|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 121, Issue 8 2537-2547, Copyright © 1995 by Company of Biologists
JOURNAL ARTICLES |
E Marti, R Takada, DA Bumcrot, H Sasaki and AP McMahon
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
Sonic hedgehog (Shh) encodes a signal that is implicated in both short- and long-range interactions that pattern the vertebrate central nervous system (CNS), somite and limb. Studies in vitro indicate that Shh protein undergoes an internal cleavage to generate two secreted peptides. We have investigated the distribution of Shh peptides with respect to these patterning events using peptide-specific antibodies. Immunostaining of chick and mouse embryos indicates that Shh peptides are expressed in the notochord, floor plate and posterior mesenchyme of the limb at the appropriate times for their postulated patterning functions. The amino peptide that is implicated in intercellular signaling is secreted but remains tightly associated with expressing cells. The distribution of peptides in the ventral CNS is polarized with the highest levels of protein accumulating towards the luminal surface. Interestingly, Shh expression extends beyond the floor plate, into ventrolateral regions from which some motor neuron precursors are emerging. In the limb bud, peptides are restricted to a small region of posterior-distal mesenchyme in close association with the apical ectodermal ridge; a region that extends 50-75 microns along the anterior-posterior axis. Temporal expression of Shh peptides is consistent with induction of sclerotome in somites and floor plate and motor neurons in the CNS, as well as the regulation of anterior-posterior polarity in the limb. However, we can find no direct evidence for long-range diffusion of the 19 x 10(3) Mr peptide which is thought to mediate both short- and long-range cell interactions. Thus, either long-range signaling is mediated indirectly by the activation of other signals, or alternatively the low levels of diffusing peptide are undetectable using available techniques.
This article has been cited by other articles:
|
|
 |
|
  M. Varjosalo and J. Taipale Hedgehog: functions and mechanisms Genes & Dev., September 15, 2008; 22(18): 2454 - 2472. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Dessaud, A. P. McMahon, and J. Briscoe Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network Development, August 1, 2008; 135(15): 2489 - 2503. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Nakaya, H.-S. Lee, Y. Takada, I. Tzchori, and S. I. Tomarev Zebrafish Olfactomedin 1 Regulates Retinal Axon Elongation In Vivo and Is a Modulator of Wnt Signaling Pathway J. Neurosci., July 30, 2008; 28(31): 7900 - 7910. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Garcia-Campmany and E. Marti The TGF{beta} intracellular effector Smad3 regulates neuronal differentiation and cell fate specification in the developing spinal cord Development, January 1, 2007; 134(1): 65 - 75. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. Kim and G. Lemke Hedgehog-regulated localization of Vax2 controls eye development. Genes & Dev., October 15, 2006; 20(20): 2833 - 2847. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Zhu, S. Guthrie, and F. Murakami Ephrin A/EphA controls the rostral turning polarity of a lateral commissural tract in chick hindbrain. Development, October 1, 2006; 133(19): 3837 - 3846. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Fotaki, T. Yu, P. A. Zaki, J. O. Mason, and D. J. Price Abnormal Positioning of Diencephalic Cell Types in Neocortical Tissue in the Dorsal Telencephalon of Mice Lacking Functional Gli3 J. Neurosci., September 6, 2006; 26(36): 9282 - 9292. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A Woollett Maternal cholesterol in fetal development: transport of cholesterol from the maternal to the fetal circulation Am. J. Clinical Nutrition, December 1, 2005; 82(6): 1155 - 1161. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Ohyama, P. Ellis, S. Kimura, and M. Placzek Directed differentiation of neural cells to hypothalamic dopaminergic neurons Development, December 1, 2005; 132(23): 5185 - 5197. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A.-M. Marzesco, P. Janich, M. Wilsch-Brauninger, V. Dubreuil, K. Langenfeld, D. Corbeil, and W. B. Huttner Release of extracellular membrane particles carrying the stem cell marker prominin-1 (CD133) from neural progenitors and other epithelial cells J. Cell Sci., July 1, 2005; 118(13): 2849 - 2858. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. S. Lindegaard, J. E. Nielsen, J. Hannibal, and L. B. Nielsen Expression of the endothelial lipase gene in murine embryos and reproductive organs J. Lipid Res., March 1, 2005; 46(3): 439 - 444. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Feng, B. White, O. V. Tyurina, B. Guner, T. Larson, H. Y. Lee, R. O. Karlstrom, and J. D. Kohtz Synergistic and antagonistic roles of the Sonic hedgehog N- and C-terminal lipids Development, September 1, 2004; 131(17): 4357 - 4370. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Gulacsi and L. Lillien Sonic Hedgehog and Bone Morphogenetic Protein Regulate Interneuron Development from Dorsal Telencephalic Progenitors In Vitro J. Neurosci., October 29, 2003; 23(30): 9862 - 9872. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. D. Sacks, G. M. Cann, W. Nikovits Jr, S. Conlon, N. R. Espinoza, and F. E. Stockdale Regulation of myosin expression during myotome formation Development, August 1, 2003; 130(15): 3391 - 3402. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. D. Dakubo, Y. P. Wang, C. Mazerolle, K. Campsall, A. P. McMahon, and V. A. Wallace Retinal ganglion cell-derived sonic hedgehog signaling is required for optic disc and stalk neuroepithelial cell development Development, July 1, 2003; 130(13): 2967 - 2980. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. McCarthy and W. S. Argraves Megalin and the neurodevelopmental biology of sonic hedgehog and retinol J. Cell Sci., March 15, 2003; 116(6): 955 - 960. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kawakami, T'N. Kawcak, Y.-J. Li, W. Zhang, Y. Hu, and P.-T. Chuang Mouse dispatched mutants fail to distribute hedgehog proteins and are defective in hedgehog signaling Development, March 14, 2003; 129(24): 5753 - 5765. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Agarwala and C. W. Ragsdale A role for midbrain arcs in nucleogenesis Development, March 14, 2003; 129(24): 5779 - 5788. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-B. Charrier, F. Lapointe, N. M. Le Douarin, and M.-A. Teillet Dual origin of the floor plate in the avian embryo Development, March 12, 2003; 129(20): 4785 - 4796. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Sanders, A. Lumsden, and C. W. Ragsdale Arcuate Plan of Chick Midbrain Development J. Neurosci., December 15, 2002; 22(24): 10742 - 10750. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Huang, H. Roelink, and G. S. McKnight Protein Kinase A Deficiency Causes Axially Localized Neural Tube Defects in Mice J. Biol. Chem., May 24, 2002; 277(22): 19889 - 19896. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Gritli-Linde, M. Bei, R. Maas, X. M. Zhang, A. Linde, and A. P. McMahon Shh signaling within the dental epithelium is necessary for cell proliferation, growth and polarization Development, January 12, 2002; 129(23): 5323 - 5337. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Rathjen, B. P. Haines, K. M. Hudson, A. Nesci, S. Dunn, and P. D. Rathjen Directed differentiation of pluripotent cells to neural lineages: homogeneous formation and differentiation of a neurectoderm population Development, January 6, 2002; 129(11): 2649 - 2661. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. W. Yip, P. Ferretti, and A. J. Copp Heparan sulphate proteoglycans and spinal neurulation in the mouse embryo Development, January 5, 2002; 129(9): 2109 - 2119. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Trousse, E. Marti, P. Gruss, M. Torres, and P. Bovolenta Control of retinal ganglion cell axon growth: a new role for Sonic hedgehog Development, October 15, 2001; 128(20): 3927 - 3936. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-B. Charrier, F. Lapointe, N. M. L. Douarin, and M.-A. Teillet Anti-apoptotic role of Sonic hedgehog protein at the early stages of nervous system organogenesis Development, October 15, 2001; 128(20): 4011 - 4020. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S Pons, J. Trejo, J. Martinez-Morales, and E Marti Vitronectin regulates Sonic hedgehog activity during cerebellum development through CREB phosphorylation Development, January 5, 2001; 128(9): 1481 - 1492. [Abstract] [PDF]
|
|
|
|
|
|
Y Lin, S Zhang, M Rehn, P Itaranta, J Tuukkanen, R Heljasvaara, H Peltoketo, T Pihlajaniemi, and S Vainio Induced repatterning of type XVIII collagen expression in ureter bud from kidney to lung type: association with sonic hedgehog and ectopic surfactant protein C Development, January 5, 2001; 128(9): 1573 - 1585. [Abstract] [PDF]
|
|
|
|
|
|
G Deutsch, J Jung, M Zheng, J Lora, and K. Zaret A bipotential precursor population for pancreas and liver within the embryonic endoderm Development, January 3, 2001; 128(6): 871 - 881. [Abstract] [PDF]
|
|
|
|
 |
|
 R. K. Guy Inhibition of sonic hedgehog autoprocessing in cultured mammalian cells by sterol deprivation PNAS, June 20, 2000; 97(13): 7307 - 7312. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Roux, C. Wolf, N. Mulliez, W. Gaoua, V. Cormier, F. Chevy, and D. Citadelle Role of cholesterol in embryonic development Am. J. Clinical Nutrition, May 1, 2000; 71(5): 1270S - 1279. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Gerrish, M. Gannon, D. Shih, E. Henderson, M. Stoffel, C. V. E. Wright, and R. Stein Pancreatic beta Cell-specific Transcription of the pdx-1 Gene. THE ROLE OF CONSERVED UPSTREAM CONTROL REGIONS AND THEIR HEPATIC NUCLEAR FACTOR 3beta SITES J. Biol. Chem., February 4, 2000; 275(5): 3485 - 3492. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D Summerbell, P. Ashby, O Coutelle, D Cox, S Yee, and P. Rigby The expression of Myf5 in the developing mouse embryo is controlled by discrete and dispersed enhancers specific for particular populations of skeletal muscle precursors Development, January 9, 2000; 127(17): 3745 - 3757. [Abstract] [PDF]
|
|
|
|
|
|
G Drossopoulou, K. Lewis, J. Sanz-Ezquerro, N Nikbakht, A. McMahon, C Hofmann, and C Tickle A model for anteroposterior patterning of the vertebrate limb based on sequential long- and short-range Shh signalling and Bmp signalling Development, January 4, 2000; 127(7): 1337 - 1348. [Abstract] [PDF]
|
|
|
|
|
|
S Pons and E Marti Sonic hedgehog synergizes with the extracellular matrix protein vitronectin to induce spinal motor neuron differentiation Development, January 1, 2000; 127(2): 333 - 342. [Abstract] [PDF]
|
|
|
|
|
|
D. H. Rowitch, B. St.-Jacques, S. M. K. Lee, J. D. Flax, E. Y. Snyder, and A. P. McMahon Sonic hedgehog Regulates Proliferation and Inhibits Differentiation of CNS Precursor Cells J. Neurosci., October 15, 1999; 19(20): 8954 - 8965. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Dutton, T. Yamada, A. Turnley, P. F. Bartlett, and M. Murphy Sonic Hedgehog Promotes Neuronal Differentiation of Murine Spinal Cord Precursors and Collaborates with Neurotrophin 3 to Induce Islet-1 J. Neurosci., April 1, 1999; 19(7): 2601 - 2608. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D Hu and J. Helms The role of sonic hedgehog in normal and abnormal craniofacial morphogenesis Development, January 11, 1999; 126(21): 4873 - 4884. [Abstract] [PDF]
|
|
|
|
|
|
H Sasaki, Y Nishizaki, C Hui, M Nakafuku, and H Kondoh Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling Development, January 9, 1999; 126(17): 3915 - 3924. [Abstract] [PDF]
|
|
|
|
|
|
D. Orentas, J. Hayes, K. Dyer, and R. Miller Sonic hedgehog signaling is required during the appearance of spinal cord oligodendrocyte precursors Development, January 6, 1999; 126(11): 2419 - 2429. [Abstract] [PDF]
|
|
|
|
|
|
H Nishina, C Vaz, P Billia, M Nghiem, T Sasaki, J. De la Pompa, K Furlonger, C Paige, C Hui, K. Fischer, et al. Defective liver formation and liver cell apoptosis in mice lacking the stress signaling kinase SEK1/MKK4 Development, January 2, 1999; 126(3): 505 - 516. [Abstract] [PDF]
|
|
|
|
|
|
F Pituello, F Medevielle, F Foulquier, and A. Duprat Activation of Pax6 depends on somitogenesis in the chick embryo cervical spinal cord Development, January 2, 1999; 126(3): 587 - 596. [Abstract] [PDF]
|
|
|
|
|
|
H Amthor, B Christ, and K Patel A molecular mechanism enabling continuous embryonic muscle growth - a balance between proliferation and differentiation Development, January 2, 1999; 126(5): 1041 - 1053. [Abstract] [PDF]
|
|
|
|
|
|
D. Epstein, A. McMahon, and A. Joyner Regionalization of Sonic hedgehog transcription along the anteroposterior axis of the mouse central nervous system is regulated by Hnf3-dependent and -independent mechanisms Development, January 1, 1999; 126(2): 281 - 292. [Abstract] [PDF]
|
|
|
|
|
|
K Dale, N Sattar, J Heemskerk, J. Clarke, M Placzek, and J Dodd Differential patterning of ventral midline cells by axial mesoderm is regulated by BMP7 and chordin Development, January 1, 1999; 126(2): 397 - 408. [Abstract] [PDF]
|
|
|
|
|
|
M.-A. Teillet, F. Lapointe, and N. M. Le Douarin The relationships between notochord and floor plate in vertebrate development revisited PNAS, September 29, 1998; 95(20): 11733 - 11738. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. K. Cooper, J. A. Porter, K. E. Young, and P. A. Beachy Teratogen-Mediated Inhibition of Target Tissue Response to Shh Signaling Science, June 5, 1998; 280(5369): 1603 - 1607. [Abstract] [Full Text]
|
|
|
|
|
|
M. Selleck, M. Garcia-Castro, K. Artinger, and M Bronner-Fraser Effects of Shh and Noggin on neural crest formation demonstrate that BMP is required in the neural tube but not ectoderm Development, January 12, 1998; 125(24): 4919 - 4930. [Abstract] [PDF]
|
|
|
|
|
|
J. Kohtz, D. Baker, G Corte, and G Fishell Regionalization within the mammalian telencephalon is mediated by changes in responsiveness to Sonic Hedgehog Development, January 12, 1998; 125(24): 5079 - 5089. [Abstract] [PDF]
|
|
|
|
|
|
M. Matise, D. Epstein, H. Park, K. Platt, and A. Joyner Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system Development, January 8, 1998; 125(15): 2759 - 2770. [Abstract] [PDF]
|
|
|
|
|
|
Q Ding, J Motoyama, S Gasca, R Mo, H Sasaki, J Rossant, and C. Hui Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice Development, January 7, 1998; 125(14): 2533 - 2543. [Abstract] [PDF]
|
|
|
|
|
|
M Teillet, Y Watanabe, P Jeffs, D Duprez, F Lapointe, and N. Le Douarin Sonic hedgehog is required for survival of both myogenic and chondrogenic somitic lineages Development, January 6, 1998; 125(11): 2019 - 2030. [Abstract] [PDF]
|
|
|
|
|
|
J. Dockter and C. Ordahl Determination of sclerotome to the cartilage fate Development, January 6, 1998; 125(11): 2113 - 2124. [Abstract] [PDF]
|
|
|
|
|
|
H. Kim, D. Rice, P. Kettunen, and I Thesleff FGF-, BMP- and Shh-mediated signalling pathways in the regulation of cranial suture morphogenesis and calvarial bone development Development, January 4, 1998; 125(7): 1241 - 1251. [Abstract] [PDF]
|
|
|
|
|
|
R Tuttle, J. Braisted, L. Richards, and D. O'Leary Retinal axon guidance by region-specific cues in diencephalon Development, January 3, 1998; 125(5): 791 - 801. [Abstract] [PDF]
|
|
|
|
|
|
R. Shirasaki, R. Katsumata, and F. Murakami Change in Chemoattractant Responsiveness of Developing Axons at an Intermediate Target Science, January 2, 1998; 279(5347): 105 - 107. [Abstract] [Full Text]
|
|
|
|
|
|
C Hayes, J. Brown, M. Lyon, and G. Morriss-Kay Sonic hedgehog is not required for polarising activity in the Doublefoot mutant mouse limb bud Development, January 2, 1998; 125(3): 351 - 357. [Abstract] [PDF]
|
|
|
|
|
|
D Duprez, C Fournier-Thibault, and N Le Douarin Sonic Hedgehog induces proliferation of committed skeletal muscle cells in the chick limb Development, January 2, 1998; 125(3): 495 - 505. [Abstract] [PDF]
|
|
|
|
|
|
A. Borycki, L Mendham, and C. Emerson Control of somite patterning by Sonic hedgehog and its downstream signal response genes Development, January 2, 1998; 125(4): 777 - 790. [Abstract] [PDF]
|
|
|
|
 |
|
 K.M. Weiss, D.W. Stock, and Z. Zhao Dynamic Interactions and the Evolutionary Genetics of Dental Patterning Critical Reviews in Oral Biology & Medicine, January 1, 1998; 9(4): 369 - 398. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. Blagden, P. D. Currie, P. W. Ingham, and S. M. Hughes Notochord induction of zebrafish slow muscle mediated by Sonic hedgehog Genes & Dev., September 1, 1997; 11(17): 2163 - 2175. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Miao, M. Wang, J. A. Ott, J. S. D'Alessandro, T. M. Woolf, D. A. Bumcrot, N. K. Mahanthappa, and K. Pang Sonic Hedgehog Promotes the Survival of Specific CNS Neuron Populations and Protects These Cells from Toxic Insult In Vitro J. Neurosci., August 1, 1997; 17(15): 5891 - 5899. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Murakami, A. Nifuji, and M. Noda Expression of Indian Hedgehog in Osteoblasts and Its Posttranscriptional Regulation by Transforming Growth Factor-{beta} Endocrinology, May 1, 1997; 138(5): 1972 - 1978. [Abstract] [Full Text] [PDF]
|
|
