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Development, Vol 121, Issue 12 4215-4225, Copyright © 1995 by Company of Biologists
JOURNAL ARTICLES |
FJ Diaz-Benjumea and SM Cohen
Differentiation Program, European Molecular Biology Laboratory, Heidelberg, Germany.
Growth and patterning of the Drosophila wing is controlled by organizing centers located at the anterior-posterior and dorsal-ventral compartment boundaries. Interaction between cells in adjacent compartments establish the organizer. We report here that Serrate and Notch mediate the interaction between dorsal and ventral cells to direct localized expression of Wingless at the D/V boundary. Serrate serves as a spatially localized ligand which directs Wg expression through activation of Notch. Ligand independent activation of Notch is sufficient to direct Wg expression, which in turn mediates the organizing activity of the D/V boundary.
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E. Wiellette and W McGinnis Hox genes differentially regulate Serrate to generate segment-specific structures Development, January 5, 1999; 126(9): 1985 - 1995. [Abstract] [PDF]
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P Ligoxygakis, S. Bray, Y Apidianakis, and C Delidakis Ectopic expression of individual E(spl) genes has differential effects on different cell fate decisions and underscores the biphasic requirement for notch activity in wing margin establishment in Drosophila Development, January 5, 1999; 126(10): 2205 - 2214. [Abstract] [PDF]
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R Nagaraj, A. Pickup, R Howes, K Moses, M Freeman, and U Banerjee Role of the EGF receptor pathway in growth and patterning of the Drosophila wing through the regulation of vestigial Development, January 2, 1999; 126(5): 975 - 985. [Abstract] [PDF]
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