|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 121, Issue 6 1743-1754, Copyright © 1995 by Company of Biologists
JOURNAL ARTICLES |
K Ono, R Bansal, J Payne, U Rutishauser and RH Miller
Department of Neuroscience and Genetics, Case Western Reserve University, Cleveland OH 44106, USA.
Oligodendrocytes, the myelinating cells of the vertebrate CNS, originally develop from cells of the neuroepithelium. Recent studies suggest that spinal cord oligodendrocyte precursors are initially localized in the region of the ventral ventricular zone and subsequently disperse throughout the spinal cord. The characteristics of these early oligodendrocyte precursors and their subsequent migration has been difficult to assay directly in the rodent spinal cord due to a lack of appropriate reagents. In the developing chick spinal cord, we show that oligodendrocyte precursors can be specifically identified by labeling with O4 monoclonal antibody. In contrast to rodent oligodendrocyte precursors, which express O4 immunoreactivity only during the later stages of maturation, in the chick O4 immunoreactivity appears very early and its expression is retained through cellular maturation. In embryos older than stage 35, O4+ cells represent the most immature, self-renewing, cells of the chick spinal cord oligodendrocyte lineage. In the intact chick spinal cord, the earliest O4+ cells are located at the ventral ventricular zone where they actually contribute to the ventricular lining of the central canal. The subsequent migration of O4+ cells into the dorsal region of the spinal cord temporally correlates with the capacity of isolated dorsal spinal cord to generate oligodendrocytes in vitro. Biochemical analysis suggests O4 labels a POA-like antigen on the surface of chick spinal cord oligodendrocyte precursors. These studies provide direct evidence for the ventral ventricular origin of spinal cord oligodendrocytes, and suggest that this focal source of oligodendrocytes is a general characteristic of vertebrate development.
This article has been cited by other articles:
|
|
 |
|
  S.-Z. Wang, J. Dulin, H. Wu, E. Hurlock, S.-E. Lee, K. Jansson, and Q. R. Lu An oligodendrocyte-specific zinc-finger transcription regulator cooperates with Olig2 to promote oligodendrocyte differentiation Development, September 1, 2006; 133(17): 3389 - 3398. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Gao and R. H. Miller Specification of optic nerve oligodendrocyte precursors by retinal ganglion cell axons. J. Neurosci., July 19, 2006; 26(29): 7619 - 7628. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Danesin, E. Agius, N. Escalas, X. Ai, C. Emerson, P. Cochard, and C. Soula Ventral neural progenitors switch toward an oligodendroglial fate in response to increased Sonic hedgehog (Shh) activity: involvement of Sulfatase 1 in modulating Shh signaling in the ventral spinal cord. J. Neurosci., May 10, 2006; 26(19): 5037 - 5048. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Fogarty, W. D. Richardson, and N. Kessaris A subset of oligodendrocytes generated from radial glia in the dorsal spinal cord Development, April 15, 2005; 132(8): 1951 - 1959. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Zhang, J. Cai, K. M. Klueber, Z. Guo, C. Lu, M. Qiu, and F. J. Roisen Induction of Oligodendrocytes From Adult Human Olfactory Epithelial-Derived Progenitors by Transcription Factors Stem Cells, March 1, 2005; 23(3): 442 - 453. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Chojnacki and S. Weiss Isolation of a Novel Platelet-Derived Growth Factor-Responsive Precursor from the Embryonic Ventral Forebrain J. Neurosci., December 1, 2004; 24(48): 10888 - 10899. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Samanta and J. A. Kessler Interactions between ID and OLIG proteins mediate the inhibitory effects of BMP4 on oligodendroglial differentiation Development, September 1, 2004; 131(17): 4131 - 4142. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Jarjour and T. E. Kennedy Oligodendrocyte Precursors on the Move: Mechanisms Directing Migration Neuroscientist, April 1, 2004; 10(2): 99 - 105. [Abstract] [PDF]
|
|
|
|
 |
|
 H. Nomoto, T. Yonezawa, K. Itoh, K. Ono, K. Yamamoto, T. Oohashi, F. Shiraga, H. Ohtsuki, and Y. Ninomiya Molecular Cloning of a Novel Transmembrane Protein MOLT Expressed by Mature Oligodendrocytes J. Biochem., August 1, 2003; 134(2): 231 - 238. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-H. Tsai, M. Tessier-Lavigne, and R. H. Miller Netrin 1 mediates spinal cord oligodendrocyte precursor dispersal Development, May 15, 2003; 130(10): 2095 - 2105. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Jarjour, C. Manitt, S. W. Moore, K. M. Thompson, S.-J. Yuh, and T. E. Kennedy Netrin-1 Is a Chemorepellent for Oligodendrocyte Precursor Cells in the Embryonic Spinal Cord J. Neurosci., May 1, 2003; 23(9): 3735 - 3744. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Mekki-Dauriac, E. Agius, P. Kan, and P. Cochard Bone morphogenetic proteins negatively control oligodendrocyte precursor specification in the chick spinal cord Development, March 13, 2003; 129(22): 5117 - 5130. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Fu, Y. Qi, M. Tan, J. Cai, H. Takebayashi, M. Nakafuku, W. Richardson, and M. Qiu Dual origin of spinal oligodendrocyte progenitors and evidence for the cooperative role of Olig2 and Nkx2.2 in the control of oligodendrocyte differentiation Development, January 2, 2002; 129(3): 681 - 693. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-K. Park, R. Miller, I. Krane, and T. Vartanian The erbB2 gene is required for the development of terminally differentiated spinal cord oligodendrocytes J. Cell Biol., September 17, 2001; 154(6): 1245 - 1258. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Qi, J. Cai, Y. Wu, R. Wu, J. Lee, H. Fu, M. Rao, L. Sussel, J. Rubenstein, and M. Qiu Control of oligodendrocyte differentiation by the Nkx2.2 homeodomain transcription factor Development, July 15, 2001; 128(14): 2723 - 2733. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C Olivier, I Cobos, E. Perez Villegas, N Spassky, B Zalc, S Martinez, and J. Thomas Monofocal origin of telencephalic oligodendrocytes in the anterior entopeduncular area of the chick embryo Development, January 5, 2001; 128(10): 1757 - 1769. [Abstract] [PDF]
|
|
|
|
|
|
C Soula, C Danesin, P Kan, M Grob, C Poncet, and P Cochard Distinct sites of origin of oligodendrocytes and somatic motoneurons in the chick spinal cord: oligodendrocytes arise from Nkx2.2-expressing progenitors by a Shh-dependent mechanism Development, January 4, 2001; 128(8): 1369 - 1379. [Abstract] [PDF]
|
|
|
|
|
|
K. Blaschuk, E. Frost, and C ffrench-Constant The regulation of proliferation and differentiation in oligodendrocyte progenitor cells by alphaV integrins Development, January 5, 2000; 127(9): 1961 - 1969. [Abstract] [PDF]
|
|
|
|
|
|
D Arendt and K Nubler-Jung Comparison of early nerve cord development in insects and vertebrates Development, January 6, 1999; 126(11): 2309 - 2325. [Abstract] [PDF]
|
|
|
|
|
|
D. Orentas, J. Hayes, K. Dyer, and R. Miller Sonic hedgehog signaling is required during the appearance of spinal cord oligodendrocyte precursors Development, January 6, 1999; 126(11): 2419 - 2429. [Abstract] [PDF]
|
|
|
|
|
|
M Fruttiger, L Karlsson, A. Hall, A Abramsson, A. Calver, H Bostrom, K Willetts, C. Bertold, J. Heath, C Betsholtz, et al. Defective oligodendrocyte development and severe hypomyelination in PDGF-A knockout mice Development, January 2, 1999; 126(3): 457 - 467. [Abstract] [PDF]
|
|
|
|
|
|
M. Hajihosseini, T. N. Tham, and M. Dubois-Dalcq Origin of Oligodendrocytes within the Human Spinal Cord J. Neurosci., December 15, 1996; 16(24): 7981 - 7994. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Zhang and R. H. Miller Density-Dependent Feedback Inhibition of Oligodendrocyte Precursor Expansion J. Neurosci., November 1, 1996; 16(21): 6886 - 6895. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A Hall, N. Giese, and W. Richardson Spinal cord oligodendrocytes develop from ventrally derived progenitor cells that express PDGF alpha-receptors Development, January 12, 1996; 122(12): 4085 - 4094. [Abstract] [PDF]
|
|
