|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 121, Issue 8 2583-2594, Copyright © 1995 by Company of Biologists
JOURNAL ARTICLES |
G Brill, N Kahane, C Carmeli, D von Schack, YA Barde and C Kalcheim
Department of Anatomy and Embryology, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Development of the somite-derived dermatome involves conversion of the epithelial dermatome progenitors into mesenchymal cells of the dermis. In chick embryos, neural tube-derived signals are required for this conversion, as the interposition of a membrane between neural tube and somites results in a failure of the dermatome to lose its epithelial arrangement. However, dermis formation can be completely rescued by coating the membranes with Neurotrophin-3, but not with the related molecule Nerve growth factor. Neurotrophin-3 was also found to be necessary for dermatome dissociation using in vitro explants or partially dissociated dermomyotomes. The functional relevance of these observations was investigated by neutralizing endogenous Neurotrophin-3 using a specific blocking antibody. Antibody-treated embryos revealed the presence of tightly aggregated cells between myotome and ectoderm instead of the loose dermal mesenchyme observed in embryos treated with control antibodies. As previous studies have demonstrated the presence of Neurotrophin-3 in the neural tube, these results suggest that it may be a necessary neural tube-derived signal required for early stages of dermis formation.
This article has been cited by other articles:
|
|
 |
|
  K. Gassei, J. Ehmcke, and S. Schlatt Initiation of testicular tubulogenesis is controlled by neurotrophic tyrosine receptor kinases in a three-dimensional Sertoli cell aggregation assay Reproduction, October 1, 2008; 136(4): 459 - 469. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Linker, C. Lesbros, J. Gros, L. W. Burrus, A. Rawls, and C. Marcelle {beta}-Catenin-dependent Wnt signalling controls the epithelial organisation of somites through the activation of paraxis Development, September 1, 2005; 132(17): 3895 - 3905. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Ben-Yair and C. Kalcheim Lineage analysis of the avian dermomyotome sheet reveals the existence of single cells with both dermal and muscle progenitor fates Development, February 15, 2005; 132(4): 689 - 701. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Hogan, C. A. Ambler, D. L. Chapman, and V. L. Bautch The neural tube patterns vessels developmentally using the VEGF signaling pathway Development, April 1, 2004; 131(7): 1503 - 1513. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Olivera-Martinez, S. Missier, S. Fraboulet, J. Thelu, and D. Dhouailly Differential regulation of the chick dorsal thoracic dermal progenitors from the medial dermomyotome Development, March 12, 2003; 129(20): 4763 - 4772. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Kahane, Y. Cinnamon, I. Bachelet, and C. Kalcheim The third wave of myotome colonization by mitotically competent progenitors: regulating the balance between differentiation and proliferation during muscle development Development, June 15, 2001; 128(12): 2187 - 2198. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y Cinnamon, N Kahane, I Bachelet, and C Kalcheim The sub-lip domain--a distinct pathway for myotome precursors that demonstrate rostral-caudal migration Development, January 2, 2001; 128(3): 341 - 351. [Abstract] [PDF]
|
|
|
|
|
|
D. Houzelstein, Y. Cheraud, G. Auda-Boucher, J. Fontaine-Perus, and B. Robert The expression of the homeobox gene Msx1 reveals two populations of dermal progenitor cells originating from the somites Development, May 15, 2000; 127(10): 2155 - 2164. [Abstract] [PDF]
|
|
|
|
|
|
D Sela-Donenfeld and C Kalcheim Inhibition of noggin expression in the dorsal neural tube by somitogenesis: a mechanism for coordinating the timing of neural crest emigration Development, January 11, 2000; 127(22): 4845 - 4854. [Abstract] [PDF]
|
|
|
|
|
|
W. Denetclaw and C. Ordahl The growth of the dermomyotome and formation of early myotome lineages in thoracolumbar somites of chicken embryos Development, January 2, 2000; 127(4): 893 - 905. [Abstract] [PDF]
|
|
|
|
 |
|
 E. Levine, A. S. Cupp, and M. K. Skinner Role of Neurotropins in Rat Embryonic Testis Morphogenesis (Cord Formation) Biol Reprod, January 1, 2000; 62(1): 132 - 142. [Abstract] [Full Text]
|
|
|
|
 |
|
 C. Meier, E. Parmantier, A. Brennan, R. Mirsky, and K. R. Jessen Developing Schwann Cells Acquire the Ability to Survive without Axons by Establishing an Autocrine Circuit Involving Insulin-Like Growth Factor, Neurotrophin-3, and Platelet-Derived Growth Factor-BB J. Neurosci., May 15, 1999; 19(10): 3847 - 3859. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y Cinnamon, N Kahane, and C Kalcheim Characterization of the early development of specific hypaxial muscles from the ventrolateral myotome Development, January 10, 1999; 126(19): 4305 - 4315. [Abstract] [PDF]
|
|
|
|
|
|
N Kahane, Y Cinnamon, and C Kalcheim The cellular mechanism by which the dermomyotome contributes to the second wave of myotome development Development, January 11, 1998; 125(21): 4259 - 4271. [Abstract] [PDF]
|
|
|
|
|
|
S Dietrich, F. Schubert, C Healy, P. Sharpe, and A Lumsden Specification of the hypaxial musculature Development, January 6, 1998; 125(12): 2235 - 2249. [Abstract] [PDF]
|
|
|
|
|
|
Z. Z. Liu, L. Q. Zhu, and F. F. Eide Critical Role of TrkB and Brain-Derived Neurotrophic Factor in the Differentiation and Survival of Retinal Pigment Epithelium J. Neurosci., November 15, 1997; 17(22): 8749 - 8755. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S Dietrich, F. Schubert, and A Lumsden Control of dorsoventral pattern in the chick paraxial mesoderm Development, January 10, 1997; 124(19): 3895 - 3908. [Abstract] [PDF]
|
|
|
|
|
|
F. A. White, I. Silos-Santiago, D. C. Molliver, M. Nishimura, H. Phillips, M. Barbacid, and W. D. Snider Synchronous Onset of NGF and TrkA Survival Dependence in Developing Dorsal Root Ganglia J. Neurosci., August 1, 1996; 16(15): 4662 - 4672. [Abstract] [Full Text] [PDF]
|
|
