|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 116, Issue 3 799-804, Copyright © 1992 by Company of Biologists
JOURNAL ARTICLES |
T Schimmang, M Lemaistre, A Vortkamp and U Ruther
European Molecular Biology Laboratory, Heidelberg, Germany.
Genetic analysis and homology between the phenotypic alterations of the human Greig Cephalopolysyndactyly Syndrome (GCPS) and the mouse mutant extra-toes (Xt) have suggested a dominant mutation in the same gene of both species. Recently, the GLI3 gene, a member of the Kruppel-related zinc finger genes, has been proposed as a candidate gene for GCPS. We examined the expression of the mouse Gli3 gene in both Xt mutant animals and during normal mouse development. Northern and RNAase protection analysis of embryos revealed that Gli3 expression was reduced about 50% in heterozygous Xt/+ mice and completely absent in homozygous Xt/Xt mice. In addition, in situ analysis of wild-type mice documented Gli3 expression in the developing limb and brain, structures affected in Xt mutant mice. This pattern suggests an important function of the Gli3 gene during morphogenesis.
This article has been cited by other articles:
|
|
 |
|
  M. Varjosalo and J. Taipale Hedgehog: functions and mechanisms Genes & Dev., September 15, 2008; 22(18): 2454 - 2472. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. C. Russell, R. G. Cowan, R. M. Harman, A. L. Walker, and S. M. Quirk The Hedgehog Signaling Pathway in the Mouse Ovary Biol Reprod, August 1, 2007; 77(2): 226 - 236. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Kawasaki, K. Ito, and T. Hirata Netrin 1 regulates ventral tangential migration of guidepost neurons in the lateral olfactory tract Development, March 1, 2006; 133(5): 845 - 853. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Hu, R. Mo, S. Bhella, C. W. Wilson, P.-T. Chuang, C.-c. Hui, and N. D. Rosenblum GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis Development, February 1, 2006; 133(3): 569 - 578. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Koziel, M. Wuelling, S. Schneider, and A. Vortkamp Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation Development, December 1, 2005; 132(23): 5249 - 5260. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. L. Hager-Theodorides, J. T. Dessens, S. V. Outram, and T. Crompton The transcription factor Gli3 regulates differentiation of fetal CD4-CD8- double-negative thymocytes Blood, August 15, 2005; 106(4): 1296 - 1304. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Nguyen, A. L. Chokas, B. Stecca, and A. R. i Altaba Cooperative requirement of the Gli proteins in neurogenesis Development, July 15, 2005; 132(14): 3267 - 3279. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kuijper, A. Beverdam, C. Kroon, A. Brouwer, S. Candille, G. Barsh, and F. Meijlink Genetics of shoulder girdle formation: roles of Tbx15 and aristaless-like genes Development, April 1, 2005; 132(7): 1601 - 1610. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Ganss and A. Jheon ZINC FINGER TRANSCRIPTION FACTORS IN SKELETAL DEVELOPMENT Critical Reviews in Oral Biology & Medicine, September 1, 2004; 15(5): 282 - 297. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. te Welscher, M. Fernandez-Teran, M. A. Ros, and R. Zeller Mutual genetic antagonism involving GLI3 and dHAND prepatterns the vertebrate limb bud mesenchyme prior to SHH signaling Genes & Dev., February 15, 2002; 16(4): 421 - 426. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Rallu, R. Machold, N. Gaiano, J. G. Corbin, A. P. McMahon, and G. Fishell Dorsoventral patterning is established in the telencephalon of mutants lacking both Gli3 and Hedgehog signaling Development, January 11, 2002; 129(21): 4963 - 4974. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. G. McFadden, J. McAnally, J. A. Richardson, J. Charite, and E. N. Olson Misexpression of dHAND induces ectopic digits in the developing limb bud in the absence of direct DNA binding Development, January 7, 2002; 129(13): 3077 - 3088. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Tomioka, N. Osumi, Y. Sato, T. Inoue, S. Nakamura, H. Fujisawa, and T. Hirata Neocortical Origin and Tangential Migration of Guidepost Neurons in the Lateral Olfactory Tract J. Neurosci., August 1, 2000; 20(15): 5802 - 5812. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Fernandez-Teran, M. E. Piedra, I. S. Kathiriya, D. Srivastava, J. C. Rodriguez-Rey, and M. A. Ros Role of dHAND in the anterior-posterior polarization of the limb bud: implications for the Sonic hedgehog pathway Development, May 15, 2000; 127(10): 2133 - 2142. [Abstract] [PDF]
|
|
|
|
|
|
H. Park, C Bai, K. Platt, M. Matise, A Beeghly, C. Hui, M Nakashima, and A. Joyner Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation Development, January 4, 2000; 127(8): 1593 - 1605. [Abstract] [PDF]
|
|
|
|
 |
|
 E. A. Grove and S. Tole Patterning Events and Specification Signals in the Developing Hippocampus Cereb Cortex, September 1, 1999; 9(6): 551 - 561. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Iwamoto, M. Enomoto-Iwamoto, and K. Kurisu Actions of Hedgehog Proteins on Skeletal Cells Critical Reviews in Oral Biology & Medicine, July 1, 1999; 10(4): 477 - 486. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T Theil, G Alvarez-Bolado, A Walter, and U Ruther Gli3 is required for Emx gene expression during dorsal telencephalon development Development, January 8, 1999; 126(16): 3561 - 3571. [Abstract] [PDF]
|
|
|
|
|
|
A Zuniga and R Zeller Gli3 (Xt) and formin (ld) participate in the positioning of the polarising region and control of posterior limb-bud identity Development, January 1, 1999; 126(1): 13 - 21. [Abstract] [PDF]
|
|
|
|
|
|
S Qu, S. Tucker, Q Zhao, B deCrombrugghe, and R Wisdom Physical and genetic interactions between Alx4 and Cart1 Development, January 1, 1999; 126(2): 359 - 369. [Abstract] [PDF]
|
|
|
|
|
|
Q Ding, J Motoyama, S Gasca, R Mo, H Sasaki, J Rossant, and C. Hui Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice Development, January 7, 1998; 125(14): 2533 - 2543. [Abstract] [PDF]
|
|
|
|
|
|
S Qu, S. Tucker, J. Ehrlich, J. Levorse, L. Flaherty, R Wisdom, and T. Vogt Mutations in mouse Aristaless-like4 cause Strong's luxoid polydactyly Development, January 7, 1998; 125(14): 2711 - 2721. [Abstract] [PDF]
|
|
|
|
|
|
E. Grove, S Tole, J Limon, L Yip, and C. Ragsdale The hem of the embryonic cerebral cortex is defined by the expression of multiple Wnt genes and is compromised in Gli3-deficient mice Development, January 6, 1998; 125(12): 2315 - 2325. [Abstract] [PDF]
|
|
|
|
|
|
V Knezevic, R De Santo, K Schughart, U Huffstadt, C Chiang, K. Mahon, and S Mackem Hoxd-12 differentially affects preaxial and postaxial chondrogenic branches in the limb and regulates Sonic hedgehog in a positive feedback loop Development, January 11, 1997; 124(22): 4523 - 4536. [Abstract] [PDF]
|
|
|
|
|
|
S Qu, K. Niswender, Q Ji, R van der Meer, D Keeney, M. Magnuson, and R Wisdom Polydactyly and ectopic ZPA formation in Alx-4 mutant mice Development, January 10, 1997; 124(20): 3999 - 4008. [Abstract] [PDF]
|
|
|
|
|
|
C. Peichel, B Prabhakaran, and T. Vogt The mouse Ulnaless mutation deregulates posterior HoxD gene expression and alters appendicular patterning Development, January 9, 1997; 124(18): 3481 - 3492. [Abstract] [PDF]
|
|
|
|
|
|
J Lee, K. Platt, P Censullo, and A Ruiz i Altaba Gli1 is a target of Sonic hedgehog that induces ventral neural tube development Development, January 7, 1997; 124(13): 2537 - 2552. [Abstract] [PDF]
|
|
|
|
|
|
M Yoshida, Y Suda, I Matsuo, N Miyamoto, N Takeda, S Kuratani, and S Aizawa Emx1 and Emx2 functions in development of dorsal telencephalon Development, January 1, 1997; 124(1): 101 - 111. [Abstract] [PDF]
|
|
|
|
|
|
R Mo, A. Freer, D. Zinyk, M. Crackower, J Michaud, H. Heng, K. Chik, X. Shi, L. Tsui, S. Cheng, et al. Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development Development, January 1, 1997; 124(1): 113 - 123. [Abstract] [PDF]
|
|
|
|
|
|
H Masuya, T Sagai, S Wakana, K Moriwaki, and T Shiroishi A duplicated zone of polarizing activity in polydactylous mouse mutants. Genes & Dev., July 1, 1995; 9(13): 1645 - 1653. [Abstract] [PDF]
|
|
|
|
|
|
F. van der Hoeven, T. Schimmang, A. Volkmann, M. G. Mattei, B. Kyewski, and U. Ruther Programmed cell death is affected in the novel mouse mutant Fused toes (Ft) Development, September 1, 1994; 120(9): 2601 - 2607. [Abstract] [PDF]
|
|
|
|
|
|
T Gunther, M Struwe, A Aguzzi, and K Schughart Open brain, a new mouse mutant with severe neural tube defects, shows altered gene expression patterns in the developing spinal cord Development, January 11, 1994; 120(11): 3119 - 3130. [Abstract] [PDF]
|
|
|
|
|
|
D. Chang, A Lopez, D. von Kessler, C Chiang, B. Simandl, R Zhao, M. Seldin, J. Fallon, and P. Beachy Products, genetic linkage and limb patterning activity of a murine hedgehog gene Development, January 11, 1994; 120(11): 3339 - 3353. [Abstract] [PDF]
|
|
|
|
 |
|
 N. Copeland, N. Jenkins, D. Gilbert, J. Eppig, L. Maltais, J. Miller, W. Dietrich, A Weaver, S. Lincoln, R. Steen, et al. A genetic linkage map of the mouse: current applications and future prospects Science, October 1, 1993; 262(5130): 57 - 66. [Abstract] [PDF]
|
|
