|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 120, Issue 2 453-462, Copyright © 1994 by Company of Biologists
JOURNAL ARTICLES |
RA Cornell and D Kimelman
Department of Biochemistry SJ-70, School of Medicine, University of Washington, Seattle 98195.
The early patterning of mesoderm in the Xenopus embryo requires signals from several intercellular factors, including mesoderm-inducing agents that belong to the fibroblast growth factor (FGF) and TGF-beta families. In animal hemisphere explants (animal caps), basic FGF and the TGF-beta family member activin are capable of converting pre-ectodermal cells to a mesodermal fate, although activin is much more effective at inducing dorsal and anterior mesoderm than is basic FGF. Using a dominant-negative form of the Xenopus type 1 FGF receptor, we show that an FGF signal is required for the full induction of mesoderm by activin. Animal caps isolated from embryos that have been injected with the truncated FGF receptor and cultured with activin do not extend and the induction of some genes, including cardiac actin and Xbra, is greatly diminished, while the induction of other genes, including the head organizer-specific genes gsc and Xlim-1, is less sensitive. These results are consistent with the phenotype of the truncated FGF receptor-injected embryo and imply that the activin induction of mesoderm depends on FGF, with some genes requiring a higher level of FGF signaling than others.
This article has been cited by other articles:
|
|
 |
|
  M. J. Geske, X. Zhang, K. K. Patel, D. M. Ornitz, and T. S. Stappenbeck Fgf9 signaling regulates small intestinal elongation and mesenchymal development Development, September 1, 2008; 135(17): 2959 - 2968. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Zhang, J. Li, Z. Tan, C. Wang, T. Liu, L. Chen, J. Yong, W. Jiang, X. Sun, L. Du, et al. Short-term BMP-4 treatment initiates mesoderm induction in human embryonic stem cells Blood, February 15, 2008; 111(4): 1933 - 1941. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Walmsley, D. Cleaver, and R. Patient Fibroblast growth factor controls the timing of Scl, Lmo2, and Runx1 expression during embryonic blood development Blood, February 1, 2008; 111(3): 1157 - 1166. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Cordenonsi, M. Montagner, M. Adorno, L. Zacchigna, G. Martello, A. Mamidi, S. Soligo, S. Dupont, and S. Piccolo Integration of TGF-{beta} and Ras/MAPK Signaling Through p53 Phosphorylation Science, February 9, 2007; 315(5813): 840 - 843. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. K. Ko and E. P. Kay Regulatory Role of FGF-2 on Type I Collagen Expression during Endothelial Mesenchymal Transformation Invest. Ophthalmol. Vis. Sci., December 1, 2005; 46(12): 4495 - 4503. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Vallier, M. Alexander, and R. A. Pedersen Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells J. Cell Sci., October 1, 2005; 118(19): 4495 - 4509. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. T. Bottcher and C. Niehrs Fibroblast Growth Factor Signaling during Early Vertebrate Development Endocr. Rev., February 1, 2005; 26(1): 63 - 77. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Bertocchini, I. Skromne, L. Wolpert, and C. D. Stern Determination of embryonic polarity in a regulative system: evidence for endogenous inhibitors acting sequentially during primitive streak formation in the chick embryo Development, July 15, 2004; 131(14): 3381 - 3390. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. P. Myers, L. B. Corson, J. Rossant, and J. C. Baker Characterization of Mouse Rsk4 as an Inhibitor of Fibroblast Growth Factor-RAS-Extracellular Signal-Regulated Kinase Signaling Mol. Cell. Biol., May 15, 2004; 24(10): 4255 - 4266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Mathieu, K. Griffin, P. Herbomel, T. Dickmeis, U. Strahle, D. Kimelman, F. M. Rosa, and N. Peyrieras Nodal and Fgf pathways interact through a positive regulatory loop and synergize to maintain mesodermal cell populations Development, February 1, 2004; 131(3): 629 - 641. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Zhang, H. M. El-Hodiri, H.-F. Ma, X. Zhang, M. Servetnick, T. G. Wensel, and M. Jamrich Targeted expression of the dominant-negative FGFR4a in the eye using Xrx1A regulatory sequences interferes with normal retinal development Development, September 1, 2003; 130(17): 4177 - 4186. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.-H. Monsoro-Burq, R. B. Fletcher, and R. M. Harland Neural crest induction by paraxial mesoderm in Xenopus embryos requires FGF signals Development, July 15, 2003; 130(14): 3111 - 3124. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Fisher, H. V. Isaacs, and M. E. Pownall eFGF is required for activation of XmyoD expression in the myogenic cell lineage of Xenopus laevis Development, March 5, 2003; 129(6): 1307 - 1315. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. L. Nutt, K. S. Dingwell, C. E. Holt, and E. Amaya Xenopus Sprouty2 inhibits FGF-mediated gastrulation movements but does not affect mesoderm induction and patterning Genes & Dev., May 1, 2001; 15(9): 1152 - 1166. [Abstract] [Full Text]
|
|
|
|
|
|
R Carballada, H Yasuo, and P Lemaire Phosphatidylinositol-3 kinase acts in parallel to the ERK MAP kinase in the FGF pathway during Xenopus mesoderm induction Development, January 1, 2001; 128(1): 35 - 44. [Abstract] [PDF]
|
|
|
|
|
|
H Weber, C. Symes, M. Walmsley, A. Rodaway, and R. Patient A role for GATA5 in Xenopus endoderm specification Development, January 10, 2000; 127(20): 4345 - 4360. [Abstract] [PDF]
|
|
|
|
|
|
S Faure, M. Lee, T Keller, P ten Dijke, and M Whitman Endogenous patterns of TGFbeta superfamily signaling during early Xenopus development Development, January 7, 2000; 127(13): 2917 - 2931. [Abstract] [PDF]
|
|
|
|
|
|
P Faloon, E Arentson, A Kazarov, C. Deng, C Porcher, S Orkin, and K Choi Basic fibroblast growth factor positively regulates hematopoietic development Development, January 5, 2000; 127(9): 1931 - 1941. [Abstract] [PDF]
|
|
|
|
|
|
M. A. Torres, H. Eldar-Finkelman, E. G. Krebs, and R. T. Moon Regulation of Ribosomal S6 Protein Kinase-p90rsk, Glycogen Synthase Kinase 3, and beta -Catenin in Early Xenopus Development Mol. Cell. Biol., February 1, 1999; 19(2): 1427 - 1437. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Nagel and R Winklbauer Establishment of substratum polarity in the blastocoel roof of the Xenopus embryo Development, January 5, 1999; 126(9): 1975 - 1984. [Abstract] [PDF]
|
|
|
|
|
|
B. Sun, S. Bush, L. Collins-Racie, E. LaVallie, E. DiBlasio-Smith, N. Wolfman, J. McCoy, and H. Sive derriere: a TGF-beta family member required for posterior development in Xenopus Development, January 4, 1999; 126(7): 1467 - 1482. [Abstract] [PDF]
|
|
|
|
|
|
B Christen and J. Slack Spatial response to fibroblast growth factor signalling in Xenopus embryos Development, January 1, 1999; 126(1): 119 - 125. [Abstract] [PDF]
|
|
|
|
 |
|
 A. R. Uzgare, J. A. Uzman, H. M. El-Hodiri, and A. K. Sater Mitogen-activated protein kinase and neural specification in Xenopus PNAS, December 8, 1998; 95(25): 14833 - 14838. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P Dvorak, A Hampl, L Jirmanova, J Pacholikova, and M Kusakabe Embryoglycan ectodomains regulate biological activity of FGF-2 to embryonic stem cells J. Cell Sci., January 10, 1998; 111(19): 2945 - 2952. [Abstract] [PDF]
|
|
|
|
|
|
J Zhang and R. Carthew Interactions between Wingless and DFz2 during Drosophila wing development Development, January 8, 1998; 125(16): 3075 - 3085. [Abstract] [PDF]
|
|
|
|
|
|
S Wacker, A Brodbeck, P Lemaire, C Niehrs, and R Winklbauer Patterns and control of cell motility in the Xenopus gastrula Development, January 5, 1998; 125(10): 1931 - 1942. [Abstract] [PDF]
|
|
|
|
|
|
A. Bikfalvi, S. Klein, G. Pintucci, and D. B. Rifkin Biological Roles of Fibroblast Growth Factor-2 Endocr. Rev., February 1, 1997; 18(1): 26 - 45. [Abstract] [Full Text]
|
|
|
|
|
|
A. Bang, N Papalopulu, C Kintner, and M. Goulding Expression of Pax-3 is initiated in the early neural plate by posteriorizing signals produced by the organizer and by posterior non-axial mesoderm Development, January 5, 1997; 124(10): 2075 - 2085. [Abstract] [PDF]
|
|
|
|
|
|
C Pittack, G. Grunwald, and T. Reh Fibroblast growth factors are necessary for neural retina but not pigmented epithelium differentiation in chick embryos Development, January 2, 1997; 124(4): 805 - 816. [Abstract] [PDF]
|
|
|
|
|
|
P Dvorak, J. Flechon, E. Thompson, V Horak, P Adenot, and J. Renard Embryoglycans regulate FGF-2-mediated mesoderm induction in the rabbit embryo J. Cell Sci., January 1, 1997; 110(1): 1 - 10. [Abstract] [PDF]
|
|
|
|
|
|
K. Lustig, K. Kroll, E. Sun, and M. Kirschner Expression cloning of a Xenopus T-related gene (Xombi) involved in mesodermal patterning and blastopore lip formation Development, January 12, 1996; 122(12): 4001 - 4012. [Abstract] [PDF]
|
|
|
|
|
|
F Stennard, G Carnac, and J. Gurdon The Xenopus T-box gene, Antipodean, encodes a vegetally localised maternal mRNA and can trigger mesoderm formation Development, January 12, 1996; 122(12): 4179 - 4188. [Abstract] [PDF]
|
|
|
|
|
|
K. Kroll and E Amaya Transgenic Xenopus embryos from sperm nuclear transplantations reveal FGF signaling requirements during gastrulation Development, January 10, 1996; 122(10): 3173 - 3183. [Abstract] [PDF]
|
|
|
|
|
|
G. Thomsen Xenopus mothers against decapentaplegic is an embryonic ventralizing agent that acts downstream of the BMP-2/4 receptor Development, January 8, 1996; 122(8): 2359 - 2366. [Abstract] [PDF]
|
|
|
|
|
|
J. Schmidt, G von Dassow, and D Kimelman Regulation of dorsal-ventral patterning: the ventralizing effects of the novel Xenopus homeobox gene Vox Development, January 6, 1996; 122(6): 1711 - 1721. [Abstract] [PDF]
|
|
|
|
|
|
C Launay, V Fromentoux, D. Shi, and J. Boucaut A truncated FGF receptor blocks neural induction by endogenous Xenopus inducers Development, January 3, 1996; 122(3): 869 - 880. [Abstract] [PDF]
|
|
|
|
|
|
N Itoh, T Mima, and T Mikawa Loss of fibroblast growth factor receptors is necessary for terminal differentiation of embryonic limb muscle Development, January 1, 1996; 122(1): 291 - 300. [Abstract] [PDF]
|
|
|
|
|
|
C. Jones, M. Kuehn, B. Hogan, J. Smith, and C. Wright Nodal-related signals induce axial mesoderm and dorsalize mesoderm during gastrulation Development, January 11, 1995; 121(11): 3651 - 3662. [Abstract] [PDF]
|
|
|
|
|
|
K Griffin, R Patient, and N Holder Analysis of FGF function in normal and no tail zebrafish embryos reveals separate mechanisms for formation of the trunk and the tail Development, January 9, 1995; 121(9): 2983 - 2994. [Abstract] [PDF]
|
|
|
|
|
|
M Kengaku and H Okamoto bFGF as a possible morphogen for the anteroposterior axis of the central nervous system in Xenopus Development, January 9, 1995; 121(9): 3121 - 3130. [Abstract] [PDF]
|
|
|
|
|
|
R. Cornell, T. Musci, and D Kimelman FGF is a prospective competence factor for early activin-type signals in Xenopus mesoderm induction Development, January 8, 1995; 121(8): 2429 - 2437. [Abstract] [PDF]
|
|
|
|
|
|
D. Kessler and D. Melton Induction of dorsal mesoderm by soluble, mature Vg1 protein Development, January 7, 1995; 121(7): 2155 - 2164. [Abstract] [PDF]
|
|
|
|
|
|
K Kinoshita and M Asashima Effect of activin and lithium on isolated Xenopus animal blastomeres and response alteration at the midblastula transition Development, January 6, 1995; 121(6): 1581 - 1589. [Abstract] [PDF]
|
|
|
|
|
|
E. Robbie, M Peterson, E Amaya, and T. Musci Temporal regulation of the Xenopus FGF receptor in development: a translation inhibitory element in the 3' untranslated region Development, January 6, 1995; 121(6): 1775 - 1785. [Abstract] [PDF]
|
|
|
|
|
|
C LaBonne, B Burke, and M Whitman Role of MAP kinase in mesoderm induction and axial patterning during Xenopus development Development, January 5, 1995; 121(5): 1475 - 1486. [Abstract] [PDF]
|
|
|
|
|
|
S. Pierce and D Kimelman Regulation of Spemann organizer formation by the intracellular kinase Xgsk-3 Development, January 3, 1995; 121(3): 755 - 765. [Abstract] [PDF]
|
|
|
|
|
|
C X Deng, A Wynshaw-Boris, M M Shen, C Daugherty, D M Ornitz, and P Leder Murine FGFR-1 is required for early postimplantation growth and axial organization. Genes & Dev., December 15, 1994; 8(24): 3045 - 3057. [Abstract] [PDF]
|
|
|
|
|
|
D. Kessler and D. Melton Vertebrate embryonic induction: mesodermal and neural patterning Science, October 28, 1994; 266(5185): 596 - 604. [Abstract] [PDF]
|
|
|
|
|
|
K. Itoh and S. Y. Sokol Heparan sulfate proteoglycans are required for mesoderm formation in Xenopus embryos Development, September 1, 1994; 120(9): 2703 - 2711. [Abstract] [PDF]
|
|
|
|
|
|
J. Green, J. Smith, and J. Gerhart Slow emergence of a multithreshold response to activin requires cell-contact-dependent sharpening but not prepattern Development, January 8, 1994; 120(8): 2271 - 2278. [Abstract] [PDF]
|
|
|
|
|
|
C LaBonne and M Whitman Mesoderm induction by activin requires FGF-mediated intracellular signals Development, January 2, 1994; 120(2): 463 - 472. [Abstract] [PDF]
|
|
