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Development, Vol 122, Issue 11 3677-3685, Copyright © 1996 by Company of Biologists
JOURNAL ARTICLES |
SA Wood, RR Ammann, DA Brock, L Li, T Spann and RH Gomer
Howard Hughes Medical Institute, Rice University, Houston, TX 77251-1892, USA.
In Dictyostelium, initial cell type choice is correlated with the cell-cycle phase of the cell at the time of starvation. We have isolated a mutant, ratioA (rtoA), with a defect in this mechanism that results in an abnormally high percentage of prestalk cells. The rtoA gene has been cloned and sequenced and codes for a novel protein. The cell cycle is normal in rtoA. In the wild type, prestalk cells differentiate from those cells in S or early G2 phase at starvation and prespore cells from cells in late G2 or M phase at starvation. In rtoA mutants, both prestalk and prespore cells originate randomly from cells in any phase of the cell cycle at starvation.
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