spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Carrington, E. A.
Right arrow Articles by Jones, R. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Carrington, E. A.
Right arrow Articles by Jones, R. S.

Development, Vol 122, Issue 12 4073-4083, Copyright © 1996 by Company of Biologists

JOURNAL ARTICLES

The Drosophila Enhancer of zeste gene encodes a chromosomal protein: examination of wild-type and mutant protein distribution

EA Carrington and RS Jones
Department of Biological Sciences, Southern Methodist University, Dallas, TX 75275-0376, USA.

The Drosophila Enhancer of zeste [E(z)] gene is a member of the Polycomb-group and, as such, is involved in maintaining the transcriptional repression of the homeotic genes of the Antennapedia (ANT-C) and bithorax (BX-C) complexes. It has been proposed that Polycomb-group (Pc-G)-mediated silencing requires the formation of heteromeric protein complexes which modify the chromatin structure of target genes. We describe the in vivo distribution of the E(Z) protein and show it to be ubiquitously present in embryonic and larval nuclei. In salivary gland polytenized nuclei, the identifiable E(Z) chromosome binding sites are a subset of those described for other Polycomb-group proteins, suggesting that E(Z) may also participate in Polycomb-group complexes. E(Z) binds to chromosomes in a DNA sequence-dependent manner, as illustrated by the creation of a new E(Z)-binding site at the location of a P element reporter construct that previously has been shown to contain a Polycomb response element (PRE). We also present the sequences of one null and three temperature-sensitive E(z) alleles, describe the effects these mutations have on the in vivo distribution of E(Z) protein and discuss their implications concerning putative functional domains. Finally, we describe the effect a trithorax mutation has on E(Z) chromosome binding.


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
P. Joshi, E. A. Carrington, L. Wang, C. S. Ketel, E. L. Miller, R. S. Jones, and J. A. Simon
Dominant Alleles Identify SET Domain Residues Required for Histone Methyltransferase of Polycomb Repressive Complex 2
J. Biol. Chem., October 10, 2008; 283(41): 27757 - 27766.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
U. Savla, J. Benes, J. Zhang, and R. S. Jones
Recruitment of Drosophila Polycomb-group proteins by Polycomblike, a component of a novel protein complex in larvae
Development, March 1, 2008; 135(5): 813 - 817.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
B. Bello, N. Holbro, and H. Reichert
Polycomb group genes are required for neural stem cell survival in postembryonic neurogenesis of Drosophila
Development, March 15, 2007; 134(6): 1091 - 1099.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
L. Wang, N. Jahren, M. L. Vargas, E. F. Andersen, J. Benes, J. Zhang, E. L. Miller, R. S. Jones, and J. A. Simon
Alternative ESC and ESC-Like Subunits of a Polycomb Group Histone Methyltransferase Complex Are Differentially Deployed during Drosophila Development.
Mol. Cell. Biol., April 1, 2006; 26(7): 2637 - 2647.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
C. S. Ketel, E. F. Andersen, M. L. Vargas, J. Suh, S. Strome, and J. A. Simon
Subunit Contributions to Histone Methyltransferase Activities of Fly and Worm Polycomb Group Complexes
Mol. Cell. Biol., August 15, 2005; 25(16): 6857 - 6868.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
A. Ebert, G. Schotta, S. Lein, S. Kubicek, V. Krauss, T. Jenuwein, and G. Reuter
Su(var) genes regulate the balance between euchromatin and heterochromatin in Drosophila
Genes & Dev., December 1, 2004; 18(23): 2973 - 2983.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
L. Srinivasan and M. L. Atchison
YY1 DNA binding and PcG recruitment requires CtBP
Genes & Dev., November 1, 2004; 18(21): 2596 - 2601.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
Y. Chanvivattana, A. Bishopp, D. Schubert, C. Stock, Y.-H. Moon, Z. R. Sung, and J. Goodrich
Interaction of Polycomb-group proteins controlling flowering in Arabidopsis
Development, November 1, 2004; 131(21): 5263 - 5276.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
J. Y. Ali and W. Bender
Cross-Regulation among the Polycomb Group Genes in Drosophila melanogaster
Mol. Cell. Biol., September 1, 2004; 24(17): 7737 - 7747.
[Abstract] [Full Text] [PDF]

Home page
 Cold Spring Harb Symp Quant BiolHome page
Y. ZHANG, R. CAO, L. WANG, and R.S. JONES
Mechanism of Polycomb Group Gene Silencing
Cold Spring Harb Symp Quant Biol, January 1, 2004; 69(0): 309 - 318.
[Abstract] [PDF]

Home page
 Plant Cell PhysiolHome page
T. Mayama, E. Ohtsubo, and S. Tsuchimoto
Isolation and Expression Analysis of Petunia CURLY LEAF-Like Genes
Plant Cell Physiol., August 15, 2003; 44(8): 811 - 819.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
J. Salvaing, A. Lopez, A. Boivin, J. S. Deutsch, and F. Peronnet
The Drosophila Corto protein interacts with Polycomb-group proteins and the GAGA factor
Nucleic Acids Res., June 1, 2003; 31(11): 2873 - 2882.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
F. Tie, J. Prasad-Sinha, A. Birve, A. Rasmuson-Lestander, and P. J. Harte
A 1-Megadalton ESC/E(Z) Complex from Drosophila That Contains Polycomblike and RPD3
Mol. Cell. Biol., May 1, 2003; 23(9): 3352 - 3362.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. L. Brown, C. Fritsch, J. Mueller, and J. A. Kassis
The Drosophila pho-like gene encodes a YY1-related DNA binding protein that is redundant with pleiohomeotic in homeotic gene silencing
Development, March 2, 2003; 130(2): 285 - 294.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
A. Kuzmichev, K. Nishioka, H. Erdjument-Bromage, P. Tempst, and D. Reinberg
Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein
Genes & Dev., November 15, 2002; 16(22): 2893 - 2905.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
R. Cao, L. Wang, H. Wang, L. Xia, H. Erdjument-Bromage, P. Tempst, R. S. Jones, and Y. Zhang
Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing
Science, November 1, 2002; 298(5595): 1039 - 1043.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. O'Connell, L. Wang, S. Robert, C. A. Jones, R. Saint, and R. S. Jones
Polycomblike PHD Fingers Mediate Conserved Interaction with Enhancer of Zeste Protein
J. Biol. Chem., November 9, 2001; 276(46): 43065 - 43073.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
L. Xu and S. Strome
Depletion of a Novel SET-Domain Protein Enhances the Sterility of mes-3 and mes-4 Mutants of Caenorhabditis elegans
Genetics, November 1, 2001; 159(3): 1019 - 1029.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
I. Bajusz, L. Sipos, Z. Gyorgypal, E. A. Carrington, R. S. Jones, J. Gausz, and H. Gyurkovics
The Trithorax-mimic Allele of Enhancer of zeste Renders Active Domains of Target Genes Accessible to Polycomb-Group-Dependent Silencing in Drosophila melanogaster
Genetics, November 1, 2001; 159(3): 1135 - 1150.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
R. R. Roseman, K. Morgan, D. R. Mallin, R. Roberson, T. J. Parnell, D. J. Bornemann, J. A. Simon, and P. K. Geyer
Long-Range Repression by Multiple Polycomb Group (PcG) Proteins Targeted by Fusion to a Defined DNA-Binding Domain in Drosophila
Genetics, May 1, 2001; 158(1): 291 - 307.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. Xu, Y. Fong, and S. Strome
The Caenorhabditis elegans maternal-effect sterile proteins, MES-2, MES-3, and MES-6, are associated in a complex in embryos
PNAS, April 24, 2001; 98(9): 5061 - 5066.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
H. Mabuchi, H. Fujii, G. Calin, H. Alder, M. Negrini, L. Rassenti, T. J. Kipps, F. Bullrich, and C. M. Croce
Cloning and Characterization of CLLD6, CLLD7, and CLLD8, Novel Candidate Genes for Leukemogenesis at Chromosome 13q14, a Region Commonly Deleted in B-Cell Chronic Lymphocytic Leukemia
Cancer Res., April 1, 2001; 61(7): 2870 - 2877.
[Abstract] [Full Text]

Home page
 DevelopmentHome page
D Beuchle, G Struhl, and J Muller
Polycomb group proteins and heritable silencing of Drosophila Hox genes
Development, January 3, 2001; 128(6): 993 - 1004.
[Abstract] [PDF]

Home page
 DevelopmentHome page
S Poux, D McCabe, and V Pirrotta
Recruitment of components of Polycomb Group chromatin complexes in Drosophila
Development, January 1, 2001; 128(1): 75 - 85.
[Abstract] [PDF]

Home page
 DevelopmentHome page
F Tie, T Furuyama, J Prasad-Sinha, E Jane, and P. Harte
The Drosophila Polycomb Group proteins ESC and E(Z) are present in a complex containing the histone-binding protein p55 and the histone deacetylase RPD3
Development, January 1, 2001; 128(2): 275 - 286.
[Abstract] [PDF]

Home page
 GeneticsHome page
J. J. Gildea, R. Lopez, and A. Shearn
A Screen for New Trithorax Group Genes Identified little imaginal discs, the Drosophila melanogaster Homologue of Human Retinoblastoma Binding Protein 2
Genetics, October 1, 2000; 156(2): 645 - 663.
[Abstract] [Full Text]

Home page
 DevelopmentHome page
J. Y. Song, T. Leung, L. K. Ehler, C. Wang, and Z. Liu
Regulation of meristem organization and cell division by TSO1, an Arabidopsis gene with cysteine-rich repeats
Development, May 15, 2000; 127(10): 2207 - 2217.
[Abstract] [PDF]

Home page
 DevelopmentHome page
B. A. Hauser, J. Q. He, S. O. Park, and C. S. Gasser
TSO1 is a novel protein that modulates cytokinesis and cell expansion in Arabidopsis
Development, May 15, 2000; 127(10): 2219 - 2226.
[Abstract] [PDF]

Home page
 Mol. Cell. Biol.Home page
J. Ng, C. M. Hart, K. Morgan, and J. A. Simon
A Drosophila ESC-E(Z) Protein Complex Is Distinct from Other Polycomb Group Complexes and Contains Covalently Modified ESC
Mol. Cell. Biol., May 1, 2000; 20(9): 3069 - 3078.
[Abstract] [Full Text]

Home page
 Mol. Cell. Biol.Home page
A. Breiling, E. Bonte, S. Ferrari, P. B. Becker, and R. Paro
The Drosophila Polycomb Protein Interacts with Nucleosomal Core Particles In Vitro via Its Repression Domain
Mol. Cell. Biol., December 1, 1999; 19(12): 8451 - 8460.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
G Seydoux and S Strome
Launching the germline in Caenorhabditis elegans: regulation of gene expression in early germ cells
Development, January 8, 1999; 126(15): 3275 - 3283.
[Abstract] [PDF]

Home page
 GeneticsHome page
A. Boivin and J.-M. Dura
In Vivo Chromatin Accessibility Correlates With Gene Silencing in Drosophila
Genetics, December 1, 1998; 150(4): 1539 - 1549.
[Abstract] [Full Text]

Home page
 GeneticsHome page
D. Bornemann, E. Miller, and J. Simon
Expression and Properties of Wild-Type and Mutant Forms of the Drosophila Sex Comb on Midleg (SCM) Repressor Protein
Genetics, October 1, 1998; 150(2): 675 - 686.
[Abstract] [Full Text]

Home page
 GeneticsHome page
O. Saget, F. Forquignon, P. Santamaria, and N. B. Randsholt
Needs and Targets for the multi sex combs Gene Product in Drosophila melanogaster
Genetics, August 1, 1998; 149(4): 1823 - 1838.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
S. E. Roche and D. C. Rio
Trans-Silencing by P Elements Inserted in Subtelomeric Heterochromatin Involves the Drosophila Polycomb Group Gene, Enhancer of zeste
Genetics, August 1, 1998; 149(4): 1839 - 1855.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
M. van Lohuizen, M. Tijms, J. W. Voncken, A. Schumacher, T. Magnuson, and E. Wientjens
Interaction of Mouse Polycomb-Group (Pc-G) Proteins Enx1 and Enx2 with Eed: Indication for Separate Pc-G Complexes
Mol. Cell. Biol., June 1, 1998; 18(6): 3572 - 3579.
[Abstract] [Full Text]

Home page
 Mol. Cell. Biol.Home page
R. G. A. B. Sewalt, J. van der Vlag, M. J. Gunster, K. M. Hamer, J. L. den Blaauwen, D. P. E. Satijn, T. Hendrix, R. van Driel, and A. P. Otte
Characterization of Interactions between the Mammalian Polycomb-Group Proteins Enx1/EZH2 and EED Suggests the Existence of Different Mammalian Polycomb-Group Protein Complexes
Mol. Cell. Biol., June 1, 1998; 18(6): 3586 - 3595.
[Abstract] [Full Text]

Home page
 Mol. Cell. Biol.Home page
M. Kyba and H. W. Brock
The Drosophila Polycomb Group Protein Psc Contacts ph and Pc through Specific Conserved Domains
Mol. Cell. Biol., May 1, 1998; 18(5): 2712 - 2720.
[Abstract] [Full Text]

Home page
 Mol. Cell. Biol.Home page
C. A. Jones, J. Ng, A. J. Peterson, K. Morgan, J. Simon, and R. S. Jones
The Drosophila esc and E(z) Proteins Are Direct Partners in Polycomb Group-Mediated Repression
Mol. Cell. Biol., May 1, 1998; 18(5): 2825 - 2834.
[Abstract] [Full Text]

Home page
 JCBHome page
P. Buchenau, J. Hodgson, H. Strutt, and D. J. Arndt-Jovin
The Distribution of Polycomb-Group Proteins During Cell Division and Development in Drosophila Embryos: Impact on Models for Silencing
J. Cell Biol., April 20, 1998; 141(2): 469 - 481.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
U. Grossniklaus, J. Vielle-Calzada, M. A. Hoeppner, and W. B. Gagliano
Maternal Control of Embryogenesis by MEDEA, a Polycomb Group Gene in Arabidopsis
Science, April 17, 1998; 280(5362): 446 - 450.
[Abstract] [Full Text]

Home page
 GeneticsHome page
C. Rosen, D. Dorsett, and J. Jack
A Proline-Rich Region in the Zeste Protein Essential for Transvection and white Repression by Zeste1
Genetics, April 1, 1998; 148(4): 1865 - 1874.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
K Stankunas, J Berger, C Ruse, D. Sinclair, F Randazzo, and H. Brock
The enhancer of polycomb gene of Drosophila encodes a chromatin protein conserved in yeast and mammals
Development, January 10, 1998; 125(20): 4055 - 4066.
[Abstract] [PDF]

Home page
 DevelopmentHome page
F Tie, T Furuyama, and P. Harte
The Drosophila Polycomb Group proteins ESC and E(Z) bind directly to each other and co-localize at multiple chromosomal sites
Development, January 9, 1998; 125(17): 3483 - 3496.
[Abstract] [PDF]

Home page
 DevelopmentHome page
S Bel, N Core, M Djabali, K Kieboom, N Van der Lugt, M. Alkema, and M Van Lohuizen
Genetic interactions and dosage effects of Polycomb group genes in mice
Development, January 9, 1998; 125(18): 3543 - 3551.
[Abstract] [PDF]

Home page
 DevelopmentHome page
R Holdeman, S Nehrt, and S Strome
MES-2, a maternal protein essential for viability of the germline in Caenorhabditis elegans, is homologous to a Drosophila Polycomb group protein
Development, January 7, 1998; 125(13): 2457 - 2467.
[Abstract] [PDF]

Home page
 DevelopmentHome page
I Korf, Y Fan, and S Strome
The Polycomb group in Caenorhabditis elegans and maternal control of germline development
Development, January 7, 1998; 125(13): 2469 - 2478.
[Abstract] [PDF]

Home page
 DevelopmentHome page
D. Sinclair, T. Milne, J. Hodgson, J Shellard, C. Salinas, M Kyba, F Randazzo, and H. Brock
The Additional sex combs gene of Drosophila encodes a chromatin protein that binds to shared and unique Polycomb group sites on polytene chromosomes
Development, January 4, 1998; 125(7): 1207 - 1216.
[Abstract] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Shimono, H. Murakami, Y. Hasegawa, and M. Takahashi
RET Finger Protein Is a Transcriptional Repressor and Interacts with Enhancer of Polycomb That Has Dual Transcriptional Functions
J. Biol. Chem., December 8, 2000; 275(50): 39411 - 39419.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 1996