|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 122, Issue 10 3117-3131, Copyright © 1996 by Company of Biologists
JOURNAL ARTICLES |
J Harris, L Honigberg, N Robinson and C Kenyon
Department of Biochemistry and Biophysics, University of California, San Francisco 94143-0554, USA.
In C. elegans, the Hox gene mab-5, which specifies the fates of cells in the posterior body region, has been shown to direct the migrations of certain cells within its domain of function. mab-5 expression switches on in the neuroblast QL as it migrates into the posterior body region. mab-5 activity is then required for the descendants of QL to migrate to posterior rather than anterior positions. What information activates Hox gene expression during this cell migration? How are these cells subsequently guided to their final positions? We address these questions by describing four genes, egl-20, mig-14, mig-1 and lin-17, that are required to activate expression of mab-5 during migration of the QL neuroblast. We find that two of these genes, egl-20 and mig-14, also act in a mab-5-independent way to determine the final stopping points of the migrating Q descendants. The Q descendants do not migrate toward any obvious physical targets in wild-type or mutant animals. Therefore, these genes appear to be part of a system that positions the migrating Q descendants along the anteroposterior axis.
This article has been cited by other articles:
|
|
 |
|
  A. Y. Zinovyeva, Y. Yamamoto, H. Sawa, and W. C. Forrester Complex Network of Wnt Signaling Regulates Neuronal Migrations During Caenorhabditis elegans Development Genetics, July 1, 2008; 179(3): 1357 - 1371. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Green, T. Inoue, and P. W. Sternberg The C. elegans ROR receptor tyrosine kinase, CAM-1, non-autonomously inhibits the Wnt pathway Development, November 15, 2007; 134(22): 4053 - 4062. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Kee, B. J. Hwang, P. W. Sternberg, and M. Bronner-Fraser Evolutionary conservation of cell migration genes: from nematode neurons to vertebrate neural crest Genes & Dev., February 15, 2007; 21(4): 391 - 396. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Coudreuse and H. C. Korswagen The making of Wnt: new insights into Wnt maturation, sorting and secretion Development, January 1, 2007; 134(1): 3 - 12. [Full Text] [PDF]
|
|
|
|
 |
|
 D. Y. M. Coudreuse, G. Roel, M. C. Betist, O. Destree, and H. C. Korswagen Wnt Gradient Formation Requires Retromer Function in Wnt-Producing Cells Science, May 12, 2006; 312(5775): 921 - 924. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. C. Prasad and S. G. Clark Wnt signaling establishes anteroposterior neuronal polarity and requires retromer in C. elegans Development, May 1, 2006; 133(9): 1757 - 1766. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. G. Fradkin, G. Garriga, P. C. Salinas, J. B. Thomas, X. Yu, and Y. Zou Wnt Signaling in Neural Circuit Development J. Neurosci., November 9, 2005; 25(45): 10376 - 10378. [Full Text] [PDF]
|
|
|
|
|
|
L. Yang, M. Sym, and C. Kenyon The roles of two C. elegans HOX co-factor orthologs in cell migration and vulva development Development, March 15, 2005; 132(6): 1413 - 1428. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-F. Chuang and C. I. Bargmann A Toll-interleukin 1 repeat protein at the synapse specifies asymmetric odorant receptor expression via ASK1 MAPKKK signaling Genes & Dev., January 15, 2005; 19(2): 270 - 281. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. C. Forrester, C. Kim, and G. Garriga The Caenorhabditis elegans Ror RTK CAM-1 Inhibits EGL-20/Wnt Signaling in Cell Migration Genetics, December 1, 2004; 168(4): 1951 - 1962. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Syntichaki and N. Tavernarakis Genetic Models of Mechanotransduction: The Nematode Caenorhabditis elegans Physiol Rev, October 1, 2004; 84(4): 1097 - 1153. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Ch'ng, L. Williams, Y. S. Lie, M. Sym, J. Whangbo, and C. Kenyon Identification of Genes That Regulate a Left-Right Asymmetric Neuronal Migration in Caenorhabditis elegans Genetics, August 1, 2003; 164(4): 1355 - 1367. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Gleason, H. C. Korswagen, and D. M. Eisenmann Activation of Wnt signaling bypasses the requirement for RTK/Ras signaling during C. elegans vulval induction Genes & Dev., May 15, 2002; 16(10): 1281 - 1290. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. C. Korswagen, D. Y.M. Coudreuse, M. C. Betist, S. van de Water, D. Zivkovic, and H. C. Clevers The Axin-like protein PRY-1 is a negative regulator of a canonical Wnt pathway in C. elegans Genes & Dev., May 15, 2002; 16(10): 1291 - 1302. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Natarajan, N. E. Witwer, and D. M. Eisenmann The Divergent Caenorhabditis elegans {beta}-Catenin Proteins BAR-1, WRM-1 and HMP-2 Make Distinct Protein Interactions but Retain Functional Redundancy in Vivo Genetics, September 1, 2001; 159(1): 159 - 172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Du and M. Chalfie Genes Regulating Touch Cell Development in Caenorhabditis elegans Genetics, May 1, 2001; 158(1): 197 - 207. [Abstract] [Full Text]
|
|
|
|
|
|
M Herman C. elegans POP-1/TCF functions in a canonical Wnt pathway that controls cell migration and in a noncanonical Wnt pathway that controls cell polarity Development, January 2, 2001; 128(4): 581 - 590. [Abstract] [PDF]
|
|
|
|
|
|
D. M. Eisenmann and S. K. Kim Protruding Vulva Mutants Identify Novel Loci and Wnt Signaling Factors That Function During Caenorhabditis elegans Vulva Development Genetics, November 1, 2000; 156(3): 1097 - 1116. [Abstract] [Full Text]
|
|
|
|
|
|
J Whangbo, J Harris, and C Kenyon Multiple levels of regulation specify the polarity of an asymmetric cell division in C. elegans Development, January 11, 2000; 127(21): 4587 - 4598. [Abstract] [PDF]
|
|
|
|
|
|
L Honigberg and C Kenyon Establishment of left/right asymmetry in neuroblast migration by UNC-40/DCC, UNC-73/Trio and DPY-19 proteins in C. elegans Development, January 11, 2000; 127(21): 4655 - 4668. [Abstract] [PDF]
|
|
|
|
|
|
N Pujol, P Torregrossa, J. Ewbank, and J. Brunet The homeodomain protein CePHOX2/CEH-17 controls antero-posterior axonal growth in C. elegans Development, January 8, 2000; 127(15): 3361 - 3371. [Abstract] [PDF]
|
|
|
|
|
|
M. Halloran, M Sato-Maeda, J. Warren, F Su, Z Lele, P. Krone, J. Kuwada, and W Shoji Laser-induced gene expression in specific cells of transgenic zebrafish Development, January 5, 2000; 127(9): 1953 - 1960. [Abstract] [PDF]
|
|
|
|
|
|
S Sumanas, P Strege, J Heasman, and S. Ekker The putative wnt receptor Xenopus frizzled-7 functions upstream of beta-catenin in vertebrate dorsoventral mesoderm patterning Development, January 5, 2000; 127(9): 1981 - 1990. [Abstract] [PDF]
|
|
|
|
|
|
K. Nishiwaki Mutations Affecting Symmetrical Migration of Distal Tip Cells in Caenorhabditis elegans Genetics, July 1, 1999; 152(3): 985 - 997. [Abstract] [Full Text]
|
|
|
|
|
|
P Bhanot, M Fish, J. Jemison, R Nusse, J Nathans, and K. Cadigan Frizzled and Dfrizzled-2 function as redundant receptors for Wingless during Drosophila embryonic development Development, January 9, 1999; 126(18): 4175 - 4186. [Abstract] [PDF]
|
|
|
|
|
|
D. Montell The genetics of cell migration in Drosophila melanogaster and Caenorhabditis elegans development Development, January 6, 1999; 126(14): 3035 - 3046. [Abstract] [PDF]
|
|
|
|
|
|
Y Liu and D. Montell Identification of mutations that cause cell migration defects in mosaic clones Development, January 5, 1999; 126(9): 1869 - 1878. [Abstract] [PDF]
|
|
|
|
|
|
C. Hunter, J. Harris, J. Maloof, and C Kenyon Hox gene expression in a single Caenorhabditis elegans cell is regulated by a caudal homolog and intercellular signals that inhibit wnt signaling Development, January 2, 1999; 126(4): 805 - 814. [Abstract] [PDF]
|
|
|
|
|
|
M. Herman, Q Ch'ng, S. Hettenbach, T. Ratliff, C Kenyon, and R. Herman EGL-27 is similar to a metastasis-associated factor and controls cell polarity and cell migration in C. elegans Development, January 2, 1999; 126(5): 1055 - 1064. [Abstract] [PDF]
|
|
|
|
|
|
J. Maloof, J Whangbo, J. Harris, G. Jongeward, and C Kenyon A Wnt signaling pathway controls hox gene expression and neuroblast migration in C. elegans Development, January 1, 1999; 126(1): 37 - 49. [Abstract] [PDF]
|
|
|
|
|
|
K. M. Kozopas, C. H. Samos, and R. Nusse DWnt-2, a Drosophila Wnt gene required for the development of the male reproductive tract, specifies a sexually dimorphic cell fate Genes & Dev., April 15, 1998; 12(8): 1155 - 1165. [Abstract] [Full Text]
|
|
|
|
|
|
A Nasevicius, T Hyatt, H Kim, J Guttman, E Walsh, S Sumanas, Y Wang, and S. Ekker Evidence for a frizzled-mediated wnt pathway required for zebrafish dorsal mesoderm formation Development, January 11, 1998; 125(21): 4283 - 4292. [Abstract] [PDF]
|
|
|
|
|
|
M. Deardorff, C Tan, L. Conrad, and P. Klein Frizzled-8 is expressed in the Spemann organizer and plays a role in early morphogenesis Development, January 7, 1998; 125(14): 2687 - 2700. [Abstract] [PDF]
|
|
|
|
|
|
L. Jiang and P. Sternberg Interactions of EGF, Wnt and HOM-C genes specify the P12 neuroectoblast fate in C. elegans Development, January 6, 1998; 125(12): 2337 - 2347. [Abstract] [PDF]
|
|
|
|
|
|
K. M. Cadigan and R. Nusse Wnt signaling: a common theme in animal development Genes & Dev., December 15, 1997; 11(24): 3286 - 3305. [Full Text] [PDF]
|
|
|
|
 |
|
 M. S. Halfon, H. Kose, A. Chiba, and H. Keshishian Targeted gene expression without a tissue-specific promoter: Creating mosaic embryos using laser-induced single-cell heat shock PNAS, June 10, 1997; 94(12): 6255 - 6260. [Abstract] [Full Text] [PDF]
|
|
