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Development, Vol 118, Issue 3 989-1001, Copyright © 1993 by Company of Biologists
JOURNAL ARTICLES |
VL Buchman and AM Davies
Department of Anatomy, St. George's Hospital Medical School, Tooting, London, UK.
To investigate if different neurotrophins regulate the survival of neurons at successive developmental stages, we studied the effect of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) on the survival of mouse trigeminal neurons at closely staged intervals in development. We show that during the earliest stages of target field innervation trigeminal neurons display a transitory survival response to BDNF and NT-3. This response is lost as the neurons become NGF-dependent shortly before neuronal death begins in the trigeminal ganglion. BDNF and NT-3 mRNAs are expressed in the peripheral trigeminal target field before the arrival of the earliest axons and the onset of NGF mRNA expression. The levels of BDNF and NT-3 mRNAs peak during the early stages of target field innervation and decline shortly after the loss of neuronal responsiveness to BDNF and NT-3. Our study provides the first clear evidence that different target-derived neurotrophins can act sequentially to promote the survival of developing neurons.
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S. McKay, a Garner, J Caldero, R. Tucker, T Large, and R. Oppenheim The expression of trkB and p75 and the role of BDNF in the developing neuromuscular system of the chick embryo Development, January 2, 1996; 122(2): 715 - 724. [Abstract] [PDF]
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M Ockel, G. Lewin, and Y. Barde In vivo effects of neurotrophin-3 during sensory neurogenesis Development, January 1, 1996; 122(1): 301 - 307. [Abstract] [PDF]
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A Buj-Bello, L. Pinon, and A. Davies The survival of NGF-dependent but not BDNF-dependent cranial sensory neurons is promoted by several different neurotrophins early in their development Development, January 6, 1994; 120(6): 1573 - 1580. [Abstract] [PDF]
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F Gaese, R Kolbeck, and Y. Barde Sensory ganglia require neurotrophin-3 early in development Development, January 6, 1994; 120(6): 1613 - 1619. [Abstract] [PDF]
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V. Buchman, M Sporn, and A. Davies Role of transforming growth factor-beta isoforms in regulating the expression of nerve growth factor and neurotrophin-3 mRNA levels in embryonic cutaneous cells at different stages of development Development, January 6, 1994; 120(6): 1621 - 1629. [Abstract] [PDF]
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S Wyatt and A. Davies Regulation of expression of mRNAs encoding the nerve growth factor receptors p75 and trkA in developing sensory neurons Development, January 11, 1993; 119(3): 635 - 648. [Abstract] [PDF]
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