|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 121, Issue 12 3935-3945, Copyright © 1995 by Company of Biologists
JOURNAL ARTICLES |
KJ Millen, CC Hui and AL Joyner
Department of Molecular and Medical Genetics, University of Toronto, Canada.
To gain insight into the molecular genetic basis of cerebellar patterning, the expression patterns of many vertebrate homologues of Drosophila segment polarity genes were examined during normal and abnormal cerebellar development, including members of the En, Wnt, Pax, Gli and Dvl gene families. Five of these genes were found to show transient, spatially restricted patterns of expression. Strikingly, expression of En-2, En-1, Wnt-7B and Pax-2 defined eleven similar sagittal domains at 17.5 dpc, reminiscent of the transient sagittal domains of expression of Purkinje cell markers which have been implicated in cerebellar afferent patterning. Postnatally, transient anterior/posterior differences in expression were observed for En-2, En-1, Gli and Wnt-7B dividing the cerebellum into anterior and posterior regions. The expression patterns of these genes were altered in cerebella of En-2 homozygous mutant mice, which show a cerebellar foliation patterning defect. Strikingly, four of the Wnt-7B expression domains that are adjacent to the En-2 domains are lost in En-2 mutant embryonic cerebella. These studies provide the first evidence of a potential network of regulatory genes that establish spatial cues in the developing cerebellum by dividing it into a grid of positional information required for patterning foliation and afferents. Taken together with previous gene expression studies, our data suggests that eleven sagittal domains and at least two anterior/posterior compartments are the basic elements of spatial information in the cerebellum.
This article has been cited by other articles:
|
|
 |
|
  S. K. Sgaier, Z. Lao, M. P. Villanueva, F. Berenshteyn, D. Stephen, R. K. Turnbull, and A. L. Joyner Genetic subdivision of the tectum and cerebellum into functionally related regions based on differential sensitivity to engrailed proteins Development, June 15, 2007; 134(12): 2325 - 2335. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Wang, D. Mullikin-Kilpatrick, J. E. Crandall, R. M. Gronostajski, E. D. Litwack, and D. L. Kilpatrick Nuclear Factor I Coordinates Multiple Phases of Cerebellar Granule Cell Development via Regulation of Cell Adhesion Molecules J. Neurosci., June 6, 2007; 27(23): 6115 - 6127. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. H. Friedel, G. Kerjan, H. Rayburn, U. Schuller, C. Sotelo, M. Tessier-Lavigne, and A. Chedotal Plexin-B2 Controls the Development of Cerebellar Granule Cells J. Neurosci., April 4, 2007; 27(14): 3921 - 3932. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Morales and M. E. Hatten Molecular Markers of Neuronal Progenitors in the Embryonic Cerebellar Anlage. J. Neurosci., November 22, 2006; 26(47): 12226 - 12236. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. S. Banting, O. Barak, T. M. Ames, A. C. Burnham, M. D. Kardel, N. S. Cooch, C. E. Davidson, R. Godbout, H. E. McDermid, and R. Shiekhattar CECR2, a protein involved in neurulation, forms a novel chromatin remodeling complex with SNF2L Hum. Mol. Genet., February 15, 2005; 14(4): 513 - 524. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Corrales, G. L. Rocco, S. Blaess, Q. Guo, and A. L. Joyner Spatial pattern of sonic hedgehog signaling through Gli genes during cerebellum development Development, November 15, 2004; 131(22): 5581 - 5590. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hashimoto and K. Mikoshiba Mediolateral Compartmentalization of the Cerebellum Is Determined on the "Birth Date" of Purkinje Cells J. Neurosci., December 10, 2003; 23(36): 11342 - 11351. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Aruga, T. Inoue, J. Hoshino, and K. Mikoshiba Zic2 Controls Cerebellar Development in Cooperation with Zic1 J. Neurosci., January 1, 2002; 22(1): 218 - 225. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Y. H. Li and A. L. Joyner Otx2 and Gbx2 are required for refinement and not induction of mid-hindbrain gene expression Development, December 15, 2001; 128(24): 4979 - 4991. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A Liu and A. Joyner EN and GBX2 play essential roles downstream of FGF8 in patterning the mouse mid/hindbrain region Development, January 1, 2001; 128(2): 181 - 191. [Abstract] [PDF]
|
|
|
|
 |
|
 H. B. Sarnat Molecular Genetic Classification of Central Nervous System Malformations J Child Neurol, October 1, 2000; 15(10): 675 - 687. [Abstract] [PDF]
|
|
|
|
|
|
H. B. Samat and J. H. Menkes How to Construct a Neural Tube J Child Neurol, February 1, 2000; 15(2): 110 - 124. [PDF]
|
|
|
|
|
|
K. J. Millen, J. H. Millonig, R. J. T. Wingate, J. Alder, and M. E. Hatten Neurogenetics of the Cerebellar System J Child Neurol, September 1, 1999; 14(9): 574 - 581. [Abstract] [PDF]
|
|
|
|
|
|
S. L. Baader, M. W. Vogel, S. Sanlioglu, X. Zhang, and J. Oberdick Selective Disruption of "Late Onset" Sagittal Banding Patterns by Ectopic Expression of Engrailed-2 in Cerebellar Purkinje Cells J. Neurosci., July 1, 1999; 19(13): 5370 - 5379. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A Liu, K Losos, and A. Joyner FGF8 can activate Gbx2 and transform regions of the rostral mouse brain into a hindbrain fate Development, January 11, 1999; 126(21): 4827 - 4838. [Abstract] [PDF]
|
|
|
|
|
|
N Dahmane and A Ruiz-i-Altaba Sonic hedgehog regulates the growth and patterning of the cerebellum Development, January 6, 1999; 126(14): 3089 - 3100. [Abstract] [PDF]
|
|
|
|
|
|
J. Huard, C. Forster, M. Carter, P Sicinski, and M. Ross Cerebellar histogenesis is disturbed in mice lacking cyclin D2 Development, January 5, 1999; 126(9): 1927 - 1935. [Abstract] [PDF]
|
|
|
|
|
|
H Shamim, R Mahmood, C Logan, P Doherty, A Lumsden, and I Mason Sequential roles for Fgf4, En1 and Fgf8 in specification and regionalisation of the midbrain Development, January 2, 1999; 126(5): 945 - 959. [Abstract] [PDF]
|
|
|
|
|
|
J. C. Lin and C. L. Cepko Granule Cell Raphes and Parasagittal Domains of Purkinje Cells: Complementary Patterns in the Developing Chick Cerebellum J. Neurosci., November 15, 1998; 18(22): 9342 - 9353. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Baader, S. Sanlioglu, A. S. Berrebi, J. Parker-Thornburg, and J. Oberdick Ectopic Overexpression of Engrailed-2 in Cerebellar Purkinje Cells Causes Restricted Cell Loss and Retarded External Germinal Layer Development at Lobule Junctions J. Neurosci., March 1, 1998; 18(5): 1763 - 1773. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Aruga, O. Minowa, H. Yaginuma, J. Kuno, T. Nagai, T. Noda, and K. Mikoshiba Mouse Zic1 Is Involved in Cerebellar Development J. Neurosci., January 1, 1998; 18(1): 284 - 293. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Kuemerle, H. Zanjani, A. Joyner, and K. Herrup Pattern Deformities and Cell Loss in Engrailed-2 Mutant Mice Suggest Two Separate Patterning Events during Cerebellar Development J. Neurosci., October 15, 1997; 17(20): 7881 - 7889. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Urbanek, I. Fetka, M. H. Meisler, and M. Busslinger Cooperation of Pax2 and Pax5 in midbrain and cerebellum development PNAS, May 27, 1997; 94(11): 5703 - 5708. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L Mathis, C Bonnerot, L Puelles, and J. Nicolas Retrospective clonal analysis of the cerebellum using genetic laacZ/lacZ mouse mosaics Development, January 10, 1997; 124(20): 4089 - 4104. [Abstract] [PDF]
|
|
|
|
|
|
S. Lee, P. Danielian, B Fritzsch, and A. McMahon Evidence that FGF8 signalling from the midbrain-hindbrain junction regulates growth and polarity in the developing midbrain Development, January 3, 1997; 124(5): 959 - 969. [Abstract] [PDF]
|
|
|
|
|
|
A Chedotal, E Bloch-Gallego, and C Sotelo The embryonic cerebellum contains topographic cues that guide developing inferior olivary axons Development, January 2, 1997; 124(4): 861 - 870. [Abstract] [PDF]
|
|
|
|
|
|
S Millet, E Bloch-Gallego, A Simeone, and R. Alvarado-Mallart The caudal limit of Otx2 gene expression as a marker of the midbrain/hindbrain boundary: a study using in situ hybridisation and chick/quail homotopic grafts Development, January 12, 1996; 122(12): 3785 - 3797. [Abstract] [PDF]
|
|
