid it must be in close or direct contact with neighboring V cells. Signaling between V cells is required for the formation of the neuroblast; however, which of the V cells can make a postdeirid is not determined by these signals but rather by the action of the homeotic lin-22 and pal-1 genes. These genes prevent V cells in specific body regions from responding to intercellular signals and producing postdeirids. This is a clear example of cell signals playing a permissive rather than an instructive role in neuroblast induction.
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S Alper and C Kenyon REF-1, a protein with two bHLH domains, alters the pattern of cell fusion in C. elegans by regulating Hox protein activity Development, January 5, 2001; 128(10): 1793 - 1804. [Abstract] [PDF]
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C. Hunter, J. Harris, J. Maloof, and C Kenyon Hox gene expression in a single Caenorhabditis elegans cell is regulated by a caudal homolog and intercellular signals that inhibit wnt signaling Development, January 2, 1999; 126(4): 805 - 814. [Abstract] [PDF]
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L. Wrischnik and C. Kenyon The role of lin-22, a hairy/enhancer of split homolog, in patterning the peripheral nervous system of C. elegans Development, January 8, 1997; 124(15): 2875 - 2888. [Abstract] [PDF]
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S. Salser and C Kenyon A C. elegans Hox gene switches on, off, on and off again to regulate proliferation, differentiation and morphogenesis Development, January 5, 1996; 122(5): 1651 - 1661. [Abstract] [PDF]
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K. Chow, D. Hall, and S. Emmons The mab-21 gene of Caenorhabditis elegans encodes a novel protein required for choice of alternate cell fates Development, January 11, 1995; 121(11): 3615 - 3626. [Abstract] [PDF]
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K. L. Chow and S. W. Emmons HOM-C/Hox genes and four interacting loci determine the morphogenetic properties of single cells in the nematode male tail Development, September 1, 1994; 120(9): 2579 - 2592. [Abstract] [PDF]
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J Austin and C Kenyon Cell contact regulates neuroblast formation in the Caenorhabditis elegans lateral epidermis Development, January 2, 1994; 120(2): 313 - 323. [Abstract] [PDF]
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