|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 120, Issue 8 2287-2296, Copyright © 1994 by Company of Biologists
JOURNAL ARTICLES |
P de Zulueta, E Alexandre, B Jacq and S Kerridge
Laboratoire de Genetique et Physiologie du Developpement, CNRS, Universite d'Aix-Marseille II, France.
Homeotic genes determine the identities of metameres in Drosophila. We have examined functional aspects of the homeotic gene teashirt by ectopically expressing its product under the control of a heat-shock promoter during embryogenesis. Our results confirm that the gene is critical for segmental identity of the larva. Under mild heat-shock conditions, the Teashirt protein induces an almost complete transformation of the labial to prothoracic segmental identity, when expressed before 8 hours of development. Positive autoregulation of the endogenous teashirt gene and the presence of Sex combs reduced protein in the labium explain this homeosis. Patterns in the maxillary and a more anterior head segment are partly replaced with trunk ones. Additional Teashirt protein has no effect on the identity of the trunk segments where the gene is normally expressed; teashirt function is overridden by some homeotic complex acting in the posterior trunk. Strong heat-shock regimes provoke novel defects: ectopic sense organs differentiate in posterior abdominal segments and trunk pattern elements differentiate in the ninth abdominal segment. Teashirt acts in a partially redundant way with certain homeotic complex proteins but co-operates with them for the establishment of specific segment types. We suggest that Teashirt and HOM-C proteins regulate common sets of downstream target genes.
This article has been cited by other articles:
|
|
 |
|
  L. R. Sanders, M. Patel, and J. W. Mahaffey The Drosophila Gap Gene giant Has an Anterior Segment Identity Function Mediated Through disconnected and teashirt Genetics, May 1, 2008; 179(1): 441 - 453. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Coiffier, B. Charroux, and S. Kerridge Common functions of central and posterior Hox genes for the repression of head in the trunk of Drosophila Development, January 15, 2008; 135(2): 291 - 300. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. K. Robertson, D. B. Bowling, J. P. Mahaffey, B. Imiolczyk, and J. W. Mahaffey An interactive network of zinc-finger proteins contributes to regionalization of the Drosophila embryo and establishes the domains of HOM-C protein function Development, June 15, 2004; 131(12): 2781 - 2789. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Manfroid, X. Caubit, S. Kerridge, and L. Fasano Three putative murine Teashirt orthologues specify trunk structures in Drosophila in the same way as the Drosophila teashirt gene Development, March 1, 2004; 131(5): 1065 - 1073. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Singh, M. Kango-Singh, and Y. H. Sun Eye suppression, a novel function of teashirt, requires Wingless signaling Development, March 11, 2003; 129(18): 4271 - 4280. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Erkner, A. Roure, B. Charroux, M. Delaage, N. Holway, N. Core, C. Vola, C. Angelats, F. Pages, L. Fasano, et al. Grunge, related to human Atrophin-like proteins, has multiple functions in Drosophila development Development, January 3, 2002; 129(5): 1119 - 1129. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H Zhang and S. Emmons The novel C. elegans gene sop-3 modulates Wnt signaling to regulate Hox gene expression Development, January 3, 2001; 128(5): 767 - 777. [Abstract] [PDF]
|
|
|
|
 |
|
 V. Hatini, P. Bokor, R. Goto-Mandeville, and S. DiNardo Tissue- and stage-specific modulation of Wingless signaling by the segment polarity gene lines Genes & Dev., June 1, 2000; 14(11): 1364 - 1376. [Abstract] [Full Text]
|
|
|
|
|
|
A Gallet, C Angelats, S Kerridge, and P. Therond Cubitus interruptus-independent transduction of the Hedgehog signal in Drosophila Development, January 12, 2000; 127(24): 5509 - 5522. [Abstract] [PDF]
|
|
|
|
|
|
E. Wiellette, K. Harding, K. Mace, M. Ronshaugen, F. Wang, and W McGinnis spen encodes an RNP motif protein that interacts with Hox pathways to repress the development of head-like sclerites in the Drosophila trunk Development, January 12, 1999; 126(23): 5373 - 5385. [Abstract] [PDF]
|
|
|
|
|
|
Q Ch'ng and C Kenyon egl-27 generates anteroposterior patterns of cell fusion in C. elegans by regulating Hox gene expression and Hox protein function Development, January 8, 1999; 126(15): 3303 - 3312. [Abstract] [PDF]
|
|
|
|
 |
|
 D. Pan and G. M. Rubin Targeted expression of teashirt induces ectopic eyes in Drosophila PNAS, December 22, 1998; 95(26): 15508 - 15512. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Biggin and W McGinnis Regulation of segmentation and segmental identity by Drosophila homeoproteins: the role of DNA binding in functional activity and specificity Development, January 11, 1997; 124(22): 4425 - 4433. [Abstract] [PDF]
|
|
|
|
|
|
G Gellon, K. Harding, N McGinnis, M. Martin, and W McGinnis A genetic screen for modifiers of Deformed homeotic function identifies novel genes required for head development Development, January 9, 1997; 124(17): 3321 - 3331. [Abstract] [PDF]
|
|
|
|
|
|
R Wilk, I Weizman, and B Z Shilo trachealess encodes a bHLH-PAS protein that is an inducer of tracheal cell fates in Drosophila. Genes & Dev., January 1, 1996; 10(1): 93 - 102. [Abstract] [PDF]
|
|
|
|
|
|
A McCormick, N Core, S Kerridge, and M. Scott Homeotic response elements are tightly linked to tissue-specific elements in a transcriptional enhancer of the teashirt gene Development, January 9, 1995; 121(9): 2799 - 2812. [Abstract] [PDF]
|
|
|
|
|
|
K Woo and S. Fraser Order and coherence in the fate map of the zebrafish nervous system Development, January 8, 1995; 121(8): 2595 - 2609. [Abstract] [PDF]
|
|
