|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 121, Issue 5 1533-1545, Copyright © 1995 by Company of Biologists
JOURNAL ARTICLES |
RA Conlon, AG Reaume and J Rossant
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
Members of the Notch family of transmembrane receptors mediate a number of developmental decisions in invertebrates. In order to study Notch function in a vertebrate organism, we have mutated the Notch1 gene of the mouse. Notch1 gene function is required for embryonic survival in the second half of gestation. In the first half of gestation, we have found no effect of the mutation on the normal programs of neurogenesis, myogenesis or apoptosis. We conclude that Notch1 function is not essential for these processes, at least in early postimplantation development. However, we have found that somitogenesis is delayed and disorganized in Notch1 mutant embryos. We propose that Notch1 normally coordinates the process of somitogenesis, and we provide a model of how this might occur.
This article has been cited by other articles:
|
|
 |
|
  Y. H. Kim, H. Hu, S. Guevara-Gallardo, M. T. Y. Lam, S.-Y. Fong, and R. A. Wang Artery and vein size is balanced by Notch and ephrin B2/EphB4 during angiogenesis Development, November 15, 2008; 135(22): 3755 - 3764. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Urs, A. Roudabush, C. F. O'Neill, I. Pinz, I. Prudovsky, D. Kacer, Y. Tang, L. Liaw, and D. Small Soluble Forms of the Notch Ligands Delta1 and Jagged1 Promote in Vivo Tumorigenicity in NIH3T3 Fibroblasts with Distinct Phenotypes Am. J. Pathol., September 1, 2008; 173(3): 865 - 878. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Feller, A. Schneider, K. Schuster-Gossler, and A. Gossler Noncyclic Notch activity in the presomitic mesoderm demonstrates uncoupling of somite compartmentalization and boundary formation Genes & Dev., August 15, 2008; 22(16): 2166 - 2171. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. Jayasena, T. Ohyama, N. Segil, and A. K. Groves Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode Development, July 1, 2008; 135(13): 2251 - 2261. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Zhang, Y. Yang, P. A. Zweidler-McKay, and D. P.M. Hughes Critical Role of Notch Signaling in Osteosarcoma Invasion and Metastasis Clin. Cancer Res., May 15, 2008; 14(10): 2962 - 2969. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Yamaguchi, T. Oyama, E. Ito, H. Satoh, S. Azuma, M. Hayashi, K. Shimizu, R. Honma, Y. Yanagisawa, A. Nishikawa, et al. NOTCH3 Signaling Pathway Plays Crucial Roles in the Proliferation of ErbB2-Negative Human Breast Cancer Cells Cancer Res., March 15, 2008; 68(6): 1881 - 1888. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Bai, R. Kopan, W. Zou, M. J. Hilton, C.-t. Ong, F. Long, F. P. Ross, and S. L. Teitelbaum NOTCH1 Regulates Osteoclastogenesis Directly in Osteoclast Precursors and Indirectly via Osteoblast Lineage Cells J. Biol. Chem., March 7, 2008; 283(10): 6509 - 6518. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Ge and P. Stanley The O-fucose glycan in the ligand-binding domain of Notch1 regulates embryogenesis and T cell development PNAS, February 5, 2008; 105(5): 1539 - 1544. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Tan, F. Reza, and L. You Noise-Limited Frequency Signal Transmission in Gene Circuits Biophys. J., December 1, 2007; 93(11): 3753 - 3761. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. S. Hodkinson, Paul. A. Elliott, Y. Lad, B. J. McHugh, A. C. MacKinnon, C. Haslett, and T. Sethi Mammalian NOTCH-1 Activates beta1 Integrins via the Small GTPase R-Ras J. Biol. Chem., September 28, 2007; 282(39): 28991 - 29001. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. J. Hofmann and M. L. Iruela-Arispe Notch Signaling in Blood Vessels: Who Is Talking to Whom About What? Circ. Res., June 8, 2007; 100(11): 1556 - 1568. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Sun, L. Li, C. Vercherat, N. T. Gulbagci, S. Acharjee, J. Li, T.-K. Chung, T. H. Thin, and R. Taneja Stra13 regulates satellite cell activation by antagonizing Notch signaling J. Cell Biol., May 21, 2007; 177(4): 647 - 657. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Bolos, J. Grego-Bessa, and J. L. de la Pompa Notch Signaling in Development and Cancer Endocr. Rev., May 1, 2007; 28(3): 339 - 363. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-T. Cheng, M. Kim, M. T. Valerius, K. Surendran, K. Schuster-Gossler, A. Gossler, A. P. McMahon, and R. Kopan Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron Development, February 15, 2007; 134(4): 801 - 811. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Kusumi and P. D. Turnpenny Formation Errors of the Vertebral Column J. Bone Joint Surg. Am., February 1, 2007; 89(suppl_1): 64 - 71. [Full Text] [PDF]
|
|
|
|
|
|
K. Takeshita, M. Satoh, M. Ii, M. Silver, F. P. Limbourg, Y. Mukai, Y. Rikitake, F. Radtke, T. Gridley, D. W. Losordo, et al. Critical Role of Endothelial Notch1 Signaling in Postnatal Angiogenesis Circ. Res., January 5, 2007; 100(1): 70 - 78. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Nakagawa, M. Ichikawa, K. Kumano, S. Goyama, M. Kawazu, T. Asai, S. Ogawa, M. Kurokawa, and S. Chiba AML1/Runx1 rescues Notch1-null mutation-induced deficiency of para-aortic splanchnopleural hematopoiesis Blood, November 15, 2006; 108(10): 3329 - 3334. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. Rutenberg, A. Fischer, H. Jia, M. Gessler, T. P. Zhong, and M. Mercola Developmental patterning of the cardiac atrioventricular canal by Notch and Hairy-related transcription factors Development, November 1, 2006; 133(21): 4381 - 4390. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Chiba Concise Review: Notch Signaling in Stem Cell Systems Stem Cells, November 1, 2006; 24(11): 2437 - 2447. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Weinmaster and R. Kopan A garden of Notch-ly delights Development, September 1, 2006; 133(17): 3277 - 3282. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Stahl, C. Ge, S. Shi, R. G. Pestell, and P. Stanley Notch1-Induced Transformation of RKE-1 Cells Requires Up-regulation of Cyclin D1. Cancer Res., August 1, 2006; 66(15): 7562 - 7570. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Cormier, S. Le Bras, C. Souilhol, S. Vandormael-Pournin, B. Durand, C. Babinet, P. Baldacci, and M. Cohen-Tannoudji The Murine Ortholog of Notchless, a Direct Regulator of the Notch Pathway in Drosophila melanogaster, Is Essential for Survival of Inner Cell Mass Cells. Mol. Cell. Biol., May 1, 2006; 26(9): 3541 - 3549. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. F. de Pooter, T. M. Schmitt, J. L. de la Pompa, Y. Fujiwara, S. H. Orkin, and J. C. Zuniga-Pflucker Notch Signaling Requires GATA-2 to Inhibit Myelopoiesis from Embryonic Stem Cells and Primary Hemopoietic Progenitors J. Immunol., May 1, 2006; 176(9): 5267 - 5275. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Yaron, C. Farhy, T. Marquardt, M. Applebury, and R. Ashery-Padan Notch1 functions to suppress cone-photoreceptor fate specification in the developing mouse retina Development, April 1, 2006; 133(7): 1367 - 1378. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Duvillie, M. Attali, A. Bounacer, P. Ravassard, A. Basmaciogullari, and R. Scharfmann The Mesenchyme Controls the Timing of Pancreatic {beta}-Cell Differentiation Diabetes, March 1, 2006; 55(3): 582 - 589. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-T. Ong, H.-T. Cheng, L.-W. Chang, T. Ohtsuka, R. Kageyama, G. D. Stormo, and R. Kopan Target Selectivity of Vertebrate Notch Proteins: COLLABORATION BETWEEN DISCRETE DOMAINS AND CSL-BINDING SITE ARCHITECTURE DETERMINES ACTIVATION PROBABILITY J. Biol. Chem., February 24, 2006; 281(8): 5106 - 5119. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Wang, Y.-w. Zhang, P. Sun, R. Liu, X. Zhang, X. Zhang, K. Xia, J. Xia, H. Xu, and Z. Zhang Transcriptional Regulation of PEN-2, a Key Component of the {gamma}-Secretase Complex, by CREB Mol. Cell. Biol., February 15, 2006; 26(4): 1347 - 1354. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Thomsen, P. Horn, F. Panitz, E. Bendixen, A. H. Petersen, L.-E. Holm, V. H. Nielsen, J. S. Agerholm, J. Arnbjerg, and C. Bendixen A missense mutation in the bovine SLC35A3 gene, encoding a UDP-N-acetylglucosamine transporter, causes complex vertebral malformation Genome Res., January 1, 2006; 16(1): 97 - 105. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Wines-Samuelson and J. Shen Presenilins in the Developing, Adult, and Aging Cerebral Cortex Neuroscientist, October 1, 2005; 11(5): 441 - 451. [Abstract] [PDF]
|
|
|
|
|
|
H. A. Mason, S. M. Rakowiecki, M. Raftopoulou, S. Nery, Y. Huang, T. Gridley, and G. Fishell Notch signaling coordinates the patterning of striatal compartments Development, October 1, 2005; 132(19): 4247 - 4258. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Kishi and J. D. Macklis Dissecting MECP2 Function in the Central Nervous System J Child Neurol, September 1, 2005; 20(9): 753 - 759. [Abstract] [PDF]
|
|
|
|
|
|
N. Kishi and J. D. Macklis Dissecting MECP2 Function in the Central Nervous System J Child Neurol, August 1, 2005; 20(8): 753 - 759. [Abstract] [PDF]
|
|
|
|
|
|
H. Lickert, B. Cox, C. Wehrle, M. M. Taketo, R. Kemler, and J. Rossant Dissecting Wnt/{beta}-catenin signaling during gastrulation using RNA interference in mouse embryos Development, June 1, 2005; 132(11): 2599 - 2609. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Chen and Q. Al-Awqati Segmental expression of Notch and Hairy genes in nephrogenesis Am J Physiol Renal Physiol, May 1, 2005; 288(5): F939 - F952. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. P. Limbourg, K. Takeshita, F. Radtke, R. T. Bronson, M. T. Chin, and J. K. Liao Essential Role of Endothelial Notch1 in Angiogenesis Circulation, April 12, 2005; 111(14): 1826 - 1832. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Proweller, W. S. Pear, and M. S. Parmacek Notch Signaling Represses Myocardin-induced Smooth Muscle Cell Differentiation J. Biol. Chem., March 11, 2005; 280(10): 8994 - 9004. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L. Hahn, J. Johnson, B. J. Beres, S. Howard, and J. Wilson-Rawls Lunatic fringe null female mice are infertile due to defects in meiotic maturation Development, February 15, 2005; 132(4): 817 - 828. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Ma, T. Li, D. L. Price, and P. C. Wong APH-1a Is the Principal Mammalian APH-1 Isoform Present in {gamma}-Secretase Complexes during Embryonic Development J. Neurosci., January 5, 2005; 25(1): 192 - 198. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Dubrulle and O. Pourquie Coupling segmentation to axis formation Development, December 1, 2004; 131(23): 5783 - 5793. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hofmann, K. Schuster-Gossler, M. Watabe-Rudolph, A. Aulehla, B. G. Herrmann, and A. Gossler WNT signaling, in synergy with T/TBX6, controls Notch signaling by regulating Dll1 expression in the presomitic mesoderm of mouse embryos Genes & Dev., November 15, 2004; 18(22): 2712 - 2717. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Galceran, C. Sustmann, S.-C. Hsu, S. Folberth, and R. Grosschedl LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesis Genes & Dev., November 15, 2004; 18(22): 2718 - 2723. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Hatakeyama, Y. Bessho, K. Katoh, S. Ookawara, M. Fujioka, F. Guillemot, and R. Kageyama Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation Development, November 15, 2004; 131(22): 5539 - 5550. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. K. Hadland, S. S. Huppert, J. Kanungo, Y. Xue, R. Jiang, T. Gridley, R. A. Conlon, A. M. Cheng, R. Kopan, and G. D. Longmore A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development Blood, November 15, 2004; 104(10): 3097 - 3105. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Aulehla and B. G. Herrmann Segmentation in vertebrates: clock and gradient finally joined Genes & Dev., September 1, 2004; 18(17): 2060 - 2067. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Hitoshi, R. M. Seaberg, C. Koscik, T. Alexson, S. Kusunoki, I. Kanazawa, S. Tsuji, and D. van der Kooy Primitive neural stem cells from the mammalian epiblast differentiate to definitive neural stem cells under the control of Notch signaling Genes & Dev., August 1, 2004; 18(15): 1806 - 1811. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Louvi, S. S. Sisodia, and E. A. Grove Presenilin 1 in migration and morphogenesis in the central nervous system Development, July 1, 2004; 131(13): 3093 - 3105. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Bussen, M. Petry, K. Schuster-Gossler, M. Leitges, A. Gossler, and A. Kispert The T-box transcription factor Tbx18 maintains the separation of anterior and posterior somite compartments Genes & Dev., May 15, 2004; 18(10): 1209 - 1221. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. H. Jensen, E. I. Jauho, E. Santoni-Rugiu, U. Holmskov, B. Teisner, N. Tygstrup, and H. C. Bisgaard Transit-Amplifying Ductular (Oval) Cells and Their Hepatocytic Progeny Are Characterized by a Novel and Distinctive Expression of Delta-Like Protein/Preadipocyte Factor 1/Fetal Antigen 1 Am. J. Pathol., April 1, 2004; 164(4): 1347 - 1359. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. T. Wong, D. Manfra, F. M. Poulet, Q. Zhang, H. Josien, T. Bara, L. Engstrom, M. Pinzon-Ortiz, J. S. Fine, H.-J. J. Lee, et al. Chronic Treatment with the {gamma}-Secretase Inhibitor LY-411,575 Inhibits {beta}-Amyloid Peptide Production and Alters Lymphopoiesis and Intestinal Cell Differentiation J. Biol. Chem., March 26, 2004; 279(13): 12876 - 12882. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Cordes, K. Schuster-Gossler, K. Serth, and A. Gossler Specification of vertebral identity is coupled to Notch signalling and the segmentation clock Development, March 15, 2004; 131(6): 1221 - 1233. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. T. Tetzlaff, W. Yu, M. Li, P. Zhang, M. Finegold, K. Mahon, J. W. Harper, R. J. Schwartz, and S. J. Elledge Inaugural Article, From The Cover: Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein PNAS, March 9, 2004; 101(10): 3338 - 3345. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Tsunematsu, K. Nakayama, Y. Oike, M. Nishiyama, N. Ishida, S. Hatakeyama, Y. Bessho, R. Kageyama, T. Suda, and K. I. Nakayama Mouse Fbw7/Sel-10/Cdc4 Is Required for Notch Degradation during Vascular Development J. Biol. Chem., March 5, 2004; 279(10): 9417 - 9423. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Qin, J. Wang, Y. Liang, Y. Taniguchi, K. Tanigaki, and H. Han RING1 inhibits transactivation of RBP-J by Notch through interaction with LIM protein KyoT2 Nucleic Acids Res., March 3, 2004; 32(4): 1492 - 1501. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. C. Lai Notch signaling: control of cell communication and cell fate Development, March 1, 2004; 131(5): 965 - 973. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Cuervo and L. Covarrubias Death is the major fate of medial edge epithelial cells and the cause of basal lamina degradation during palatogenesis Development, January 1, 2004; 131(1): 15 - 24. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Timmerman, J. Grego-Bessa, A. Raya, E. Bertran, J. M. Perez-Pomares, J. Diez, S. Aranda, S. Palomo, F. McCormick, J. C. Izpisua-Belmonte, et al. Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation Genes & Dev., January 1, 2004; 18(1): 99 - 115. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Dahlqvist, A. Blokzijl, G. Chapman, A. Falk, K. Dannaeus, C. F. Ibanez, and U. Lendahl Functional Notch signaling is required for BMP4-induced inhibition of myogenic differentiation Development, December 15, 2003; 130(24): 6089 - 6099. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Xiao, J.-h. Shim, M. Kluppel, S. S.-M. Zhang, C. Dong, R. A. Flavell, X.-Y. Fu, J. L. Wrana, B. L.M. Hogan, and S. Ghosh Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis Genes & Dev., December 1, 2003; 17(23): 2933 - 2949. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Cheng, Y. Nefedova, L. Miele, B. A. Osborne, and D. Gabrilovich Notch signaling is necessary but not sufficient for differentiation of dendritic cells Blood, December 1, 2003; 102(12): 3980 - 3988. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-T. Cheng, J. H. Miner, M. Lin, M. G. Tansey, K. Roth, and R. Kopan {gamma}-Secretase activity is dispensable for mesenchyme-to-epithelium transition but required for podocyte and proximal tubule formation in developing mouse kidney Development, October 15, 2003; 130(20): 5031 - 5042. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Wang, F. A. Pereira, D. Beasley, and H. Zheng Presenilins are required for the formation of comma- and S-shaped bodies during nephrogenesis Development, October 15, 2003; 130(20): 5019 - 5029. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. S. Mankoo, S. Skuntz, I. Harrigan, E. Grigorieva, A. Candia, C. V. E. Wright, H. Arnheiter, and V. Pachnis The concerted action of Meox homeobox genes is required upstream of genetic pathways essential for the formation, patterning and differentiation of somites Development, October 1, 2003; 130(19): 4655 - 4664. [Abstract] [Full Text] [PDF]
|
|
|
