|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 117, Issue 1 97-104, Copyright © 1993 by Company of Biologists
JOURNAL ARTICLES |
SG Kuhar, L Feng, S Vidan, ME Ross, ME Hatten and N Heintz
Department of Molecular Biology, Howard Hughes Medical Institute, Rockefeller University, New York, NY 10021-6399.
Among CNS neuronal populations, the cerebellar granule cell provides a simple model for analysing the molecular regulation of CNS neurogenesis. In this study, polyclonal antisera raised against immature granule cell precursors, purified from early postnatal mouse cerebellum, were used to isolate 39 unique cDNA clones from a lambda gt11 cDNA expression library made from the same cell population. Northern blot analysis revealed developmental stage and tissue-specific expression of 28 of the clones. In situ localization of mRNAs encoded by these novel cDNAs, as well as those encoding the axonal glycoprotein TAG-1 and the alpha 6 subunit of the GABAA receptor, reveal four distinct stages in cerebellar granule cell differentiation. The developmentally transient and spatially restricted expression of clones GC9 and GC44 identify a previously unrecognized step in cerebellar histogenesis.
This article has been cited by other articles:
|
|
 |
|
  T. Koontz, M. Bralic, J. Tomac, E. Pernjak-Pugel, G. Bantug, S. Jonjic, and W. J. Britt Altered development of the brain after focal herpesvirus infection of the central nervous system J. Exp. Med., February 18, 2008; 205(2): 423 - 435. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Chen, G. Liao, R. R. Waclaw, K. A. Burns, D. Linquist, K. Campbell, Y. Zheng, and C.-Y. Kuan Rac1 Controls the Formation of Midline Commissures and the Competency of Tangential Migration in Ventral Telencephalic Neurons J. Neurosci., April 4, 2007; 27(14): 3884 - 3893. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Klein, S. J. B. Butt, R. P. Machold, J. E. Johnson, and G. Fishell Cerebellum- and forebrain-derived stem cells possess intrinsic regional character Development, October 15, 2005; 132(20): 4497 - 4508. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Blaess, D. Graus-Porta, R. Belvindrah, R. Radakovits, S. Pons, A. Littlewood-Evans, M. Senften, H. Guo, Y. Li, J. H. Miner, et al. {beta}1-Integrins Are Critical for Cerebellar Granule Cell Precursor Proliferation J. Neurosci., March 31, 2004; 24(13): 3402 - 3412. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Wechsler-Reya Analysis of Gene Expression in the Normal and Malignant Cerebellum Recent Prog. Horm. Res., January 1, 2003; 58(1): 227 - 248. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Bizzoca, D. Virgintino, L. Lorusso, M. Buttiglione, L. Yoshida, A. Polizzi, M. Tattoli, R. Cagiano, F. Rossi, S. Kozlov, et al. Transgenic mice expressing F3/contactin from the TAG-1 promoter exhibit developmentally regulated changes in the differentiation of cerebellar neurons Development, January 1, 2003; 130(1): 29 - 43. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Yacubova and H. Komuro Intrinsic Program for Migration of Cerebellar Granule Cells In Vitro J. Neurosci., July 15, 2002; 22(14): 5966 - 5981. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. G. Patel, C. Liu, P. L. Cameron, and R. S. Cameron Myr 8, A Novel Unconventional Myosin Expressed during Brain Development Associates with the Protein Phosphatase Catalytic Subunits 1{alpha} and 1{gamma}1 J. Neurosci., October 15, 2001; 21(20): 7954 - 7968. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-i. Sakakibara, Y. Nakamura, H. Satoh, and H. Okano RNA-Binding Protein Musashi2: Developmentally Regulated Expression in Neural Precursor Cells and Subpopulations of Neurons in Mammalian CNS J. Neurosci., October 15, 2001; 21(20): 8091 - 8107. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Sakurai, M. Lustig, J. Babiarz, A. J.W. Furley, S. Tait, P. J. Brophy, S. A. Brown, L. Y. Brown, C. A. Mason, and M. Grumet Overlapping functions of the cell adhesion molecules Nr-CAM and L1 in cerebellar granule cell development J. Cell Biol., September 17, 2001; 154(6): 1259 - 1274. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Komuro, E. Yacubova, E. Yacubova, and P. Rakic Mode and Tempo of Tangential Cell Migration in the Cerebellar External Granular Layer J. Neurosci., January 15, 2001; 21(2): 527 - 540. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. Bhatt, T. Tomoda, Y. Fang, and M. E. Hatten Discoidin domain receptor 1 functions in axon extension of cerebellar granule neurons Genes & Dev., September 1, 2000; 14(17): 2216 - 2228. [Abstract] [Full Text]
|
|
|
|
|
|
N Dahmane and A Ruiz-i-Altaba Sonic hedgehog regulates the growth and patterning of the cerebellum Development, January 6, 1999; 126(14): 3089 - 3100. [Abstract] [PDF]
|
|
|
|
|
|
J. R. Mellor, D. Merlo, A. Jones, W. Wisden, and A. D. Randall Mouse Cerebellar Granule Cell Differentiation: Electrical Activity Regulates the GABAA Receptor alpha 6 Subunit Gene J. Neurosci., April 15, 1998; 18(8): 2822 - 2833. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Komuro and P. Rakic Distinct Modes of Neuronal Migration in Different Domains of Developing Cerebellar Cortex J. Neurosci., February 15, 1998; 18(4): 1478 - 1490. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-i. Sakakibara and H. Okano Expression of Neural RNA-Binding Proteins in the Postnatal CNS: Implications of Their Roles in Neuronal and Glial Cell Development J. Neurosci., November 1, 1997; 17(21): 8300 - 8312. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Bahn, A. Jones, and W. Wisden Directing gene expression to cerebellar granule cells using gamma -aminobutyric acid type A receptor alpha 6 subunit transgenes PNAS, August 19, 1997; 94(17): 9417 - 9421. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Guerrini, A. Molteni, T. Wirth, B. Kistler, and F. Blasi Glutamate-Dependent Activation of NF-kappa B During Mouse Cerebellum Development J. Neurosci., August 15, 1997; 17(16): 6057 - 6063. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Z. Xu, R. Sanchez, A. Sali, and N. Heintz Ligand Specificity of Brain Lipid-binding Protein J. Biol. Chem., October 4, 1996; 271(40): 24711 - 24719. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Schmidt-Ullrich, S. Memet, A. Lilienbaum, J. Feuillard, M. Raphael, and A. Israel NF-kappaB activity in transgenic mice: developmental regulation and tissue specificity Development, July 1, 1996; 122(7): 2117 - 2128. [Abstract] [PDF]
|
|
|
|
|
|
X. Yang, R Zhong, and N Heintz Granule cell specification in the developing mouse brain as defined by expression of the zinc finger transcription factor RU49 Development, January 2, 1996; 122(2): 555 - 566. [Abstract] [PDF]
|
|
|
|
|
|
A. Kurtz, A. Zimmer, F. Schnutgen, G. Bruning, F. Spener, and T. Muller The expression pattern of a novel gene encoding brain-fatty acid binding protein correlates with neuronal and glial cell development Development, September 1, 1994; 120(9): 2637 - 2649. [Abstract] [PDF]
|
|
|
|
|
|
D. Merry, D. Veis, W. Hickey, and S. Korsmeyer bcl-2 protein expression is widespread in the developing nervous system and retained in the adult PNS Development, January 2, 1994; 120(2): 301 - 311. [Abstract] [PDF]
|
|
|
|
|
|
K. Kasahara, K. Watanabe, K. Takeuchi, H. Kaneko, A. Oohira, T. Yamamoto, and Y. Sanai Involvement of Gangliosides in Glycosylphosphatidylinositol-anchored Neuronal Cell Adhesion Molecule TAG-1 Signaling in Lipid Rafts J. Biol. Chem., October 27, 2000; 275(44): 34701 - 34709. [Abstract] [Full Text] [PDF]
|
|
