spacer gif spacer gif spacer gif spacer gif ARCHIVE ANNOUNCEMENT! spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ang, S. L.
Right arrow Articles by Rossant, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ang, S. L.
Right arrow Articles by Rossant, J.

Development, Vol 120, Issue 10 2979-2989, Copyright © 1994 by Company of Biologists

JOURNAL ARTICLES

Positive and negative signals from mesoderm regulate the expression of mouse Otx2 in ectoderm explants

SL Ang, RA Conlon, O Jin and J Rossant
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada.

Otx2, a mouse homolog of the Drosophila orthodenticle gene, is first widely expressed in the epiblast but becomes progressively restricted to the anterior third of the embryo by the headfold stage. This progressive restriction correlates with the anterior migration of mesoderm in the embryo, suggesting that interactions with mesoderm may be involved in setting up the anterior domain of Otx2 expression in vivo. Using explant-recombination assays, we have obtained evidence that a positive signal from anterior mesendoderm is required to stabilize expression of Otx2 in vivo, whereas a negative signal from the later-forming posterior mesendoderm represses Otx2 expression in the posterior part of the embryo. We have also found that exogenous retinoic acid can mimic the effect of this negative signal and reduces the anterior domain of Otx2 expression.


This article has been cited by other articles:


Home page
 Hum Mol GenetHome page
N. Warr, N. Powles-Glover, A. Chappell, J. Robson, D. Norris, and R. M. Arkell
Zic2-associated holoprosencephaly is caused by a transient defect in the organizer region during gastrulation
Hum. Mol. Genet., October 1, 2008; 17(19): 2986 - 2996.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. Beckers, L. Alten, C. Viebahn, P. Andre, and A. Gossler
The mouse homeobox gene Noto regulates node morphogenesis, notochordal ciliogenesis, and left right patterning
PNAS, October 2, 2007; 104(40): 15765 - 15770.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S.-L. Ang
Transcriptional control of midbrain dopaminergic neuron development
Development, September 15, 2006; 133(18): 3499 - 3506.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. Chazaud and J. Rossant
Disruption of early proximodistal patterning and AVE formation in Apc mutants
Development, September 1, 2006; 133(17): 3379 - 3387.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
G. S. Daftary and H. S. Taylor
Endocrine Regulation of HOX Genes
Endocr. Rev., June 1, 2006; 27(4): 331 - 355.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S. T. Waters and M. Lewandoski
A threshold requirement for Gbx2 levels in hindbrain development.
Development, May 1, 2006; 133(10): 1991 - 2000.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
A. P. Jadhav, H. A. Mason, and C. L. Cepko
Notch 1 inhibits photoreceptor production in the developing mammalian retina
Development, March 1, 2006; 133(5): 913 - 923.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
D. Stickens, B. M. Zak, N. Rougier, J. D. Esko, and Z. Werb
Mice deficient in Ext2 lack heparan sulfate and develop exostoses
Development, November 15, 2005; 132(22): 5055 - 5068.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
N. Nishioka, S. Nagano, R. Nakayama, H. Kiyonari, T. Ijiri, K. Taniguchi, W. Shawlot, Y. Hayashizaki, H. Westphal, R. R. Behringer, et al.
Ssdp1 regulates head morphogenesis of mouse embryos by activating the Lim1-Ldb1 complex
Development, June 1, 2005; 132(11): 2535 - 2546.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
N. Gotoh, K. Manova, S. Tanaka, M. Murohashi, Y. Hadari, A. Lee, Y. Hamada, T. Hiroe, M. Ito, T. Kurihara, et al.
The Docking Protein FRS2{alpha} Is an Essential Component of Multiple Fibroblast Growth Factor Responses during Early Mouse Development
Mol. Cell. Biol., May 15, 2005; 25(10): 4105 - 4116.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. Y. H. Li, Z. Lao, and A. L. Joyner
New regulatory interactions and cellular responses in the isthmic organizer region revealed by altering Gbx2 expression
Development, April 15, 2005; 132(8): 1971 - 1981.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
T. Kunath, D. Arnaud, G. D. Uy, I. Okamoto, C. Chureau, Y. Yamanaka, E. Heard, R. L. Gardner, P. Avner, and J. Rossant
Imprinted X-inactivation in extra-embryonic endoderm cell lines from mouse blastocysts
Development, April 1, 2005; 132(7): 1649 - 1661.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
R. Kemler, A. Hierholzer, B. Kanzler, S. Kuppig, K. Hansen, M. M. Taketo, W. N. de Vries, B. B. Knowles, and D. Solter
Stabilization of {beta}-catenin in the mouse zygote leads to premature epithelial-mesenchymal transition in the epiblast
Development, December 1, 2004; 131(23): 5817 - 5824.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
D. Kurokawa, H. Kiyonari, R. Nakayama, C. Kimura-Yoshida, I. Matsuo, and S. Aizawa
Regulation of Otx2 expression and its functions in mouse forebrain and midbrain
Development, July 15, 2004; 131(14): 3319 - 3331.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. Kimura-Yoshida, K. Kitajima, I. Oda-Ishii, E Tian, M. Suzuki, M. Yamamoto, T. Suzuki, M. Kobayashi, S. Aizawa, and I. Matsuo
Characterization of the pufferfish Otx2 cis-regulators reveals evolutionarily conserved genetic mechanisms for vertebrate head specification
Development, January 1, 2004; 131(1): 57 - 71.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
M. Lebel, P. Agarwal, C. W. Cheng, M. G. Kabir, T. Y. Chan, V. Thanabalasingham, X. Zhang, D. R. Cohen, M. Husain, S. H. Cheng, et al.
The Iroquois Homeobox Gene Irx2 Is Not Essential for Normal Development of the Heart and Midbrain-Hindbrain Boundary in Mice
Mol. Cell. Biol., November 15, 2003; 23(22): 8216 - 8225.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
I. del Barco Barrantes, G. Davidson, H.-J. Grone, H. Westphal, and C. Niehrs
Dkk1 and noggin cooperate in mammalian head induction
Genes & Dev., September 15, 2003; 17(18): 2239 - 2244.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
S. D. Vincent, N. R. Dunn, S. Hayashi, D. P. Norris, and E. J. Robertson
Cell fate decisions within the mouse organizer are governed by graded Nodal signals
Genes & Dev., July 1, 2003; 17(13): 1646 - 1662.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
W. Chen, Y. Liang, W. Deng, K. Shimizu, A. M. Ashique, E. Li, and Y.-P. Li
The zinc-finger protein CNBP is required for forebrain formation in the mouse
Development, April 1, 2003; 130(7): 1367 - 1379.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
T. Hide, J. Hatakeyama, C. Kimura-Yoshida, E Tian, N. Takeda, Y. Ushio, T. Shiroishi, S. Aizawa, and I. Matsuo
Genetic modifiers of otocephalic phenotypes in Otx2 heterozygous mutant mice
Development, March 11, 2003; 129(18): 4347 - 4357.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
D. P. Norris, J. Brennan, E. K. Bikoff, and E. J. Robertson
The Foxh1-dependent autoregulatory enhancer controls the level of Nodal signals in the mouse embryo
Development, March 9, 2003; 129(14): 3455 - 3468.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. Mukhopadhyay, A. Teufel, T. Yamashita, A. D. Agulnick, L. Chen, K. M. Downs, A. Schindler, A. Grinberg, S.-P. Huang, D. Dorward, et al.
Functional ablation of the mouse Ldb1 gene results in severe patterning defects during gastrulation
Development, February 1, 2003; 130(3): 495 - 505.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
D. Kobayashi, M. Kobayashi, K. Matsumoto, T. Ogura, M. Nakafuku, and K. Shimamura
Early subdivisions in the neural plate define distinct competence for inductive signals
Development, January 1, 2002; 129(1): 83 - 93.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. Y. H. Li and A. L. Joyner
Otx2 and Gbx2 are required for refinement and not induction of mid-hindbrain gene expression
Development, December 15, 2001; 128(24): 4979 - 4991.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. E. Erter, T. P. Wilm, N. Basler, C. V. E. Wright, and L. Solnica-Krezel
Wnt8 is required in lateral mesendodermal precursors for neural posteriorization in vivo
Development, September 15, 2001; 128(18): 3571 - 3583.
[Abstract] [Full Text] [PDF]

Home page
 Integr. Comp. Biol.Home page
V. F. Hinman and B. M. Degnan
Homeobox Genes, Retinoic Acid and the Development and Evolution of Dual Body Plans in the Ascidian Herdmania curvata
Integr. Comp. Biol., June 1, 2001; 41(3): 664 - 675.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
M. Yamamoto, C. Meno, Y. Sakai, H. Shiratori, K. Mochida, Y. Ikawa, Y. Saijoh, and H. Hamada
The transcription factor FoxH1 (FAST) mediates Nodal signaling during anterior-posterior patterning and node formation in the mouse
Genes & Dev., May 15, 2001; 15(10): 1242 - 1256.
[Abstract] [Full Text]

Home page
 DevelopmentHome page
M. Dyer, S. Farrington, D Mohn, J. Munday, and M. Baron
Indian hedgehog activates hematopoiesis and vasculogenesis and can respecify prospective neurectodermal cell fate in the mouse embryo
Development, January 5, 2001; 128(10): 1717 - 1730.
[Abstract] [PDF]

Home page
 DevelopmentHome page
A Perea-Gomez, K. Lawson, M Rhinn, L Zakin, P Brulet, S Mazan, and S. Ang
Otx2 is required for visceral endoderm movement and for the restriction of posterior signals in the epiblast of the mouse embryo
Development, January 3, 2001; 128(5): 753 - 765.
[Abstract] [PDF]

Home page
 DevelopmentHome page
S Withington, R Beddington, and J Cooke
Foregut endoderm is required at head process stages for anteriormost neural patterning in chick
Development, January 2, 2001; 128(3): 309 - 320.
[Abstract] [PDF]

Home page
 DevelopmentHome page
A. Foley, I Skromne, and C. Stern
Reconciling different models of forebrain induction and patterning: a dual role for the hypoblast
Development, January 9, 2000; 127(17): 3839 - 3854.
[Abstract] [PDF]

Home page
 DevelopmentHome page
S Kitajima, A Takagi, T Inoue, and Y Saga
MesP1 and MesP2 are essential for the development of cardiac mesoderm
Development, January 8, 2000; 127(15): 3215 - 3226.
[Abstract] [PDF]

Home page
 DevelopmentHome page
K. Tremblay, P. Hoodless, E. Bikoff, and E. Robertson
Formation of the definitive endoderm in mouse is a Smad2-dependent process
Development, January 7, 2000; 127(14): 3079 - 3090.
[Abstract] [PDF]

Home page
 DevelopmentHome page
J. Martinez Barbera, M Clements, P Thomas, T Rodriguez, D Meloy, D Kioussis, and R. Beddington
The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation
Development, January 6, 2000; 127(11): 2433 - 2445.
[Abstract] [PDF]

Home page
 DevelopmentHome page
A Camus, B. Davidson, S Billiards, P Khoo, J. Rivera-Perez, M Wakamiya, R. Behringer, and P. Tam
The morphogenetic role of midline mesendoderm and ectoderm in the development of the forebrain and the midbrain of the mouse embryo
Development, January 5, 2000; 127(9): 1799 - 1813.
[Abstract] [PDF]

Home page
 DevelopmentHome page
J. Wells and D. Melton
Early mouse endoderm is patterned by soluble factors from adjacent germ layers
Development, January 4, 2000; 127(8): 1563 - 1572.
[Abstract] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T. Yamashita, R. Wada, T. Sasaki, C. Deng, U. Bierfreund, K. Sandhoff, and R. L. Proia
A vital role for glycosphingolipid synthesis during development and differentiation
PNAS, August 3, 1999; 96(16): 9142 - 9147.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
X. Sun, E. N. Meyers, M. Lewandoski, and G. R. Martin
Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo
Genes & Dev., July 15, 1999; 13(14): 1834 - 1846.
[Abstract] [Full Text]

Home page
 NeuroscientistHome page
E. Boncinelli
Review : Otx and Emx Homeobox Genes in Brain Development
Neuroscientist, May 1, 1999; 5(3): 164 - 172.
[Abstract] [PDF]

Home page
 DevelopmentHome page
W Shawlot, M Wakamiya, K. Kwan, A Kania, T. Jessell, and R. Behringer
Lim1 is required in both primitive streak-derived tissues and visceral endoderm for head formation in the mouse
Development, January 11, 1999; 126(22): 4925 - 4932.
[Abstract] [PDF]

Home page
 DevelopmentHome page
P. Franco, A. Paganelli, S. Lopez, and A. Carrasco
Functional association of retinoic acid and hedgehog signaling in Xenopus primary neurogenesis
Development, January 10, 1999; 126(19): 4257 - 4265.
[Abstract] [PDF]

Home page
 DevelopmentHome page
A Perea-Gomez, W Shawlot, H Sasaki, R. Behringer, and S Ang
HNF3beta and Lim1 interact in the visceral endoderm to regulate primitive streak formation and anterior-posterior polarity in the mouse embryo
Development, January 10, 1999; 126(20): 4499 - 4511.
[Abstract] [PDF]

Home page
 DevelopmentHome page
A. Rowan, C. Stern, and K. Storey
Axial mesendoderm refines rostrocaudal pattern in the chick nervous system
Development, January 7, 1999; 126(13): 2921 - 2934.
[Abstract] [PDF]

Home page
 DevelopmentHome page
H Morsli, F Tuorto, D Choo, M. Postiglione, A Simeone, and D. Wu
Otx1 and Otx2 activities are required for the normal development of the mouse inner ear
Development, January 6, 1999; 126(11): 2335 - 2343.
[Abstract] [PDF]

Home page
 DevelopmentHome page
M Hidalgo-Sanchez, A Simeone, and R. Alvarado-Mallart
Fgf8 and Gbx2 induction concomitant with Otx2 repression is correlated with midbrain-hindbrain fate of caudal prosencephalon
Development, January 6, 1999; 126(14): 3191 - 3203.
[Abstract] [PDF]

Home page
 DevelopmentHome page
D Acampora, V Avantaggiato, F Tuorto, P Barone, M Perera, D Choo, D Wu, G Corte, and A Simeone
Differential transcriptional control as the major molecular event in generating Otx1-/- and Otx2-/- divergent phenotypes
Development, January 4, 1999; 126(7): 1417 - 1426.
[Abstract] [PDF]

Home page
 DevelopmentHome page
S Martinez, P. Crossley, I Cobos, J. Rubenstein, and G. Martin
FGF8 induces formation of an ectopic isthmic organizer and isthmocerebellar development via a repressive effect on Otx2 expression
Development, January 3, 1999; 126(6): 1189 - 1200.
[Abstract] [PDF]

Home page
 DevelopmentHome page
Y Suda, J Nakabayashi, I Matsuo, and S Aizawa
Functional equivalency between Otx2 and Otx1 in development of the rostral head
Development, January 2, 1999; 126(4): 743 - 757.
[Abstract] [PDF]

Home page
 DevelopmentHome page
H Knoetgen, C Viebahn, and M Kessel
Head induction in the chick by primitive endoderm of mammalian, but not avian origin
Development, January 2, 1999; 126(4): 815 - 825.
[Abstract] [PDF]

Home page
 DevelopmentHome page
R. Warga and C Nusslein-Volhard
Origin and development of the zebrafish endoderm
Development, January 2, 1999; 126(4): 827 - 838.
[Abstract] [PDF]

Home page
 J. Neurosci.Home page
L. Yang, H. Zhang, G. Hu, H. Wang, C. Abate-Shen, and M. M. Shen
An Early Phase of Embryonic Dlx5 Expression Defines the Rostral Boundary of the Neural Plate
J. Neurosci., October 15, 1998; 18(20): 8322 - 8330.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
W. Shawlot, J. M. Deng, and R. R. Behringer
Expression of the mouse cerberus-related gene, Cerr1, suggests a role in anterior neural induction and somitogenesis
PNAS, May 26, 1998; 95(11): 6198 - 6203.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Guazzi, M. L. Pintonello, A. Vigano, and E. Boncinelli
Regulatory Interactions between the Human HOXB1, HOXB2, and HOXB3 Proteins and the Upstream Sequence of the Otx2 Gene in Embryonal Carcinoma Cells
J. Biol. Chem., May 1, 1998; 273(18): 11092 - 11099.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M Belaoussoff, S. Farrington, and M. Baron
Hematopoietic induction and respecification of A-P identity by visceral endoderm signaling in the mouse embryo
Development, January 12, 1998; 125(24): 5009 - 5018.
[Abstract] [PDF]

Home page
 DevelopmentHome page
D Acampora, V Avantaggiato, F Tuorto, P Briata, G Corte, and A Simeone
Visceral endoderm-restricted translation of Otx1 mediates recovery of Otx2 requirements for specification of anterior neural plate and normal gastrulation
Development, January 12, 1998; 125(24): 5091 - 5104.
[Abstract] [PDF]

Home page
 DevelopmentHome page
Y Grinblat, J Gamse, M Patel, and H Sive
Determination of the zebrafish forebrain: induction and patterning
Development, January 11, 1998; 125(22): 4403 - 4416.
[Abstract] [PDF]

Home page
 DevelopmentHome page
C. Zygar, T. Cook, and R. Grainger
Gene activation during early stages of lens induction in Xenopus
Development, January 9, 1998; 125(17): 3509 - 3519.
[Abstract] [PDF]

Home page
 DevelopmentHome page
M Hallonet, T Hollemann, R Wehr, N. Jenkins, N. Copeland, T Pieler, and P Gruss
Vax1 is a novel homeobox-containing gene expressed in the developing anterior ventral forebrain
Development, January 7, 1998; 125(14): 2599 - 2610.
[Abstract] [PDF]

Home page
 DevelopmentHome page
S Koshida, M Shinya, T Mizuno, A Kuroiwa, and H Takeda
Initial anteroposterior pattern of the zebrafish central nervous system is determined by differential competence of the epiblast
Development, January 5, 1998; 125(10): 1957 - 1966.
[Abstract] [PDF]

Home page
 DevelopmentHome page
M Rhinn, A Dierich, W Shawlot, R. Behringer, M Le Meur, and S. Ang
Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification
Development, January 3, 1998; 125(5): 845 - 856.
[Abstract] [PDF]

Home page
 DevelopmentHome page
M Studer, A Gavalas, H Marshall, L Ariza-McNaughton, F. Rijli, P Chambon, and R Krumlauf
Genetic interactions between Hoxa1 and Hoxb1 reveal new roles in regulation of early hindbrain patterning
Development, January 3, 1998; 125(6): 1025 - 1036.
[Abstract] [PDF]

Home page
 DevelopmentHome page
P. Thomas, A Brown, and R. Beddington
Hex: a homeobox gene revealing peri-implantation asymmetry in the mouse embryo and an early transient marker of endothelial cell precursors
Development, January 1, 1998; 125(1): 85 - 94.
[Abstract] [PDF]

Home page
 DevelopmentHome page
C Kimura, N Takeda, M Suzuki, M Oshimura, S Aizawa, and I Matsuo
Cis-acting elements conserved between mouse and pufferfish Otx2 genes govern the expression in mesencephalic neural crest cells
Development, January 10, 1997; 124(20): 3929 - 3941.
[Abstract] [PDF]

Home page
 DevelopmentHome page
K. Wassarman, M Lewandoski, K Campbell, A. Joyner, J. Rubenstein, S Martinez, and G. Martin
Specification of the anterior hindbrain and