|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 117, Issue 2 525-533, Copyright © 1993 by Company of Biologists
JOURNAL ARTICLES |
NP Pringle and WD Richardson
Department of Biology, University College London, UK.
During rat embryogenesis, PDGF alpha receptor (PDGF-alpha R) mRNA is expressed in the ventral half of the spinal cord in two longitudinal columns, one each side of the central canal. Initially, these columns are only two cells wide but the cells subsequently appear to proliferate and disseminate throughout the spinal cord. Our previous studies of PDGF-alpha R expression in the developing CNS suggested that PDGF-alpha R may be a useful marker of the oligodendrocyte lineage in situ. The data presented here complement those studies and lead us to propose that the earliest oligodendrocyte precursors in the spinal cord originate in a very restricted region of the ventricular zone during a brief window of time around embryonic day 14 (E14). In the embryonic brain, migrating PDGF-alpha R+ cells appear to originate in a localized germinal zone in the ventral diencephalon (beneath the foramen of Monro). Our data demonstrate that gene expression and cell fate can be regulated with exquisite spatial resolution along the dorsoventral axis of the mammalian neural tube.
This article has been cited by other articles:
|
|
 |
|
  M. C. Tuason, A. Rastikerdar, T. Kuhlmann, C. Goujet-Zalc, B. Zalc, S. Dib, H. Friedman, and A. Peterson Separate Proteolipid Protein/DM20 Enhancers Serve Different Lineages and Stages of Development J. Neurosci., July 2, 2008; 28(27): 6895 - 6903. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Andrae, R. Gallini, and C. Betsholtz Role of platelet-derived growth factors in physiology and medicine Genes & Dev., May 15, 2008; 22(10): 1276 - 1312. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Parras, C. Hunt, M. Sugimori, M. Nakafuku, D. Rowitch, and F. Guillemot The Proneural Gene Mash1 Specifies an Early Population of Telencephalic Oligodendrocytes J. Neurosci., April 18, 2007; 27(16): 4233 - 4242. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Menn, J. M. Garcia-Verdugo, C. Yaschine, O. Gonzalez-Perez, D. Rowitch, and A. Alvarez-Buylla Origin of oligodendrocytes in the subventricular zone of the adult brain. J. Neurosci., July 26, 2006; 26(30): 7907 - 7918. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. H. Larsen, A. G. DaSilva, K. Conant, and V. W. Yong Myelin formation during development of the CNS is delayed in matrix metalloproteinase-9 and -12 null mice. J. Neurosci., February 22, 2006; 26(8): 2207 - 2214. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-H. Tsai, W. B. Macklin, and R. H. Miller Netrin-1 Is Required for the Normal Development of Spinal Cord Oligodendrocytes J. Neurosci., February 15, 2006; 26(7): 1913 - 1922. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Wu, Y. Wu, and M. R. Capecchi Motoneurons and oligodendrocytes are sequentially generated from neural stem cells but do not appear to share common lineage-restricted progenitors in vivo Development, February 15, 2006; 133(4): 581 - 590. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Fogarty, W. D. Richardson, and N. Kessaris A subset of oligodendrocytes generated from radial glia in the dorsal spinal cord Development, April 15, 2005; 132(8): 1951 - 1959. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. McKinnon, S. Waldron, and M. E. Kiel PDGF {alpha}-Receptor Signal Strength Controls an RTK Rheostat That Integrates Phosphoinositol 3'-Kinase and Phospholipase C{gamma} Pathways during Oligodendrocyte Maturation J. Neurosci., April 6, 2005; 25(14): 3499 - 3508. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Chojnacki and S. Weiss Isolation of a Novel Platelet-Derived Growth Factor-Responsive Precursor from the Embryonic Ventral Forebrain J. Neurosci., December 1, 2004; 24(48): 10888 - 10899. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. C. Stolt, P. Lommes, R. P. Friedrich, and M. Wegner Transcription factors Sox8 and Sox10 perform non-equivalent roles during oligodendrocyte development despite functional redundancy Development, May 15, 2004; 131(10): 2349 - 2358. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Jarjour and T. E. Kennedy Oligodendrocyte Precursors on the Move: Mechanisms Directing Migration Neuroscientist, April 1, 2004; 10(2): 99 - 105. [Abstract] [PDF]
|
|
|
|
|
|
N. Kessaris, F. Jamen, L. L. Rubin, and W. D. Richardson Cooperation between sonic hedgehog and fibroblast growth factor/MAPK signalling pathways in neocortical precursors Development, March 15, 2004; 131(6): 1289 - 1298. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Chandran, H. Kato, D. Gerreli, A. Compston, C. N. Svendsen, and N. D. Allen FGF-dependent generation of oligodendrocytes by a hedgehog-independent pathway Development, December 29, 2003; 130(26): 6599 - 6609. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Liu, J. Cai, X. Hu, M. Tan, Y. Qi, M. German, J. Rubenstein, M. Sander, and M. Qiu Region-specific and stage-dependent regulation of Olig gene expression and oligodendrogenesis by Nkx6.1 homeodomain transcription factor Development, December 22, 2003; 130(25): 6221 - 6231. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Moreau-Fauvarque, A. Kumanogoh, E. Camand, C. Jaillard, G. Barbin, I. Boquet, C. Love, E. Y. Jones, H. Kikutani, C. Lubetzki, et al. The Transmembrane Semaphorin Sema4D/CD100, an Inhibitor of Axonal Growth, Is Expressed on Oligodendrocytes and Upregulated after CNS Lesion J. Neurosci., October 8, 2003; 23(27): 9229 - 9239. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Imitola, E. Y. Snyder, and S. J. Khoury Genetic programs and responses of neural stem/progenitor cells during demyelination: potential insights into repair mechanisms in multiple sclerosis Physiol Genomics, August 15, 2003; 14(3): 171 - 197. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. G Mastronardi, L. A. daCruz, H. Wang, J. Boggs, and M. A Moscarello The amount of sonic hedgehog in multiple sclerosis white matter is decreased and cleavage to the signaling peptide is deficient Multiple Sclerosis, August 1, 2003; 9(4): 362 - 371. [Abstract] [PDF]
|
|
|
|
 |
|
 T. G. Hamilton, R. A. Klinghoffer, P. D. Corrin, and P. Soriano Evolutionary Divergence of Platelet-Derived Growth Factor Alpha Receptor Signaling Mechanisms Mol. Cell. Biol., June 1, 2003; 23(11): 4013 - 4025. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Jarjour, C. Manitt, S. W. Moore, K. M. Thompson, S.-J. Yuh, and T. E. Kennedy Netrin-1 Is a Chemorepellent for Oligodendrocyte Precursor Cells in the Embryonic Spinal Cord J. Neurosci., May 1, 2003; 23(9): 3735 - 3744. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Mekki-Dauriac, E. Agius, P. Kan, and P. Cochard Bone morphogenetic proteins negatively control oligodendrocyte precursor specification in the chick spinal cord Development, March 13, 2003; 129(22): 5117 - 5130. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. G. Marshall and J. E. Goldman Subpallial Dlx2-Expressing Cells Give Rise to Astrocytes and Oligodendrocytes in the Cerebral Cortex and White Matter J. Neurosci., November 15, 2002; 22(22): 9821 - 9830. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Billon, C. Jolicoeur, Q. L. Ying, A. Smith, and M. Raff Normal timing of oligodendrocyte development from genetically engineered, lineage-selectable mouse ES cells J. Cell Sci., September 15, 2002; 115(18): 3657 - 3665. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Genoud, C. Lappe-Siefke, S. Goebbels, F. Radtke, M. Aguet, S. S. Scherer, U. Suter, K.-A. Nave, and N. Mantei Notch1 control of oligodendrocyte differentiation in the spinal cord J. Cell Biol., August 19, 2002; 158(4): 709 - 718. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Fu, Y. Qi, M. Tan, J. Cai, H. Takebayashi, M. Nakafuku, W. Richardson, and M. Qiu Dual origin of spinal oligodendrocyte progenitors and evidence for the cooperative role of Olig2 and Nkx2.2 in the control of oligodendrocyte differentiation Development, January 2, 2002; 129(3): 681 - 693. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Gregori, C. Proschel, M. Noble, and M. Mayer-Proschel The Tripotential Glial-Restricted Precursor (GRP) Cell and Glial Development in the Spinal Cord: Generation of Bipotential Oligodendrocyte-Type-2 Astrocyte Progenitor Cells and Dorsal-Ventral Differences in GRP Cell Function J. Neurosci., January 1, 2002; 22(1): 248 - 256. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Spassky, K. Heydon, A. Mangatal, A. Jankovski, C. Olivier, F. Queraud-Lesaux, C. Goujet-Zalc, J. L. Thomas, and B. Zalc Sonic hedgehog-dependent emergence of oligodendrocytes in the telencephalon: evidence for a source of oligodendrocytes in the olfactory bulb that is independent of PDGFR{alpha} signaling Development, December 15, 2001; 128(24): 4993 - 5004. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Dahmane, P. Sanchez, Y. Gitton, V. Palma, T. Sun, M. Beyna, H. Weiner, and A. Ruiz i Altaba The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis Development, December 15, 2001; 128(24): 5201 - 5212. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. He, C. Ingraham, L. Rising, S. Goderie, and S. Temple Multipotent Stem Cells from the Mouse Basal Forebrain Contribute GABAergic Neurons and Oligodendrocytes to the Cerebral Cortex during Embryogenesis J. Neurosci., November 15, 2001; 21(22): 8854 - 8862. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Qi, J. Cai, Y. Wu, R. Wu, J. Lee, H. Fu, M. Rao, L. Sussel, J. Rubenstein, and M. Qiu Control of oligodendrocyte differentiation by the Nkx2.2 homeodomain transcription factor Development, July 15, 2001; 128(14): 2723 - 2733. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Tekki-Kessaris, R. Woodruff, A. C. Hall, W. Gaffield, S. Kimura, C. D. Stiles, D. H. Rowitch, and W. D. Richardson Hedgehog-dependent oligodendrocyte lineage specification in the telencephalon Development, July 1, 2001; 128(13): 2545 - 2554. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C Olivier, I Cobos, E. Perez Villegas, N Spassky, B Zalc, S Martinez, and J. Thomas Monofocal origin of telencephalic oligodendrocytes in the anterior entopeduncular area of the chick embryo Development, January 5, 2001; 128(10): 1757 - 1769. [Abstract] [PDF]
|
|
|
|
|
|
C Soula, C Danesin, P Kan, M Grob, C Poncet, and P Cochard Distinct sites of origin of oligodendrocytes and somatic motoneurons in the chick spinal cord: oligodendrocytes arise from Nkx2.2-expressing progenitors by a Shh-dependent mechanism Development, January 4, 2001; 128(8): 1369 - 1379. [Abstract] [PDF]
|
|
|
|
|
|
S Nery, H Wichterle, and G Fishell Sonic hedgehog contributes to oligodendrocyte specification in the mammalian forebrain Development, January 2, 2001; 128(4): 527 - 540. [Abstract] [PDF]
|
|
|
|
|
|
A. Chang, A. Nishiyama, J. Peterson, J. Prineas, and B. D. Trapp NG2-Positive Oligodendrocyte Progenitor Cells in Adult Human Brain and Multiple Sclerosis Lesions J. Neurosci., September 1, 2000; 20(17): 6404 - 6412. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Wu, R. H. Miller, R. M. Ransohoff, S. Robinson, J. Bu, and A. Nishiyama Elevated Levels of the Chemokine GRO-1 Correlate with Elevated Oligodendrocyte Progenitor Proliferation in the Jimpy Mutant J. Neurosci., April 1, 2000; 20(7): 2609 - 2617. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. G. Tang, Y. M. Tokumoto, and M. C. Raff Long-Term Culture of Purified Postnatal Oligodendrocyte Precursor Cells: Evidence for an Intrinsic Maturation Program that Plays out over Months J. Cell Biol., March 6, 2000; 148(5): 971 - 984. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Metin, J.-P. Denizot, and N. Ropert Intermediate Zone Cells Express Calcium-Permeable AMPA Receptors and Establish Close Contact with Growing Axons J. Neurosci., January 15, 2000; 20(2): 696 - 708. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T Sun, D Jayatilake, G. Afink, P Ataliotis, M Nister, W. Richardson, and H. Smith A human YAC transgene rescues craniofacial and neural tube development in PDGFRalpha knockout mice and uncovers a role for PDGFRalpha in prenatal lung growth Development, January 11, 2000; 127(21): 4519 - 4529. [Abstract] [PDF]
|
|
|
|
|
|
D. H. Rowitch, B. St.-Jacques, S. M. K. Lee, J. D. Flax, E. Y. Snyder, and A. P. McMahon Sonic hedgehog Regulates Proliferation and Inhibits Differentiation of CNS Precursor Cells J. Neurosci., October 15, 1999; 19(20): 8954 - 8965. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-H. Heldin and B. Westermark Mechanism of Action and In Vivo Role of Platelet-Derived Growth Factor Physiol Rev, October 1, 1999; 79(4): 1283 - 1316. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Niehaus, J. Stegmuller, M. Diers-Fenger, and J. Trotter Cell-Surface Glycoprotein of Oligodendrocyte Progenitors Involved in Migration J. Neurosci., June 15, 1999; 19(12): 4948 - 4961. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Bessert and R. P. Skoff High-resolution In Situ Hybridization and TUNEL Staining with Free-floating Brain Sections J. Histochem. Cytochem., May 1, 1999; 47(5): 693 - 702. [Abstract] [Full Text]
|
|
|
|
 |
|
 T. Vartanian, G. Fischbach, and R. Miller Failure of spinal cord oligodendrocyte development in mice lacking neuregulin PNAS, January 19, 1999; 96(2): 731 - 735. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. J. Chandross, R. I. Cohen, P. Paras Jr, M. Gravel, P. E. Braun, and L. D. Hudson Identification and Characterization of Early Glial Progenitors Using a Transgenic Selection Strategy J. Neurosci., January 15, 1999; 19(2): 759 - 774. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D Arendt and K Nubler-Jung Comparison of early nerve cord development in insects and vertebrates Development, January 6, 1999; 126(11): 2309 - 2325. [Abstract] [PDF]
|
|
|
|
|
|
D. Orentas, J. Hayes, K. Dyer, and R. Miller Sonic hedgehog signaling is required during the appearance of spinal cord oligodendrocyte precursors Development, January 6, 1999; 126(11): 2419 - 2429. [Abstract] [PDF]
|
|
|
|
|
|
M Fruttiger, L Karlsson, A. Hall, A Abramsson, A. Calver, H Bostrom, K Willetts, C. Bertold, J. Heath, C Betsholtz, et al. Defective oligodendrocyte development and severe hypomyelination in PDGF-A knockout mice Development, January 2, 1999; 126(3): 457 - 467. [Abstract] [PDF]
|
|
|
|
|
|
S. Robinson, M. Tani, R. M. Strieter, R. M. Ransohoff, and R. H. Miller The Chemokine Growth-Regulated Oncogene-alpha Promotes Spinal Cord Oligodendrocyte Precursor Proliferation J. Neurosci., December 15, 1998; 18(24): 10457 - 10463. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Spassky, C. Goujet-Zalc, E. Parmantier, C. Olivier, S. Martinez, A. Ivanova, K. Ikenaka, W. Macklin, I. Cerruti, B. Zalc, et al. Multiple Restricted Origin of Oligodendrocytes J. Neurosci., October 15, 1998; 18(20): 8331 - 8343. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Yamada, M. Watanabe, T. Shibata, M. Nagashima, K. Tanaka, and Y. Inoue Glutamate Transporter GLT-1 Is Transiently Localized on Growing Axons of the Mouse Spinal Cord before Establishing Astrocytic Expression J. Neurosci., August 1, 1998; 18(15): 5706 - 5713. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kuhlbrodt, B. Herbarth, E. Sock, I. Hermans-Borgmeyer, and M. Wegner Sox10, a Novel Transcriptional Modulator in Glial Cells J. Neurosci., January 1, 1998; 18(1): 237 - 250. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Osterhout, S. Ebner, J. Xu, D. M. Ornitz, G. A. Zazanis, and R. D. McKinnon Transplanted Oligodendrocyte Progenitor Cells Expressing a Dominant-Negative FGF Receptor Transgene Fail to Migrate In Vivo J. Neurosci., December 1, 1997; 17(23): 9122 - 9132. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Takakura, H. Yoshida, Y. Ogura, H. Kataoka, S. Nishikawa, and S.-I. Nishikawa PDGFR{alpha} Expression During Mouse Embryogenesis: Immunolocalization Analyzed by Whole-mount Immunohistostaining Using the Monoclonal Anti-mouse PDGFR{alpha} Antibody APA5 J. Histochem. Cytochem., June 1, 1997; 45(6): 883 - 894. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. D. Trapp, A. Nishiyama, D. Cheng, and W. Macklin Differentiation and Death of Premyelinating Oligodendrocytes in Developing Rodent Brain J. Cell Biol., April 21, 1997; 137(2): 459 - 468. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Burrill, L Moran, M. Goulding, and H Saueressig PAX2 is expressed in multiple spinal cord interneurons, including a population of EN1+ interneurons that require PAX6 for their development Development, January 11, 1997; 124(22): 4493 - 4503. [Abstract] [PDF]
|
|
|
|
|
|
B. N. Oumesmar, L. Vignais, and A. Baron-Van Evercooren Developmental Expression of Platelet-Derived Growth Factor alpha -Receptor in Neurons and Glial Cells of the Mouse CNS J. Neurosci., January 1, 1997; 17(1): 125 - 139. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Zhang and R. H. Miller Density-Dependent Feedback Inhibition of Oligodendrocyte Precursor Expansion J. Neurosci., November 1, 1996; 16(21): 6886 - 6895. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A Hall, N. Giese, and W. Richardson Spinal cord oligodendrocytes develop from ventrally derived progenitor cells that express PDGF alpha-receptors Development, January 12, 1996; 122(12): 4085 - 4094. [Abstract] [PDF]
|
|
|
|
|
|
R. Hardy and V. Friedrich Oligodendrocyte progenitors are generated throughout the embryonic mouse brain, but differentiate in restricted foci Development, January 7, 1996; 122(7): 2059 - 2069. [Abstract] [PDF]
|
|
|
|
|
|
A Webb, P Clark, J Skepper, A Compston, and A Wood Guidance of oligodendrocytes and their progenitors by substratum topography J. Cell Sci., January 8, 1995; 108(8): 2747 - 2760. [Abstract] [PDF]
|
|
|
|
|
|
K Ono, R Bansal, J Payne, U Rutishauser, and R. Miller Early development and dispersal of oligodendrocyte precursors in the embryonic chick spinal cord Development, January 6, 1995; 121(6): 1743 - 1754. [Abstract] [PDF]
|
|
|
|
|
|
