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Development, Vol 121, Issue 12 4037-4044, Copyright © 1995 by Company of Biologists
JOURNAL ARTICLES |
AS Manoukian, KB Yoffe, EL Wilder and N Perrimon
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
The Drosophila segment polarity gene wingless (wg) is required in the regulation of engrailed (en) expression and the determination of cell fates in neighboring cells. This paracrine wg activity also regulates transcription of wg itself, through a positive feedback loop including en activity. In addition, wg has a second, more direct autoregulatory requirement that is distinct from the en-dependent feedback loop. Four gene products, encoded by armadillo (arm), dishevelled (dsh), porcupine (porc) and zeste-white 3 (zw3), have been previously implicated as components of wg paracrine signaling. Here we have used three different assays to assess the requirements of these genes in the more direct wg autoregulatory pathway. While the activities of dsh, zw3 and arm appear to be specific to the paracrine feedback pathway, the more direct autoregulatory pathway requires porc.
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U Hacker, X Lin, and N Perrimon The Drosophila sugarless gene modulates Wingless signaling and encodes an enzyme involved in polysaccharide biosynthesis Development, January 9, 1997; 124(18): 3565 - 3573. [Abstract] [PDF]
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R. Binari, B. Staveley, W. Johnson, R Godavarti, R Sasisekharan, and A. Manoukian Genetic evidence that heparin-like glycosaminoglycans are involved in wingless signaling Development, January 7, 1997; 124(13): 2623 - 2632. [Abstract] [PDF]
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W Shen and G Mardon Ectopic eye development in Drosophila induced by directed dachshund expression Development, January 1, 1997; 124(1): 45 - 52. [Abstract] [PDF]
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T Kadowaki, E Wilder, J Klingensmith, K Zachary, and N Perrimon The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing. Genes & Dev., December 15, 1996; 10(24): 3116 - 3128. [Abstract] [PDF]
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K. Cadigan and R Nusse wingless signaling in the Drosophila eye and embryonic epidermis Development, January 9, 1996; 122(9): 2801 - 2812. [Abstract] [PDF]
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