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Development, Vol 119, Issue 4 1359-1369, Copyright © 1993 by Company of Biologists
JOURNAL ARTICLES |
TB Chou, E Noll and N Perrimon
Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115.
The 'dominant female-sterile' technique used to generate germ-line mosaics in Drosophila is a powerful tool to determine the tissue specificity (germ line versus somatic) of recessive female-sterile mutations as well as to analyze the maternal effect of recessive zygotic lethal mutations. This technique requires the availability of germ-line-dependent, dominant female-sterile (DFS) mutations that block egg laying but do not affect viability. To date only one X-linked mutation, ovoD1 has been isolated that completely fulfills these criteria. Thus the 'DFS technique' has been largely limited to the X-chromosome. To extend this technique to the autosomes, we have cloned the ovoD1 mutation into a P-element vector and recovered fully expressed P[ovoD1] insertions on each autosomal arm. We describe the generation of these P[ovoD1] strains as well as demonstrate their use in generating germ-line chimeras. Specifically, we show that the Gap1 gene, which encodes a Drosophila homologue of mammalian GTPase-activating protein, is required in somatic follicle cells for embryonic dorsoventral polarity determination.
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Z Liu, T Xie, and R Steward Lis1, the Drosophila homolog of a human lissencephaly disease gene, is required for germline cell division and oocyte differentiation Development, January 10, 1999; 126(20): 4477 - 4488. [Abstract] [PDF]
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M Buszczak, M. Freeman, J. Carlson, M Bender, L Cooley, and W. Segraves Ecdysone response genes govern egg chamber development during mid-oogenesis in Drosophila Development, January 10, 1999; 126(20): 4581 - 4589. [Abstract] [PDF]
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R. Goldstein, G Jimenez, O Cook, D Gur, and Z Paroush Huckebein repressor activity in Drosophila terminal patterning is mediated by Groucho Development, January 9, 1999; 126(17): 3747 - 3755. [Abstract] [PDF]
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