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Development, Vol 117, Issue 2 571-584, Copyright © 1993 by Company of Biologists
JOURNAL ARTICLES |
JA Williams, SW Paddock and SB Carroll
Howard Hughes Medical Institute, University of Wisconsin-Madison 53706.
The legs and wings of insects and vertebrates develop from secondary embryonic fields that arise after the primary body axes have been established. In order to understand how the insect imaginal wing field is patterned, we have examined in detail the temporal and spatial expression patterns of, and epistatic relationships between, four key regulatory genes that are specifically required for wing formation in Drosophila. The wingless protein, in a role surprisingly distinct from its embryonic segment polarity function, appears to be the earliest-acting member of the hierarchy and crucial for distinguishing the notum/wing subfields, and for the compartmentalization of the dorsal and ventral wing surfaces. The wingless product is required to restrict the expression of the apterous gene to dorsal cells and to promote the expression of the vestigial and scalloped genes that demarcate the wing primordia and act in concert to promote morphogenesis.
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H McNeill, C H Yang, M Brodsky, J Ungos, and M A Simon mirror encodes a novel PBX-class homeoprotein that functions in the definition of the dorsal-ventral border in the Drosophila eye. Genes & Dev., April 15, 1997; 11(8): 1073 - 1082. [Abstract] [PDF]
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J. Cygan, R. Johnson, and A. McMahon Novel regulatory interactions revealed by studies of murine limb pattern in Wnt-7a and En-1 mutants Development, January 12, 1997; 124(24): 5021 - 5032. [Abstract] [PDF]
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C. Micchelli, E. Rulifson, and S. Blair The function and regulation of cut expression on the wing margin of Drosophila: Notch, Wingless and a dominant negative role for Delta and Serrate Development, January 4, 1997; 124(8): 1485 - 1495. [Abstract] [PDF]
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C. Neumann and S. Cohen Long-range action of Wingless organizes the dorsal-ventral axis of the Drosophila wing Development, January 2, 1997; 124(4): 871 - 880. [Abstract] [PDF]
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E. Chen and B. Baker Compartmental organization of the Drosophila genital imaginal discs Development, January 1, 1997; 124(1): 205 - 218. [Abstract] [PDF]
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D Doherty, G Feger, S Younger-Shepherd, L Y Jan, and Y N Jan Delta is a ventral to dorsal signal complementary to Serrate, another Notch ligand, in Drosophila wing formation. Genes & Dev., February 15, 1996; 10(4): 421 - 434. [Abstract] [PDF]
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H Theisen, T. Haerry, M. O'Connor, and J. Marsh Developmental territories created by mutual antagonism between Wingless and Decapentaplegic Development, January 12, 1996; 122(12): 3939 - 3948. [Abstract] [PDF]
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C. Neumann and S. Cohen A hierarchy of cross-regulation involving Notch, wingless, vestigial and cut organizes the dorsal/ventral axis of the Drosophila wing Development, January 11, 1996; 122(11): 3477 - 3485. [Abstract] [PDF]
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J. de Celis, A Garcia-Bellido, and S. Bray Activation and function of Notch at the dorsal-ventral boundary of the wing imaginal disc Development, January 1, 1996; 122(1): 359 - 369. [Abstract] [PDF]
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E. H. Davidson, K. J. Peterson, and R. A. Cameron Origin of Bilaterian Body Plans: Evolution of Developmental Regulatory Mechanisms Science, November 24, 1995; 270(5240): 1319 - 1325. [Abstract] [PDF]
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F. Diaz-Benjumea and S. Cohen Serrate signals through Notch to establish a Wingless-dependent organizer at the dorsal/ventral compartment boundary of the Drosophila wing Development, January 12, 1995; 121(12): 4215 - 4225. [Abstract] [PDF]
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