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Development, Vol 122, Issue 2 509-520, Copyright © 1996 by Company of Biologists
JOURNAL ARTICLES |
J Collignon, S Sockanathan, A Hacker, M Cohen-Tannoudji, D Norris, S Rastan, M Stevanovic, PN Goodfellow and R Lovell-Badge
Laboratory of Developmental Genetics, MRC National Institute for Medical Research, London, UK.
The Sox gene family consists of a large number of embryonically expressed genes related via the possession of a 79-amino-acid DNA-binding domain known as the HMG box. Partial clones for the first three Sox genes (al-a3) were isolated by homology to the HMG box of the testis-determining gene Sry and are now termed Sox-1, Sox-2 and Sox-3, Sox-3 is highly conserved amongst mammalian species and is located on the X chromosome. This has led to the proposal that Sry evolved from Sox-3. We present the cloning and sequencing of Sox-1, Sox-2 and Sox-3 from the mouse and show that Sox-3 is most closely relate to Sry. We also confirm that mouse Sox-3 is located on the X chromosome between Hprt and Dmd. Analysis of the distribution of Sox-3 RNA shows that its main site of expression is in the developing central nervous system, suggesting a role for Sox-3 in neural development. Moreover, we demonstrate that Sox-3, as well as Sox-1 and Sox-2, are expressed in the urogenital ridge and that their protein products are able to bind the same DNA sequence motif as Sry in vitro, but with different affinities. These observations prompt discussion of an evolutionary link between the genes and support the model that Sry has evolved from Sox-3. However our findings imply that if this is true, then Sry has undergone concomitant changes resulting in loss of CNS expression and altered DNA-binding properties.
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V. Botquin, H. Hess, G. Fuhrmann, C. Anastassiadis, M. K. Gross, G. Vriend, and H. R. Schöler New POU dimer configuration mediates antagonistic control of an osteopontin preimplantation enhancer by Oct-4 and Sox-2 Genes & Dev., July 1, 1998; 12(13): 2073 - 2090. [Abstract] [Full Text]
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S. Nishiguchi, H. Wood, H. Kondoh, R. Lovell-Badge, and V. Episkopou Sox1 directly regulates the gamma -crystallin genes and is essential for lens development in mice Genes & Dev., March 15, 1998; 12(6): 776 - 781. [Abstract] [Full Text]
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N. Soriano and S Russell The Drosophila SOX-domain protein Dichaete is required for the development of the central nervous system midline Development, January 10, 1998; 125(20): 3989 - 3996. [Abstract] [PDF]
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C. Zygar, T. Cook, and R. Grainger Gene activation during early stages of lens induction in Xenopus Development, January 9, 1998; 125(17): 3509 - 3519. [Abstract] [PDF]
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Y Kamachi, M Uchikawa, J Collignon, R Lovell-Badge, and H Kondoh Involvement of Sox1, 2 and 3 in the early and subsequent molecular events of lens induction Development, January 7, 1998; 125(13): 2521 - 2532. [Abstract] [PDF]
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L. Pevny, S Sockanathan, M Placzek, and R Lovell-Badge A role for SOX1 in neural determination Development, January 5, 1998; 125(10): 1967 - 1978. [Abstract] [PDF]
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M Rhinn, A Dierich, W Shawlot, R. Behringer, M Le Meur, and S. Ang Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification Development, January 3, 1998; 125(5): 845 - 856. [Abstract] [PDF]
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K Mizuseki, M Kishi, M Matsui, S Nakanishi, and Y Sasai Xenopus Zic-related-1 and Sox-2, two factors induced by chordin, have distinct activities in the initiation of neural induction Development, January 2, 1998; 125(4): 579 - 587. [Abstract] [PDF]
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B. Ciruna, L Schwartz, K Harpal, T. Yamaguchi, and J Rossant Chimeric analysis of fibroblast growth factor receptor-1 (Fgfr1) function: a role for FGFR1 in morphogenetic movement through the primitive streak Development, January 7, 1997; 124(14): 2829 - 2841. [Abstract] [PDF]
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E Cau, G Gradwohl, C Fode, and F Guillemot Mash1 activates a cascade of bHLH regulators in olfactory neuron progenitors Development, January 4, 1997; 124(8): 1611 - 1621. [Abstract] [PDF]
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S. Russell, N Sanchez-Soriano, C. Wright, and M Ashburner The Dichaete gene of Drosophila melanogaster encodes a SOX-domain protein required for embryonic segmentation Development, January 11, 1996; 122(11): 3669 - 3676. [Abstract] [PDF]
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