|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 121, Issue 8 2265-2278, Copyright © 1995 by Company of Biologists
JOURNAL ARTICLES |
M Zecca, K Basler and G Struhl
Zoologisches Institut, Universitat Zurich, Switzerland.
The Drosophila wing is formed by two cell populations, the anterior and posterior compartments, which are distinguished by the activity of the selector gene engrailed (en) in posterior cells. Here, we show that en governs growth and patterning in both compartments by controlling the expression of the secreted proteins hedgehog (hh) and decapentaplegic (dpp) as well as the response of cells to these signaling molecules. First, we demonstrate that en activity programs wing cells to express hh whereas the absence of en activity programs them to respond to hh by expressing dpp. As a consequence, posterior cells secrete hh and induce a stripe of neighboring anterior cells across the compartment boundary to secrete dpp. Second, we demonstrate that dpp can exert a long-range organizing influence on surrounding wing tissue, specifying anterior or posterior pattern depending on the compartmental provenance, and hence the state of en activity, of the responding cells. Thus, dpp secreted by anterior cells along the compartment boundary has the capacity to organize the development of both compartments. Finally, we report evidence suggesting that dpp may exert its organizing influence by acting as a gradient morphogen in contrast to hh which appears to act principally as a short range inducer of dpp.
This article has been cited by other articles:
|
|
 |
|
  A. Gonzalez, C. Chaouiya, and D. Thieffry Logical modelling of the role of the Hh pathway in the patterning of the Drosophila wing disc Bioinformatics, August 15, 2008; 24(16): i234 - i240. [Abstract] [PDF]
|
|
|
|
 |
|
 F. Bejarano, C. M. Luque, H. Herranz, G. Sorrosal, N. Rafel, T. T. Pham, and M. Milan A Gain-of-Function Suppressor Screen for Genes Involved in Dorsal-Ventral Boundary Formation in the Drosophila Wing Genetics, January 1, 2008; 178(1): 307 - 323. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Zecca and G. Struhl Recruitment of cells into the Drosophila wing primordium by a feed-forward circuit of vestigial autoregulation Development, August 15, 2007; 134(16): 3001 - 3010. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Zecca and G. Struhl Control of Drosophila wing growth by the vestigial quadrant enhancer Development, August 15, 2007; 134(16): 3011 - 3020. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Emlen, L. Corley Lavine, and B. Ewen-Campen Colloquium Papers: On the origin and evolutionary diversification of beetle horns PNAS, May 15, 2007; 104(suppl_1): 8661 - 8668. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Molnar, H. Holguin, F. Mayor Jr., A. Ruiz-Gomez, and J. F. de Celis The G protein-coupled receptor regulatory kinase GPRK2 participates in Hedgehog signaling in Drosophila PNAS, May 8, 2007; 104(19): 7963 - 7968. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. F. de Navas, D. L. Garaulet, and E. Sanchez-Herrero The Ultrabithorax Hox gene of Drosophila controls haltere size by regulating the Dpp pathway Development, November 15, 2006; 133(22): 4495 - 4506. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Crickmore and R. S. Mann Hox Control of Organ Size by Regulation of Morphogen Production and Mobility Science, July 7, 2006; 313(5783): 63 - 68. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Dworkin and G. Gibson Epidermal Growth Factor Receptor and Transforming Growth Factor-{beta} Signaling Contributes to Variation for Wing Shape in Drosophila melanogaster Genetics, July 1, 2006; 173(3): 1417 - 1431. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Wehn and G. Campbell Genetic Interactions Among scribbler, Atrophin and groucho in Drosophila Uncover Links in Transcriptional Repression Genetics, June 1, 2006; 173(2): 849 - 861. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Callejo, C. Torroja, L. Quijada, and I. Guerrero Hedgehog lipid modifications are required for Hedgehog stabilization in the extracellular matrix Development, February 1, 2006; 133(3): 471 - 483. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Major and K. D. Irvine Influence of Notch on dorsoventral compartmentalization and actin organization in the Drosophila wing Development, September 1, 2005; 132(17): 3823 - 3833. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M. Zeltser Shh-dependent formation of the ZLI is opposed by signals from the dorsal diencephalon Development, May 1, 2005; 132(9): 2023 - 2033. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Hatini, R. B. Green, J. A. Lengyel, S. J. Bray, and S. DiNardo The Drumstick/Lines/Bowl regulatory pathway links antagonistic Hedgehog and Wingless signaling inputs to epidermal cell differentiation Genes & Dev., March 15, 2005; 19(6): 709 - 718. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. I. Shraiman Mechanical feedback as a possible regulator of tissue growth PNAS, March 1, 2005; 102(9): 3318 - 3323. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Angulo, M. Corominas, and F. Serras Activation and repression activities of ash2 in Drosophila wing imaginal discs Development, October 15, 2004; 131(20): 4943 - 4953. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. L. Jockusch and K. A. Ober Hypothesis Testing in Evolutionary Developmental Biology: A Case Study from Insect Wings J. Hered., September 1, 2004; 95(5): 382 - 396. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Rodriguez The dachsous gene, a member of the cadherin family, is required for Wg-dependent pattern formation in the Drosophila wing disc Development, July 1, 2004; 131(13): 3195 - 3206. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. S. Collier, K. Suyama, J. H. Anderson, and M. P. Scott Drosophila Costal1 Mutations Are Alleles of Protein Kinase A That Modulate Hedgehog Signaling Genetics, June 1, 2004; 167(2): 783 - 796. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Torroja, N. Gorfinkiel, and I. Guerrero Patched controls the Hedgehog gradient by endocytosis in a dynamin-dependent manner, but this internalization does not play a major role in signal transduction Development, May 15, 2004; 131(10): 2395 - 2408. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Tabata and Y. Takei Morphogens, their identification and regulation Development, February 15, 2004; 131(4): 703 - 712. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Han, T. Y. Belenkaya, B. Wang, and X. Lin Drosophila glypicans control the cell-to-cell movement of Hedgehog by a dynamin-independent process Development, February 1, 2004; 131(3): 601 - 611. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Takei, Y. Ozawa, M. Sato, A. Watanabe, and T. Tabata Three Drosophila EXT genes shape morphogen gradients through synthesis of heparan sulfate proteoglycans Development, January 1, 2004; 131(1): 73 - 82. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Thomas and P. W. Ingham Hedgehog Signaling in the Drosophila Eye and Head: An Analysis of the Effects of Different patched Trans-heterozygotes Genetics, December 1, 2003; 165(4): 1915 - 1928. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Emlen and C. E. Allen Genotype to Phenotype: Physiological Control of Trait Size and Scaling in Insects Integr. Comp. Biol., November 1, 2003; 43(5): 617 - 634. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Araujo, E. Negreiros, and E. Bier Integrins modulate Sog activity in the Drosophila wing Development, August 15, 2003; 130(16): 3851 - 3864. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Wang and R. S. Mann Requirement for two nearly identical TGIF-related homeobox genes in Drosophila spermatogenesis Development, July 1, 2003; 130(13): 2853 - 2865. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Lee, K. Amanai, A. Shearn, and J. E. Treisman The ubiquitin ligase Hyperplastic discs negatively regulates hedgehog and decapentaplegic expression by independent mechanisms Development, March 14, 2003; 129(24): 5697 - 5706. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Zecca and G. Struhl Subdivision of the Drosophila wing imaginal disc by EGFR-mediated signaling Development, March 5, 2003; 129(6): 1357 - 1368. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Micchelli, I. The, E. Selva, V. Mogila, and N. Perrimon rasp, a putative transmembrane acyltransferase, is required for Hedgehog signaling Development, March 4, 2003; 129(4): 843 - 851. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Martin-Castellanos and B. A. Edgar A characterization of the effects of Dpp signaling on cell growth and proliferation in the Drosophila wing Development, March 4, 2003; 129(4): 1003 - 1013. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Maurange and R. Paro A cellular memory module conveys epigenetic inheritance of hedgehog expression during Drosophila wing imaginal disc development Genes & Dev., October 15, 2002; 16(20): 2672 - 2683. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. R. Hipfner, K. Weigmann, and S. M. Cohen The bantam Gene Regulates Drosophila Growth Genetics, August 1, 2002; 161(4): 1527 - 1537. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Van De Bor, P. Heitzler, S. Leger, C. Plessy, and A. Giangrande Precocious Expression of the Glide/Gcm Glial-Promoting Factor in Drosophila Induces Neurogenesis Genetics, March 1, 2002; 160(3): 1095 - 1106. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Baonza and M. Freeman Control of Drosophila eye specification by Wingless signalling Development, January 12, 2002; 129(23): 5313 - 5322. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Milan, U. Weihe, S. Tiong, W. Bender, and S. M. Cohen msh specifies dorsal cell fate in the Drosophila wing Development, September 1, 2001; 128(17): 3263 - 3268. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Lee and J. Treisman The role of Wingless signaling in establishing the anteroposterior and dorsoventral axes of the eye disc Development, January 5, 2001; 128(9): 1519 - 1529. [Abstract] [PDF]
|
|
|
|
|
|
D. O'Keefe and J. Thomas Drosophila wing development in the absence of dorsal identity Development, January 3, 2001; 128(5): 703 - 710. [Abstract] [PDF]
|
|
|
|
|
|
N Methot and K Basler An absolute requirement for Cubitus interruptus in Hedgehog signaling Development, January 3, 2001; 128(5): 733 - 742. [Abstract] [PDF]
|
|
|
|
|
|
M Treier, S O'Connell, A Gleiberman, J Price, D. Szeto, R Burgess, P. Chuang, A. McMahon, and M. Rosenfeld Hedgehog signaling is required for pituitary gland development Development, January 2, 2001; 128(3): 377 - 386. [Abstract] [PDF]
|
|
|
|
|
|
Y Funakoshi, M Minami, and T Tabata mtv shapes the activity gradient of the Dpp morphogen through regulation of thickveins Development, January 1, 2001; 128(1): 67 - 74. [Abstract] [PDF]
|
|
|
|
|
|
N. Haines and M. van den Heuvel A Directed Mutagenesis Screen in Drosophila melanogaster Reveals New Mutants That Influence hedgehog Signaling Genetics, December 1, 2000; 156(4): 1777 - 1785. [Abstract] [Full Text]
|
|
|
|
|
|
W. Li, E. Noll, and N. Perrimon Identification of Autosomal Regions Involved in Drosophila Raf Function Genetics, October 1, 2000; 156(2): 763 - 774. [Abstract] [Full Text]
|
|
|
|
|
|
A. Baonza, F. Roch, and E. Martin-Blanco DER signaling restricts the boundaries of the wing field during Drosophila development PNAS, June 20, 2000; 97(13): 7331 - 7335. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Svendsen, S. Marshall, M Kyba, and W. Brook The combgap locus encodes a zinc-finger protein that regulates cubitus interruptus during limb development in Drosophila melanogaster Development, January 10, 2000; 127(19): 4083 - 4093. [Abstract] [PDF]
|
|
|
|
|
|
G. Campbell and A Tomlinson Transcriptional regulation of the Hedgehog effector CI by the zinc-finger gene combgap Development, January 10, 2000; 127(19): 4095 - 4103. [Abstract] [PDF]
|
|
|
|
|
|
N Methot and K Basler Suppressor of fused opposes hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus Development, January 9, 2000; 127(18): 4001 - 4010. [Abstract] [PDF]
|
|
|
|
|
|
S. Day and P. Lawrence Measuring dimensions: the regulation of size and shape Development, January 7, 2000; 127(14): 2977 - 2987. [Abstract] [PDF]
|
|
|
|
|
|
B Muller and K Basler The repressor and activator forms of Cubitus interruptus control Hedgehog target genes through common generic gli-binding sites Development, January 7, 2000; 127(14): 2999 - 3007. [Abstract] [PDF]
|
|
|
|
|
|
Q. Wang and R. Holmgren Nuclear import of cubitus interruptus is regulated by hedgehog via a mechanism distinct from Ci stabilization and Ci activation Development, January 7, 2000; 127(14): 3131 - 3139. [Abstract] [PDF]
|
|
|
|
|
|
K Certel, A Hudson, S. Carroll, and W. Johnson Restricted patterning of vestigial expression in Drosophila wing imaginal discs requires synergistic activation by both Mad and the drifter POU domain transcription factor Development, January 7, 2000; 127(14): 3173 - 3183. [Abstract] [PDF]
|
|
|
|
|
|
F Cavodeassi, J Modolell, and S Campuzano The Iroquois homeobox genes function as dorsal selectors in the Drosophila head Development, January 5, 2000; 127(9): 1921 - 1929. [Abstract] [PDF]
|
|
|
|
|
|
A Sukegawa, T Narita, T Kameda, K Saitoh, T Nohno, H Iba, S Yasugi, and K Fukuda The concentric structure of the developing gut is regulated by Sonic hedgehog derived from endodermal epithelium Development, January 5, 2000; 127(9): 1971 - 1980. [Abstract] [PDF]
|
|
|
|
|
|
C Maurel-Zaffran and J. Treisman pannier acts upstream of wingless to direct dorsal eye disc development in Drosophila Development, January 3, 2000; 127(5): 1007 - 1016. [Abstract] [PDF]
|
|
|
|
|
|
J Curtiss and M Mlodzik Morphogenetic furrow initiation and progression during eye development in Drosophila: the roles of decapentaplegic, hedgehog and eyes absent Development, January 3, 2000; 127(6): 1325 - 1336. [Abstract] [PDF]
|
|
|
|
|
|
L. Dobens, J. Peterson, J Treisman, and L. Raftery Drosophila bunched integrates opposing DPP and EGF signals to set the operculum boundary Development, January 2, 2000; 127(4): 745 - 754. [Abstract] [PDF]
|
|
|
|
|
|
J Mohler, M Seecoomar, S Agarwal, E Bier, and J Hsai Activation of knot (kn) specifies the 3-4 intervein region in the Drosophila wing Development, January 1, 2000; 127(1): 55 - 63. [Abstract] [PDF]
|
|
|
|
|
|
G. Wang, B. Wang, and J. Jiang Protein kinase A antagonizes Hedgehog signaling by regulating both the activator and repressor forms of Cubitus interruptus Genes & Dev., November 1, 1999; 13(21): 2828 - 2837. [Abstract] [Full Text]
|
|
|
|
|
|
T. R. Breen Mutant Alleles of the Drosophila trithorax Gene Produce Common and Unusual Homeotic and Other Developmental Phenotypes Genetics, May 1, 1999; 152(1): 319 - 344. [Abstract] [Full Text]
|
|
|
|
|
|
F Agnes, M Suzanne, and S Noselli The Drosophila JNK pathway controls the morphogenesis of imaginal discs during metamorphosis Development, January 12, 1999; 126(23): 5453 - 5462. [Abstract] [PDF]
|
|
|
|
|
|
S Greenwood and G Struhl Progression of the morphogenetic furrow in the Drosophila eye: the roles of Hedgehog, Decapentaplegic and the Raf pathway Development, January 12, 1999; 126(24): 5795 - 5808. [Abstract] [PDF]
|
|
|
|
|
|
U Gritzan, V Hatini, and S DiNardo Mutual antagonism between signals secreted by adjacent wingless and engrailed cells leads to specification of complementary regions of the Drosophila parasegment Development, January 9, 1999; 126(18): 4107 - 4115. [Abstract] [PDF]
|
|
|
|
|
|
A Kopp, R. Blackman, and I Duncan Wingless, decapentaplegic and EGF receptor signaling pathways interact to specify dorso-ventral pattern in the adult abdomen of Drosophila Development, January 8, 1999; 126(16): 3495 - 3507. [Abstract] [PDF]
|
|
|
|
|
|
G Morata and E Sanchez-Herrero Patterning mechanisms in the body trunk and the appendages of Drosophila Development, January 7, 1999; 126(13): 2823 - 2828. [Abstract] [PDF]
|
|
|
|
