|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 120, Issue 1 209-218, Copyright © 1994 by Company of Biologists
JOURNAL ARTICLES |
PH Francis, MK Richardson, PM Brickell and C Tickle
Department of Anatomy and Developmental Biology, University College London Medical School, UK.
We show here that bone morphogenetic protein 2 (BMP-2) is involved in patterning the developing chick limb. During early stages of limb development, mesenchymal expression of the Bmp-2 gene is restricted to the posterior part of the bud, in a domain that colocalizes with the polarizing region. The polarizing region is a group of cells at the posterior margin of the limb bud that can respecify the anteroposterior axis of the limb when grafted anteriorly and can activate expression of genes of the HoxD complex. We dissect possible roles of BMP-2 in the polarizing region signalling pathway by manipulating the developing wing bud. Retinoic acid application, which mimics the effects of polarizing region grafts, activates Bmp-2 gene expression in anterior cells. This shows that changes in anteroposterior pattern are correlated with changes in Bmp-2 expression. When polarizing region grafts are placed at the anterior margin of the wing bud, the grafts continue to express the Bmp-2 gene and also activate Bmp-2 expression in the adjacent anterior host mesenchyme. These data suggest that BMP-2 is part of the response pathway to the polarizing signal, rather than being the signal itself. In support of this, BMP-2 protein does not appear to have any detectable polarizing activity when applied to the wing bud. The pattern of Bmp-4 gene expression in the developing wing bud raises the possibility that BMP-2 and BMP-4 could act in concert. There is a close relationship, both temporal and spatial, between the activation of the Bmp-2 and Hoxd-13 genes in response to retinoic acid and polarizing region grafts, suggesting that expression of the two genes might be linked.
This article has been cited by other articles:
|
|
 |
|
  J. M. Brito, M.-A. Teillet, and N. M. Le Douarin Induction of mirror-image supernumerary jaws in chicken mandibular mesenchyme by Sonic Hedgehog-producing cells Development, July 1, 2008; 135(13): 2311 - 2319. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Brito, M.-A. Teillet, and N. M. Le Douarin An early role for Sonic hedgehog from foregut endoderm in jaw development: Ensuring neural crest cell survival PNAS, August 1, 2006; 103(31): 11607 - 11612. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Lours and S. Dietrich The dissociation of the Fgf-feedback loop controls the limbless state of the neck Development, December 15, 2005; 132(24): 5553 - 5564. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R.T. Franceschi Biological Approaches to Bone Regeneration by Gene Therapy J. Dent. Res., December 1, 2005; 84(12): 1093 - 1103. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. H. Evans and R. N. Rosier Molecular Biology in Orthopaedics: The Advent of Molecular Orthopaedics J. Bone Joint Surg. Am., November 1, 2005; 87(11): 2550 - 2564. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Rallis, J. Del Buono, and M. P. O. Logan Tbx3 can alter limb position along the rostrocaudal axis of the developing embryo Development, April 15, 2005; 132(8): 1961 - 1970. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. T. Fritz, D. Liu, J. Xu, S. Jiang, and M. B. Rogers Conservation of Bmp2 Post-transcriptional Regulatory Mechanisms J. Biol. Chem., November 19, 2004; 279(47): 48950 - 48958. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. M. Knosp, V. Scott, H. P. Bachinger, and H. S. Stadler HOXA13 regulates the expression of bone morphogenetic proteins 2 and 7 to control distal limb morphogenesis Development, September 15, 2004; 131(18): 4581 - 4592. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Fliniaux, J. P. Viallet, and D. Dhouailly Signaling dynamics of feather tract formation from the chick somatopleure Development, August 15, 2004; 131(16): 3955 - 3966. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Mandler and A. Neubuser FGF signaling is required for initiation of feather placode development Development, July 15, 2004; 131(14): 3333 - 3343. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L. Abrams, J. Xu, C. Nativelle-Serpentini, S. Dabirshahsahebi, and M. B. Rogers An Evolutionary and Molecular Analysis of Bmp2 Expression J. Biol. Chem., April 16, 2004; 279(16): 15916 - 15928. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. E. Bobick and W. M. Kulyk The MEK-ERK Signaling Pathway Is a Negative Regulator of Cartilage-specific Gene Expression in Embryonic Limb Mesenchyme J. Biol. Chem., February 6, 2004; 279(6): 4588 - 4595. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A H Reddi Cartilage morphogenetic proteins: role in joint development, homoeostasis, and regeneration Ann Rheum Dis, November 1, 2003; 62(90002): ii73 - 78. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. G. Buxton, B. Hall, C. W. Archer, and P. Francis-West Secondary chondrocyte-derived Ihh stimulates proliferation of periosteal cells during chick development Development, October 1, 2003; 130(19): 4729 - 4739. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Endo, N. Osumi, and Y. Wakamatsu Bimodal functions of Notch-mediated signaling are involved in neural crest formation during avian ectoderm development Development, March 4, 2003; 129(4): 863 - 873. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Ghatpande, A. Ghatpande, J. Sher, M. H. Zile, and T. Evans Retinoid signaling regulates primitive (yolk sac) hematopoiesis Blood, April 1, 2002; 99(7): 2379 - 2386. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Freitas, S. Rodrigues, J.-B. Charrier, M.-A. Teillet, and I. Palmeirim Evidence for medial/lateral specification and positional information within the presomitic mesoderm Development, December 15, 2001; 128(24): 5139 - 5147. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Pizette, C. Abate-Shen, and L. Niswander BMP controls proximodistal outgrowth, via induction of the apical ectodermal ridge, and dorsoventral patterning in the vertebrate limb Development, November 15, 2001; 128(22): 4463 - 4474. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-B. Charrier, F. Lapointe, N. M. L. Douarin, and M.-A. Teillet Anti-apoptotic role of Sonic hedgehog protein at the early stages of nervous system organogenesis Development, October 15, 2001; 128(20): 4011 - 4020. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-C. Lu, E. C. Swindell, W. D. Sierralta, G. Eichele, and C. Thaller Evidence for a role of protein kinase C in FGF signal transduction in the developing chick limb bud Development, July 1, 2001; 128(13): 2451 - 2460. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Buxton, C. Edwards, C. W. Archer, and P. Francis-West Growth/Differentiation Factor-5 (GDF-5) and Skeletal Development J. Bone Joint Surg. Am., April 1, 2001; 83(90010): S23 - 30. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Buxton, C. Edwards, C. W. Archer, and P. Francis-West Growth/Differentiation Factor-5 (GDF-5) and Skeletal Development J. Bone Joint Surg. Am., March 1, 2001; 83(1_suppl_1): S23 - S30. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Trousse, P. Esteve, and P. Bovolenta BMP4 Mediates Apoptotic Cell Death in the Developing Chick Eye J. Neurosci., February 15, 2001; 21(4): 1292 - 1301. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Tavares, T Tsukui, and J. Izpisua Belmonte Evidence that members of the Cut/Cux/CDP family may be involved in AER positioning and polarizing activity during chick limb development Development, January 12, 2000; 127(23): 5133 - 5144. [Abstract] [PDF]
|
|
|
|
|
|
D. Ellies, V Church, P Francis-West, and A Lumsden The WNT antagonist cSFRP2 modulates programmed cell death in the developing hindbrain Development, January 12, 2000; 127(24): 5285 - 5295. [Abstract] [PDF]
|
|
|
|
|
|
C Vesque, S Ellis, A Lee, M Szabo, P Thomas, R Beddington, and M Placzek Development of chick axial mesoderm: specification of prechordal mesoderm by anterior endoderm-derived TGFbeta family signalling Development, January 7, 2000; 127(13): 2795 - 2809. [Abstract] [PDF]
|
|
|
|
|
|
C Hartmann and C. Tabin Dual roles of Wnt signaling during chondrogenesis in the chicken limb Development, January 7, 2000; 127(14): 3141 - 3159. [Abstract] [PDF]
|
|
|
|
|
|
A Sukegawa, T Narita, T Kameda, K Saitoh, T Nohno, H Iba, S Yasugi, and K Fukuda The concentric structure of the developing gut is regulated by Sonic hedgehog derived from endodermal epithelium Development, January 5, 2000; 127(9): 1971 - 1980. [Abstract] [PDF]
|
|
|
|
|
|
G Drossopoulou, K. Lewis, J. Sanz-Ezquerro, N Nikbakht, A. McMahon, C Hofmann, and C Tickle A model for anteroposterior patterning of the vertebrate limb based on sequential long- and short-range Shh signalling and Bmp signalling Development, January 4, 2000; 127(7): 1337 - 1348. [Abstract] [PDF]
|
|
|
|
|
|
Y Zhang, Z Zhang, X Zhao, X Yu, Y Hu, B Geronimo, S. Fromm, and Y. Chen A new function of BMP4: dual role for BMP4 in regulation of Sonic hedgehog expression in the mouse tooth germ Development, January 4, 2000; 127(7): 1431 - 1443. [Abstract] [PDF]
|
|
|
|
|
|
S. Yi, A Daluiski, R Pederson, V Rosen, and K. Lyons The type I BMP receptor BMPRIB is required for chondrogenesis in the mouse limb Development, January 2, 2000; 127(3): 621 - 630. [Abstract] [PDF]
|
|
|
|
|
|
L. Gerlach, M. Hutson, J. Germiller, D Nguyen-Luu, J. Victor, and K. Barald Addition of the BMP4 antagonist, noggin, disrupts avian inner ear development Development, January 1, 2000; 127(1): 45 - 54. [Abstract] [PDF]
|
|
|
|
|
|
L. C. Heller, Y. Li, K. L. Abrams, and M. B. Rogers Transcriptional Regulation of the Bmp2 Gene. RETINOIC ACID INDUCTION IN F9 EMBRYONAL CARCINOMA CELLS AND SACCHAROMYCES CEREVISIAE J. Biol. Chem., January 15, 1999; 274(3): 1394 - 1400. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. C. Murtaugh, J. H. Chyung, and A. B. Lassar Sonic hedgehog promotes somitic chondrogenesis by altering the cellular response to BMP signaling Genes & Dev., January 15, 1999; 13(2): 225 - 237. [Abstract] [Full Text]
|
|
|
|
|
|
R Merino, J Rodriguez-Leon, D Macias, Y Ganan, A. Economides, and J. Hurle The BMP antagonist Gremlin regulates outgrowth, chondrogenesis and programmed cell death in the developing limb Development, January 12, 1999; 126(23): 5515 - 5522. [Abstract] [PDF]
|
|
|
|
|
|
K. McCabe, E. Gunther, and T. Reh The development of the pattern of retinal ganglion cells in the chick retina: mechanisms that control differentiation Development, January 12, 1999; 126(24): 5713 - 5724. [Abstract] [PDF]
|
|
|
|
|
|
L Lettice, J Hecksher-Sorensen, and R. Hill The dominant hemimelia mutation uncouples epithelial-mesenchymal interactions and disrupts anterior mesenchyme formation in mouse hindlimbs Development, January 11, 1999; 126(21): 4729 - 4736. [Abstract] [PDF]
|
|
|
|
|
|
J. Charrier, M. Teillet, F Lapointe, and N. Le Douarin Defining subregions of Hensen's node essential for caudalward movement, midline development and cell survival Development, January 11, 1999; 126(21): 4771 - 4783. [Abstract] [PDF]
|
|
|
|
|
|
M Scaal, A Bonafede, V Dathe, M Sachs, G Cann, B Christ, and B Brand-Saberi SF/HGF is a mediator between limb patterning and muscle development Development, January 11, 1999; 126(21): 4885 - 4893. [Abstract] [PDF]
|
|
|
|
|
|
T Roeser, S Stein, and M Kessel Nuclear beta-catenin and the development of bilateral symmetry in normal and LiCl-exposed chick embryos Development, January 7, 1999; 126(13): 2955 - 2965. [Abstract] [PDF]
|
|
|
|
|
|
K. Lewis, G Drossopoulou, I. Paton, D. Morrice, K. Robertson, D. Burt, P. Ingham, and C Tickle Expression of ptc and gli genes in talpid3 suggests bifurcation in Shh pathway Development, January 6, 1999; 126(11): 2397 - 2407. [Abstract] [PDF]
|
|
|
|
|
|
K Hashimoto, Y Yokouchi, M Yamamoto, and A Kuroiwa Distinct signaling molecules control Hoxa-11 and Hoxa-13 expression in the muscle precursor and mesenchyme of the chick limb bud Development, January 6, 1999; 126(12): 2771 - 2783. [Abstract] [PDF]
|
|
|
|
|
|
T Obara-Ishihara, J Kuhlman, L Niswander, and D Herzlinger The surface ectoderm is essential for nephric duct formation in intermediate mesoderm Development, January 3, 1999; 126(6): 1103 - 1108. [Abstract] [PDF]
|
|
|
|
|
|
E Coucouvanis and G. Martin BMP signaling plays a role in visceral endoderm differentiation and cavitation in the early mouse embryo Development, January 2, 1999; 126(3): 535 - 546. [Abstract] [PDF]
|
|
|
|
|
|
S Pizette and L Niswander BMPs negatively regulate structure and function of the limb apical ectodermal ridge Development, January 2, 1999; 126(5): 883 - 894. [Abstract] [PDF]
|
|
|
|
|
|
E Pera, S Stein, and M Kessel Ectodermal patterning in the avian embryo: epidermis versus neural plate Development, January 1, 1999; 126(1): 63 - 73. [Abstract] [PDF]
|
|
|
|
|
|
A. Tucker, A Al Khamis, C. Ferguson, I Bach, M. Rosenfeld, and P. Sharpe Conserved regulation of mesenchymal gene expression by Fgf-8 in face and limb development Development, January 1, 1999; 126(2): 221 - 228. [Abstract] [PDF]
|
|
|
|
|
|
I Munoz-Sanjuan, B. Simandl, J. Fallon, and J Nathans Expression of chicken fibroblast growth factor homologous factor (FHF)-1 and of differentially spliced isoforms of FHF-2 during development and involvement of FHF-2 in chicken limb development Development, January 1, 1999; 126(2): 409 - 421. [Abstract] [PDF]
|
|
|
|
 |
|
 H. Li, P. M. Bartold, C. Z. Zhang, R. W. Clarkson, W. G. Young, and M. J. Waters Growth Hormone and Insulin-Like Growth Factor I Induce Bone Morphogenetic Proteins 2 and 4: A Mediator Role in Bone and Tooth Formation? Endocrinology, September 1, 1998; 139(9): 3855 - 3862. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Zhang, M. F. Mehler, Q. Song, and J. A. Kessler Development of Bone Morphogenetic Protein Receptors in the Nervous System and Possible Roles in Regulating trkC Expression J. Neurosci., May 1, 1998; 18(9): 3314 - 3326. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Enomoto-Iwamoto, M. Iwamoto, Y. Mukudai, Y. Kawakami, T. Nohno, Y. Higuchi, S. Takemoto, H. Ohuchi, S. Noji, and K. Kurisu Bone Morphogenetic Protein Signaling Is Required for Maintenance of Differentiated Phenotype, Control of Proliferation, and Hypertrophy in Chondrocytes J. Cell Biol., January 26, 1998; 140(2): 409 - 418. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y Watanabe, D Duprez, A. Monsoro-Burq, C Vincent, and N. Le Douarin Two domains in vertebral development: antagonistic regulation by SHH and BMP4 proteins Development, January 7, 1998; 125(14): 2631 - 2639. [Abstract] [PDF]
|
|
|
|
|
|
H. Kim, D. Rice, P. Kettunen, and I Thesleff FGF-, BMP- and Shh-mediated signalling pathways in the regulation of cranial suture morphogenesis and calvarial bone development Development, January 4, 1998; 125(7): 1241 - 1251. [Abstract] [PDF]
|
|
|
|
|
|
M Yamamoto, Y Gotoh, K Tamura, M Tanaka, A Kawakami, H Ide, and A Kuroiwa Coordinated expression of Hoxa-11 and Hoxa-13 during limb muscle patterning Development, January 4, 1998; 125(7): 1325 - 1335. [Abstract] [PDF]
|
|
|
|
|
|
J Ericson, S Norlin, T. Jessell, and T Edlund Integrated FGF and BMP signaling controls the progression of progenitor cell differentiation and the emergence of pattern in the embryonic anterior pituitary Development, January 3, 1998; 125(6): 1005 - 1015. [Abstract] [PDF]
|
|
|
|
|
|
C Hayes, J. Brown, M. Lyon, and G. Morriss-Kay Sonic hedgehog is not required for polarising activity in the Doublefoot mutant mouse limb bud Development, January 2, 1998; 125(3): 351 - 357. [Abstract] [PDF]
|
|
|
|
|
|
Y. Tanaka, I. Naruse, T. Maekawa, H. Masuya, T. Shiroishi, and S. Ishii Abnormal skeletal patterning in embryos lacking a single Cbp allele: A partial similarity with Rubinstein-Taybi syndrome PNAS, September 16, 1997; 94(19): 10215 - 10220. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Zou, R. Wieser, J. Massague, and L. Niswander Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage Genes & Dev., September 1, 1997; 11(17): 2191 - 2203. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S P Oh and E Li The signaling pathway mediated by the type IIB activin receptor controls axial patterning and lateral asymmetry in the mouse. Genes & Dev., July 15, 1997; 11(14): 1812 - 1826. [Abstract] [PDF]
|
|
|
|
|
|
L. Rifas, D. A. Towler, and L. V. Avioli Gestational exposure to ethanol suppresses msx2 expression in developing mouse embryos PNAS, July 8, 1997; 94(14): 7549 - 7554. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Stratford, K Kostakopoulou, and M Maden Hoxb-8 has a role in establishing early anterior-posterior polarity in chick forelimb but not hindlimb Development, January 11, 1997; 124(21): 4225 - 4234. [Abstract] [PDF]
|
|
|
|
|
|
Y Yang, G Drossopoulou, P. Chuang, D Duprez, E Marti, D Bumcrot, N Vargesson, J Clarke, L Niswander, A McMahon, et al. Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposterior polarity in the chick limb Development, January 11, 1997; 124(21): 4393 - 4404. [Abstract] [PDF]
|
|
|
|
|
|
S Dietrich, F. Schubert, and A Lumsden Control of dorsoventral pattern in the chick paraxial mesoderm Development, January 10, 1997; 124(19): 3895 - 3908. [Abstract] [PDF]
|
|
|
|
|
|
