|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 119, Issue 4 1161-1173, Copyright © 1993 by Company of Biologists
JOURNAL ARTICLES |
M Ku and DA Melton
Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, MA 02138.
We have isolated and characterized a novel Xenopus wnt gene, Xwnt-11, whose expression pattern and overexpression phenotype suggest that it may be important for dorsal-ventral axis formation. Xwnt-11 mRNA is present during oogenesis and embryonic development through swimming tadpole stages. Xwnt-11 mRNA is ubiquitous in early oocytes and is localized during mid-oogenesis. By late oocyte stages, Xwnt-11 mRNA is localized to the vegetal cortex, with some mRNA in the vegetal cytoplasm. After egg maturation, Xwnt-11 mRNA is released from the vegetal cortex and is found in the vegetal cytoplasm. This early pattern of Xwnt-11 mRNA localization is similar to another vegetally localized maternal mRNA, Vg1 (D. A. Melton (1987) Nature 328, 80-82). In the late blastula, Xwnt-11 mRNA is found at high levels in the dorsal marginal zone. As gastrulation proceeds, Xwnt-11 mRNA appears in the lateral and ventral marginal zone and, during tadpole stages, it is found in the somites and first branchial arch. Injection of Xwnt-11 mRNA into UV-ventralized embryos can substantially rescue the UV defect by inducing the formation of dorsal tissues. The rescued embryos develop somitic muscle and neural tube; however, they lack notochord and anterior head structures.
This article has been cited by other articles:
|
|
 |
|
  B. A. Afouda, J. Martin, F. Liu, A. Ciau-Uitz, R. Patient, and S. Hoppler GATA transcription factors integrate Wnt signalling during heart development Development, October 1, 2008; 135(19): 3185 - 3190. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Brade, J. Manner, and M. Kuhl The role of Wnt signalling in cardiac development and tissue remodelling in the mature heart Cardiovasc Res, November 1, 2006; 72(2): 198 - 209. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Heasman Patterning the early Xenopus embryo. Development, April 1, 2006; 133(7): 1205 - 1217. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. De Calisto, C. Araya, L. Marchant, C. F. Riaz, and R. Mayor Essential role of non-canonical Wnt signalling in neural crest migration Development, June 1, 2005; 132(11): 2587 - 2597. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kloc and L. D. Etkin RNA localization mechanisms in oocytes J. Cell Sci., January 15, 2005; 118(2): 269 - 282. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Waxman, A. M. Hocking, C. L. Stoick, and R. T. Moon Zebrafish Dapper1 and Dapper2 play distinct roles in Wnt-mediated developmental processes Development, December 1, 2004; 131(23): 5909 - 5921. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. J. Yoon and K. L. Mowry Xenopus Staufen is a component of a ribonucleoprotein complex containing Vg1 RNA and kinesin Development, July 1, 2004; 131(13): 3035 - 3045. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Davidson and M. Levine Evolutionary origins of the vertebrate heart: Specification of the cardiac lineage in Ciona intestinalis PNAS, September 30, 2003; 100(20): 11469 - 11473. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Ohkawara, T. S. Yamamoto, M. Tada, and N. Ueno Role of glypican 4 in the regulation of convergent extension movements during gastrulation in Xenopus laevis Development, May 15, 2003; 130(10): 2129 - 2138. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Hikasa, M. Shibata, I. Hiratani, and M. Taira The Xenopus receptor tyrosine kinase Xror2 modulates morphogenetic movements of the axial mesoderm and neuroectoderm via Wnt signaling Development, March 13, 2003; 129(22): 5227 - 5239. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. van Gijn, M. J.A.P. Daemen, J. F.M. Smits, and W.M. Blankesteijn The wnt-frizzled cascade in cardiovascular disease Cardiovasc Res, July 1, 2002; 55(1): 16 - 24. [Full Text] [PDF]
|
|
|
|
|
|
A. Schohl and F. Fagotto {beta}-catenin, MAPK and Smad signaling during early Xenopus development Development, January 1, 2002; 129(1): 37 - 52. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Kiecker and C. Niehrs A morphogen gradient of Wnt/{beta}-catenin signalling regulates anteroposterior neural patterning in Xenopus Development, November 1, 2001; 128(21): 4189 - 4201. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. L. Conlon, L. Fairclough, B. M. J. Price, E. S. Casey, and J. C. Smith Determinants of T box protein specificity Development, October 1, 2001; 128(19): 3749 - 3758. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Nakamura, R. Amikura, K. Hanyu, and S. Kobayashi Me31B silences translation of oocyte-localizing RNAs through the formation of cytoplasmic RNP complex during Drosophila oogenesis Development, September 1, 2001; 128(17): 3233 - 3242. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Skromne and C. D. Stern Interactions between Wnt and Vg1 signalling pathways initiate primitive streak formation in the chick embryo Development, August 1, 2001; 128(15): 2915 - 2927. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. A. Schneider and M. Mercola Wnt antagonism initiates cardiogenesis in Xenopus laevis Genes & Dev., February 1, 2001; 15(3): 304 - 315. [Abstract] [Full Text]
|
|
|
|
|
|
V. Alarcon and R. Elinson RNA anchoring in the vegetal cortex of the Xenopus oocyte J. Cell Sci., January 5, 2001; 114(9): 1731 - 1741. [Abstract] [PDF]
|
|
|
|
|
|
M. Tada and J. C. Smith Xwnt11 is a target of Xenopus Brachyury: regulation of gastrulation movements via Dishevelled, but not through the canonical Wnt pathway Development, May 15, 2000; 127(10): 2227 - 2238. [Abstract] [PDF]
|
|
|
|
|
|
A Djiane, J Riou, M Umbhauer, J Boucaut, and D Shi Role of frizzled 7 in the regulation of convergent extension movements during gastrulation in Xenopus laevis Development, January 7, 2000; 127(14): 3091 - 3100. [Abstract] [PDF]
|
|
|
|
|
|
S Sumanas, P Strege, J Heasman, and S. Ekker The putative wnt receptor Xenopus frizzled-7 functions upstream of beta-catenin in vertebrate dorsoventral mesoderm patterning Development, January 5, 2000; 127(9): 1981 - 1990. [Abstract] [PDF]
|
|
|
|
|
|
K. Itoh and S. Y. Sokol Axis determination by inhibition of Wnt signaling in Xenopus Genes & Dev., September 1, 1999; 13(17): 2328 - 2336. [Abstract] [Full Text]
|
|
|
|
|
|
A. Chan, M Kloc, and L. Etkin fatvg encodes a new localized RNA that uses a 25-nucleotide element (FVLE1) to localize to the vegetal cortex of Xenopus oocytes Development, January 11, 1999; 126(22): 4943 - 4953. [Abstract] [PDF]
|
|
|
|
 |
|
 D. J. Van Den Berg, A. K. Sharma, E. Bruno, and R. Hoffman Role of Members of the Wnt Gene Family in Human Hematopoiesis Blood, November 1, 1998; 92(9): 3189 - 3202. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Deardorff, C Tan, L. Conrad, and P. Klein Frizzled-8 is expressed in the Spemann organizer and plays a role in early morphogenesis Development, January 7, 1998; 125(14): 2687 - 2700. [Abstract] [PDF]
|
|
|
|
|
|
T. W. Austin, G. P. Solar, F. C. Ziegler, L. Liem, and W. Matthews A Role for the Wnt Gene Family in Hematopoiesis: Expansion of Multilineage Progenitor Cells Blood, May 15, 1997; 89(10): 3624 - 3635. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Laurent, I. Blitz, C Hashimoto, U Rothbacher, and K. Cho The Xenopus homeobox gene twin mediates Wnt induction of goosecoid in establishment of Spemann's organizer Development, January 12, 1997; 124(23): 4905 - 4916. [Abstract] [PDF]
|
|
|
|
|
|
D Gautreau, C. Cote, and K. Mowry Two copies of a subelement from the Vg1 RNA localization sequence are sufficient to direct vegetal localization in Xenopus oocytes Development, January 12, 1997; 124(24): 5013 - 5020. [Abstract] [PDF]
|
|
|
|
|
|
J Heasman Patterning the Xenopus blastula Development, January 11, 1997; 124(21): 4179 - 4191. [Abstract] [PDF]
|
|
|
|
|
|
C Marcelle, M. Stark, and M Bronner-Fraser Coordinate actions of BMPs, Wnts, Shh and noggin mediate patterning of the dorsal somite Development, January 10, 1997; 124(20): 3955 - 3963. [Abstract] [PDF]
|
|
|
|
|
|
M. Horb and G. Thomsen A vegetally localized T-box transcription factor in Xenopus eggs specifies mesoderm and endoderm and is essential for embryonic mesoderm formation Development, January 5, 1997; 124(9): 1689 - 1698. [Abstract] [PDF]
|
|
|
|
|
|
F Fagotto, K Guger, and B. Gumbiner Induction of the primary dorsalizing center in Xenopus by the Wnt/GSK/beta-catenin signaling pathway, but not by Vg1, Activin or Noggin Development, January 1, 1997; 124(2): 453 - 460. [Abstract] [PDF]
|
|
|
|
|
|
C. Eisenberg, R. Gourdie, and L. Eisenberg Wnt-11 is expressed in early avian mesoderm and required for the differentiation of the quail mesoderm cell line QCE-6 Development, January 1, 1997; 124(2): 525 - 536. [Abstract] [PDF]
|
|
|
|
|
|
K. L. Mowry Complex formation between stage-specific oocyte factors and a Xenopus mRNA localization element PNAS, December 10, 1996; 93(25): 14608 - 14613. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C Yost, M Torres, J R Miller, E Huang, D Kimelman, and R T Moon The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3. Genes & Dev., June 15, 1996; 10(12): 1443 - 1454. [Abstract] [PDF]
|
|
|
|
|
|
M. Mullins, M Hammerschmidt, D. Kane, J Odenthal, M Brand, F. van Eeden, M Furutani-Seiki, M Granato, P Haffter, C. Heisenberg, et al. Genes establishing dorsoventral pattern formation in the zebrafish embryo: the ventral specifying genes Development, January 12, 1996; 123(1): 81 - 93. [Abstract] [PDF]
|
|
|
|
|
|
J Zhang and M. King Xenopus VegT RNA is localized to the vegetal cortex during oogenesis and encodes a novel T-box transcription factor involved in mesodermal patterning Development, January 12, 1996; 122(12): 4119 - 4129. [Abstract] [PDF]
|
|
|
|
|
|
F Stennard, G Carnac, and J. Gurdon The Xenopus T-box gene, Antipodean, encodes a vegetally localised maternal mRNA and can trigger mesoderm formation Development, January 12, 1996; 122(12): 4179 - 4188. [Abstract] [PDF]
|
|
|
|
|
|
C Wylie, M Kofron, C Payne, R Anderson, M Hosobuchi, E Joseph, and J Heasman Maternal beta-catenin establishes a 'dorsal signal' in early Xenopus embryos Development, January 10, 1996; 122(10): 2987 - 2996. [Abstract] [PDF]
|
|
|
|
|
|
Y Zhou and M. King Localization of Xcat-2 RNA, a putative germ plasm component, to the mitochondrial cloud in Xenopus stage I oocytes Development, January 9, 1996; 122(9): 2947 - 2953. [Abstract] [PDF]
|
|
|
|
|
|
G. Henry, I. Brivanlou, D. Kessler, A Hemmati-Brivanlou, and D. Melton TGF-beta signals and a pattern in Xenopus laevis endodermal development Development, January 3, 1996; 122(3): 1007 - 1015. [Abstract] [PDF]
|
|
|
|
|
|
T Watabe, S Kim, A Candia, U Rothbacher, C Hashimoto, K Inoue, and K W Cho Molecular mechanisms of Spemann's organizer formation: conserved growth factor synergy between Xenopus and mouse. Genes & Dev., December 15, 1995; 9(24): 3038 - 3050. [Abstract] [PDF]
|
|
|
|
|
|
A E Munsterberg, J Kitajewski, D A Bumcrot, A P McMahon, and A B Lassar Combinatorial signaling by Sonic hedgehog and Wnt family members induces myogenic bHLH gene expression in the somite. Genes & Dev., December 1, 1995; 9(23): 2911 - 2922. [Abstract] [PDF]
|
|
|
|
|
|
T Holowacz and R. Elinson Properties of the dorsal activity found in the vegetal cortical cytoplasm of Xenopus eggs Development, January 9, 1995; 121(9): 2789 - 2798. [Abstract] [PDF]
|
|
|
|
|
|
S. Ekker, L. McGrew, C. Lai, J. Lee, D. von Kessler, R. Moon, and P. Beachy Distinct expression and shared activities of members of the hedgehog gene family of Xenopus laevis Development, January 8, 1995; 121(8): 2337 - 2347. [Abstract] [PDF]
|
|
|
|
|
|
Y Cui, J. Brown, R. Moon, and J. Christian Xwnt-8b: a maternally expressed Xenopus Wnt gene with a potential role in establishing the dorsoventral axis Development, January 7, 1995; 121(7): 2177 - 2186. [Abstract] [PDF]
|
|
|
|
|
|
K Kinoshita and M Asashima Effect of activin and lithium on isolated Xenopus animal blastomeres and response alteration at the midblastula transition Development, January 6, 1995; 121(6): 1581 - 1589. [Abstract] [PDF]
|
|
|
|
|
|
S. Sokol, J Klingensmith, N Perrimon, and K Itoh Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled Development, January 6, 1995; 121(6): 1637 - 1647. [Abstract] [PDF]
|
|
|
|
|
|
M Kloc and L. Etkin Two distinct pathways for the localization of RNAs at the vegetal cortex in Xenopus oocytes Development, January 2, 1995; 121(2): 287 - 297. [Abstract] [PDF]
|
|
|
|
|
|
C Forristall, M Pondel, L Chen, and M. King Patterns of localization and cytoskeletal association of two vegetally localized RNAs, Vg1 and Xcat-2 Development, January 1, 1995; 121(1): 201 - 208. [Abstract] [PDF]
|
|
|
|
 |
|
 D. Kessler and D. Melton Vertebrate embryonic induction: mesodermal and neural patterning Science, October 28, 1994; 266(5185): 596 - 604. [Abstract] [PDF]
|
|
|
|
|
|
F Fagotto and B. Gumbiner Beta-catenin localization during Xenopus embryogenesis: accumulation at tissue and somite boundaries Development, January 12, 1994; 120(12): 3667 - 3679. [Abstract] [PDF]
|
|
