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Development, Vol 121, Issue 8 2279-2289, Copyright © 1995 by Company of Biologists
JOURNAL ARTICLES |
C Ma and K Moses
Department of Biological Sciences, University of Southern California, Los Angeles 90089-1340, USA.
In the developing Drosophila compound eye, a wave of pattern formation and cell-type determination sweeps across the presumptive eye epithelium. This 'morphogenetic furrow' coordinates the epithelial cells' division cycle, shape and gene expression to produce evenly spaced neural cell clusters that will eventually form the adult ommatidia. As these clusters develop, they rotate inwards to face the eye's equator and establish tissue polarity. We have found that wingless is strongly expressed in the dorsal margin of the presumptive eye field, ahead of the morphogenetic furrow. We have shown that inactivation of Wingless results in the induction of an ectopic furrow that proceeds ventrally from the dorsal margin. This ectopic furrow is normal in most respects, however the clusters formed by it fail to rotate, and we propose a two-vector model to account for normal rotation and tissue polarity in the retina. A second consequence of this inactivation of Wingless is that the dorsal head is largely deleted. We have also found that patched loss-of-function mosaic clones induce circular ectopic morphogenetic furrows (consistent with the observations of other workers with the hedgehog, and PKA genes). We use such patched induced furrows to test the two-vector model for cluster rotation and tissue polarity.
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A Tomlinson, W. Strapps, and J Heemskerk Linking Frizzled and Wnt signaling in Drosophila development Development, January 11, 1997; 124(22): 4515 - 4521. [Abstract] [PDF]
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T. Heslip, H Theisen, H Walker, and J. Marsh Shaggy and dishevelled exert opposite effects on Wingless and Decapentaplegic expression and on positional identity in imaginal discs Development, January 3, 1997; 124(5): 1069 - 1078. [Abstract] [PDF]
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W Shen and G Mardon Ectopic eye development in Drosophila induced by directed dachshund expression Development, January 1, 1997; 124(1): 45 - 52. [Abstract] [PDF]
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F Pignoni and S. Zipursky Induction of Drosophila eye development by decapentaplegic Development, January 1, 1997; 124(2): 271 - 278. [Abstract] [PDF]
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F Chanut and U Heberlein Role of decapentaplegic in initiation and progression of the morphogenetic furrow in the developing Drosophila retina Development, January 1, 1997; 124(2): 559 - 567. [Abstract] [PDF]
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V. Wiersdorff, T. Lecuit, S. M. Cohen, and M. Mlodzik Mad acts downstream of Dpp receptors, revealing a differential requirement for dpp signaling in initiation and propagation of morphogenesis in the Drosophila eye Development, July 1, 1996; 122(7): 2153 - 2162. [Abstract] [PDF]
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H Theisen, T. Haerry, M. O'Connor, and J. Marsh Developmental territories created by mutual antagonism between Wingless and Decapentaplegic Development, January 12, 1996; 122(12): 3939 - 3948. [Abstract] [PDF]
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J Harris, L Honigberg, N Robinson, and C Kenyon Neuronal cell migration in C. elegans: regulation of Hox gene expression and cell position Development, January 10, 1996; 122(10): 3117 - 3131. [Abstract] [PDF]
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K. Cadigan and R Nusse wingless signaling in the Drosophila eye and embryonic epidermis Development, January 9, 1996; 122(9): 2801 - 2812. [Abstract] [PDF]
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J Royet and R Finkelstein hedgehog, wingless and orthodenticle specify adult head development in Drosophila Development, January 6, 1996; 122(6): 1849 - 1858. [Abstract] [PDF]
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F Chanut and U Heberlein Role of the morphogenetic furrow in establishing polarity in the Drosophila eye Development, January 12, 1995; 121(12): 4085 - 4094. [Abstract] [PDF]
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D. Strutt and M Mlodzik Ommatidial polarity in the Drosophila eye is determined by the direction of furrow progression and local interactions Development, January 12, 1995; 121(12): 4247 - 4256. [Abstract] [PDF]
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