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Development, Vol 122, Issue 10 3275-3282, Copyright © 1996 by Company of Biologists
JOURNAL ARTICLES |
KD Lustig, K Kroll, E Sun, R Ramos, H Elmendorf and MW Kirschner
Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Using a paracrine assay to screen for signaling proteins that could respecify ectodermal tissue, we isolated a Xenopus gene related to the mouse gene nodal, a member of the TGFbeta superfamily. The gene is expressed in three regions in the early Xenopus embryo: first in the gastrula organizer, then in two stripes of cells flanking the posterior notochord in late neurulae, and finally in lateral plate mesoderm restricted to the left side of tailbud-stage embryos. Ectopic expression of the gene induces muscle formation in ectodermal explants and partial secondary axes in whole embryos. Together with noggin, another secreted protein also present in the organizer, it induces notochord formation in ectodermal explants and complete secondary axes in whole embryos. These results suggest that the nodal-related gene may act together with noggin to induce axial pattern during gastrulation and also may play a role in left-right asymmetry generation in the post-gastrula embryo.
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S. Osada and C. Wright Xenopus nodal-related signaling is essential for mesendodermal patterning during early embryogenesis Development, January 6, 1999; 126(14): 3229 - 3240. [Abstract] [PDF]
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B. Bisgrove, J. Essner, and H. Yost Regulation of midline development by antagonism of lefty and nodal signaling Development, January 6, 1999; 126(14): 3253 - 3262. [Abstract] [PDF]
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B. Sun, S. Bush, L. Collins-Racie, E. LaVallie, E. DiBlasio-Smith, N. Wolfman, J. McCoy, and H. Sive derriere: a TGF-beta family member required for posterior development in Xenopus Development, January 4, 1999; 126(7): 1467 - 1482. [Abstract] [PDF]
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A Philpott, E B Porro, M W Kirschner, and L H Tsai The role of cyclin-dependent kinase 5 and a novel regulatory subunit in regulating muscle differentiation and patterning. Genes & Dev., June 1, 1997; 11(11): 1409 - 1421. [Abstract] [PDF]
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K Sampath, A. Cheng, A Frisch, and C. Wright Functional differences among Xenopus nodal-related genes in left-right axis determination Development, January 9, 1997; 124(17): 3293 - 3302. [Abstract] [PDF]
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J. Lohr, M. Danos, and H. Yost Left-right asymmetry of a nodal-related gene is regulated by dorsoanterior midline structures during Xenopus development Development, January 4, 1997; 124(8): 1465 - 1472. [Abstract] [PDF]
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K. Lustig, K. Kroll, E. Sun, and M. Kirschner Expression cloning of a Xenopus T-related gene (Xombi) involved in mesodermal patterning and blastopore lip formation Development, January 12, 1996; 122(12): 4001 - 4012. [Abstract] [PDF]
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