|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 121, Issue 3 731-742, Copyright © 1995 by Company of Biologists
JOURNAL ARTICLES |
B Wehrle-Haller and JA Weston
Institute of Neuroscience, University of Oregon, Eugene 97403.
Trunk neural crest cells segregate from the neuroepithelium and enter a 'migration staging area' lateral to the embryonic neural tube. After some crest cells in the migration staging area have begun to migrate on a medial pathway, a subpopulation of crest-derived cells remaining in the migration staging area expresses mRNAs for the receptor tyrosine kinase, c-kit, and tyrosinase-related protein-2, both of which are characteristic of melanocyte precursors. These putative melanocyte precursors are subsequently observed on the lateral crest migration pathway between the dermatome and overlying epithelium, and then dispersed in nascent dermal mesenchyme. Melanocyte precursors transiently require the c-kit ligand, Steel factor for survival. Although Steel factor mRNA is transiently expressed in the dorsal dermatome before the onset of trunk neural crest cell dispersal on the lateral pathway, it is no longer produced by dermatomal cells when melanocyte precursors have dispersed in the dermal mesenchyme. To assess the role of Steel factor in migration of melanocyte precursors on the lateral pathway, we analyzed melanocyte precursor dispersal and fate on the lateral pathway of two different Sl mutants, Sl, a null allele, and Sld, which lacks cell surface-associated Steel factor but produces a soluble form. No melanocyte precursors were detected in the dermatome of embryos homozygous for the Sl allele or in W mutants that lack functional c-kit. In contrast, in embryos homozygous for the Sld allele, melanocyte precursors appeared on the lateral pathway, but subsequently disappear from the dermis. These results suggest that soluble Steel factor is required for melanocyte precursor dispersal on the lateral pathway, or for their initial survival in the migration staging area. In contrast, membrane-bound Steel factor appears to promote melanocyte precursor survival in the dermis.
This article has been cited by other articles:
|
|
 |
|
  K. S.M. Smalley, R. Contractor, T. K. Nguyen, M. Xiao, R. Edwards, V. Muthusamy, A. J. King, K. T. Flaherty, M. Bosenberg, M. Herlyn, et al. Identification of a Novel Subgroup of Melanomas with KIT/Cyclin-Dependent Kinase-4 Overexpression Cancer Res., July 15, 2008; 68(14): 5743 - 5752. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Heaney, M.-Y. J. Lam, M. V. Michelson, and J. H. Nadeau Loss of the Transmembrane but not the Soluble Kit Ligand Isoform Increases Testicular Germ Cell Tumor Susceptibility in Mice Cancer Res., July 1, 2008; 68(13): 5193 - 5197. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. G. Mills, R. J. Nuckels, and D. M. Parichy Deconstructing evolution of adult phenotypes: genetic analyses of kit reveal homology and evolutionary novelty during adult pigment pattern development of Danio fishes Development, March 15, 2007; 134(6): 1081 - 1090. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Svetic, G. E. Hollway, S. Elworthy, T. R. Chipperfield, C. Davison, R. J. Adams, J. S. Eisen, P. W. Ingham, P. D. Currie, and R. N. Kelsh Sdf1a patterns zebrafish melanophores and links the somite and melanophore pattern defects in choker mutants Development, March 1, 2007; 134(5): 1011 - 1022. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Bashamboo, A. H. Taylor, K. Samuel, J.-J. Panthier, A. D. Whetton, and L. M. Forrester The survival of differentiating embryonic stem cells is dependent on the SCF-KIT pathway J. Cell Sci., August 1, 2006; 119(15): 3039 - 3046. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K.J. Hutt, E.A. McLaughlin, and M.K. Holland Kit ligand and c-Kit have diverse roles during mammalian oogenesis and folliculogenesis Mol. Hum. Reprod., February 1, 2006; 12(2): 61 - 69. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Paulhe, B. A. Imhof, and B. Wehrle-Haller A Specific Endoplasmic Reticulum Export Signal Drives Transport of Stem Cell Factor (Kitl) to the Cell Surface J. Biol. Chem., December 31, 2004; 279(53): 55545 - 55555. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. M. Wilson, K. L. Richards, M. L. Ford-Perriss, J.-J. Panthier, and M. Murphy Neural crest cell lineage segregation in the mouse neural tube Development, December 15, 2004; 131(24): 6153 - 6162. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. K. Williamson, B. C. Dibling, J. R. Boyne, P. Selby, and S. A. Burchill Basic Fibroblast Growth Factor-induced Cell Death Is Effected through Sustained Activation of p38MAPK and Up-regulation of the Death Receptor p75NTR J. Biol. Chem., November 12, 2004; 279(46): 47912 - 47928. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Slominski, D. J. Tobin, S. Shibahara, and J. Wortsman Melanin Pigmentation in Mammalian Skin and Its Hormonal Regulation Physiol Rev, October 1, 2004; 84(4): 1155 - 1228. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. M. Le Douarin, S. Creuzet, G. Couly, and E. Dupin Neural crest cell plasticity and its limits Development, October 1, 2004; 131(19): 4637 - 4650. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. Bland, R. C. Fowkes, and H. A. Ingraham Differential Requirement for Steroidogenic Factor-1 Gene Dosage in Adrenal Development Versus Endocrine Function Mol. Endocrinol., April 1, 2004; 18(4): 941 - 952. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Trainor and M. A. Nieto Jawsfest: new perspectives on neural crest lineages and morphogenesis Development, November 1, 2003; 130(21): 5059 - 5063. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. M. J. Peters, D. J. Tobin, N. Botchkareva, M. Maurer, and R. Paus Migration of Melanoblasts into the Developing Murine Hair Follicle Is Accompanied by Transient c-Kit Expression J. Histochem. Cytochem., June 1, 2002; 50(6): 751 - 766. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Dutton, A. Pauliny, S. S. Lopes, S. Elworthy, T. J. Carney, J. Rauch, R. Geisler, P. Haffter, and R. N. Kelsh Zebrafish colourless encodes sox10 and specifies non-ectomesenchymal neural crest fates Development, November 1, 2001; 128(21): 4113 - 4125. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Bagnard, C. Vaillant, S.-T. Khuth, N. Dufay, M. Lohrum, A. W. Puschel, M.-F. Belin, J. Bolz, and N. Thomasset Semaphorin 3A-Vascular Endothelial Growth Factor-165 Balance Mediates Migration and Apoptosis of Neural Progenitor Cells by the Recruitment of Shared Receptor J. Neurosci., May 15, 2001; 21(10): 3332 - 3341. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. R. Goding Mitf from neural crest to melanoma: signal transduction and transcription in the melanocyte lineage Genes & Dev., July 15, 2000; 14(14): 1712 - 1728. [Full Text]
|
|
|
|
|
|
L Hou, J. Panthier, and H Arnheiter Signaling and transcriptional regulation in the neural crest-derived melanocyte lineage: interactions between KIT and MITF Development, January 12, 2000; 127(24): 5379 - 5389. [Abstract] [PDF]
|
|
|
|
|
|
J. Rawls and S. Johnson Zebrafish kit mutation reveals primary and secondary regulation of melanocyte development during fin stripe regeneration Development, January 9, 2000; 127(17): 3715 - 3724. [Abstract] [PDF]
|
|
|
|
|
|
D. Parichy, D. Ransom, B Paw, L. Zon, and S. Johnson An orthologue of the kit-related gene fms is required for development of neural crest-derived xanthophores and a subpopulation of adult melanocytes in the zebrafish, Danio rerio Development, January 7, 2000; 127(14): 3031 - 3044. [Abstract] [PDF]
|
|
|
|
 |
|
 J. Liu, P. Tzou, R. J. Hill, and P. W. Sternberg Structural Requirements for the Tissue-Specific and Tissue-General Functions of the Caenorhabditis elegans Epidermal Growth Factor LIN-3 Genetics, November 1, 1999; 153(3): 1257 - 1269. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. M. Lichanska, C. M. Browne, G. W. Henkel, K. M. Murphy, M. C. Ostrowski, S. R. McKercher, R. A. Maki, and D. A. Hume Differentiation of the Mononuclear Phagocyte System During Mouse Embryogenesis: The Role of Transcription Factor PU.1 Blood, July 1, 1999; 94(1): 127 - 138. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. J. Painter, P. K. Maini, and H. G. Othmer Stripe formation in juvenile Pomacanthus explained by a generalized Turing mechanism with chemotaxis PNAS, May 11, 1999; 96(10): 5549 - 5554. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Parichy, J. Rawls, S. Pratt, T. Whitfield, and S. Johnson Zebrafish sparse corresponds to an orthologue of c-kit and is required for the morphogenesis of a subpopulation of melanocytes, but is not essential for hematopoiesis or primordial germ cell development Development, January 8, 1999; 126(15): 3425 - 3436. [Abstract] [PDF]
|
|
|
|
|
|
R. Lahav, E. Dupin, L. Lecoin, C. Glavieux, D. Champeval, C. Ziller, and N. M. Le Douarin Endothelin 3 selectively promotes survival and proliferation of neural crest-derived glial and melanocytic precursors in vitro PNAS, November 24, 1998; 95(24): 14214 - 14219. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Chin, G. Merlino, and R. A. DePinho Malignant melanoma: modern black plague and genetic black box Genes & Dev., November 15, 1998; 12(22): 3467 - 3481. [Full Text]
|
|
|
|
|
|
R. B. Hough, A. Lengeling, V. Bedian, C. Lo, and M. Bucan Rump white inversion in the mouse disrupts dipeptidyl aminopeptidase-like protein 6 and causes dysregulation of Kit expression PNAS, November 10, 1998; 95(23): 13800 - 13805. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Kunisada, S.-Z. Lu, H. Yoshida, S. Nishikawa, S.-i. Nishikawa, M. Mizoguchi, S.-i. Hayashi, L. Tyrrell, D. A. Williams, X. Wang, et al. Murine Cutaneous Mastocytosis and Epidermal Melanocytosis Induced by Keratinocyte Expression of Transgenic Stem Cell Factor J. Exp. Med., May 18, 1998; 187(10): 1565 - 1573. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Lecoin, T. Sakurai, M.-T. Ngo, Y. Abe, M. Yanagisawa, and N. M. Le Douarin Cloning and characterization of a novel endothelin receptor subtype in the avian class PNAS, March 17, 1998; 95(6): 3024 - 3029. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y Wakamatsu, M Mochii, K. Vogel, and J. Weston Avian neural crest-derived neurogenic precursors undergo apoptosis on the lateral migration pathway Development, January 11, 1998; 125(21): 4205 - 4213. [Abstract] [PDF]
|
|
|
|
|
|
T Kunisada, H Yoshida, H Yamazaki, A Miyamoto, H Hemmi, E Nishimura, L. Shultz, S Nishikawa, and S Hayashi Transgene expression of steel factor in the basal layer of epidermis promotes survival, proliferation, differentiation and migration of melanocyte precursors Development, January 8, 1998; 125(15): 2915 - 2923. [Abstract] [PDF]
|
|
|
|
|
|
B. J. Longley, L. Tyrrell, Y. Ma, D. A. Williams, R. Halaban, K. Langley, H. S. Lu, and N. M. Schechter Chymase cleavage of stem cell factor yields a bioactive, soluble product PNAS, August 19, 1997; 94(17): 9017 - 9021. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. C. Broudy Stem Cell Factor and Hematopoiesis Blood, August 15, 1997; 90(4): 1345 - 1364. [Full Text] [PDF]
|
|
|
|
|
|
P. Henion and J. Weston Timing and pattern of cell fate restrictions in the neural crest lineage Development, January 11, 1997; 124(21): 4351 - 4359. [Abstract] [PDF]
|
|
|
|
|
|
D Meyer, T Yamaai, A Garratt, E Riethmacher-Sonnenberg, D Kane, L. Theill, and C Birchmeier Isoform-specific expression and function of neuregulin Development, January 9, 1997; 124(18): 3575 - 3586. [Abstract] [PDF]
|
|
|
|
|
|
K Opdecamp, A Nakayama, M. Nguyen, C. Hodgkinson, W. Pavan, and H Arnheiter Melanocyte development in vivo and in neural crest cell cultures: crucial dependence on the Mitf basic-helix-loop-helix-zipper transcription factor Development, January 6, 1997; 124(12): 2377 - 2386. [Abstract] [PDF]
|
|
|
|
|
|
M Kluppel, D. Nagle, M Bucan, and A Bernstein Long-range genomic rearrangements upstream of Kit dysregulate the developmental pattern of Kit expression in W57 and Wbanded mice and interfere with distinct steps in melanocyte development Development, January 1, 1997; 124(1): 65 - 77. [Abstract] [PDF]
|
|
|
|
|
|
R. Kelsh, M Brand, Y. Jiang, C. Heisenberg, S Lin, P Haffter, J Odenthal, M. Mullins, F. van Eeden, M Furutani-Seiki, et al. Zebrafish pigmentation mutations and the processes of neural crest development Development, January 12, 1996; 123(1): 369 - 389. [Abstract] [PDF]
|
|
|
|
|
|
K Reid, A. Turnley, G. Maxwell, Y Kurihara, H Kurihara, P. Bartlett, and M Murphy Multiple roles for endothelin in melanocyte development: regulation of progenitor number and stimulation of differentiation Development, January 12, 1996; 122(12): 3911 - 3919. [Abstract] [PDF]
|
|
|
|
|
|
H Yoshida, T Kunisada, M Kusakabe, S Nishikawa, and S. Nishikawa Distinct stages of melanocyte differentiation revealed by anlaysis of nonuniform pigmentation patterns Development, January 4, 1996; 122(4): 1207 - 1214. [Abstract] [PDF]
|
|
|
|
|
|
D. Raible and J. Eisen Regulative interactions in zebrafish neural crest Development, January 2, 1996; 122(2): 501 - 507. [Abstract] [PDF]
|
|
