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Development, Vol 122, Issue 4 1147-1155, Copyright © 1996 by Company of Biologists
JOURNAL ARTICLES |
K Patel, R Nittenberg, D D'Souza, C Irving, D Burt, DG Wilkinson and C Tickle
Division of Developmental Neurobiology, National Institute for Medical Research, London, UK.
The Eph-related receptor tyrosine kinase gene, Cek-8, is expressed in mesenchyme at the tip of chick limb buds, with high levels of transcripts posteriorly and apically but fading out anteriorly. Expression of Cek-8 in distal mesenchyme is regulated by apical ridge- and FGF-polarising signals and retinoic acid, and is uniform across the anteroposterior axis in talpid3 mutants. These data indicate that Cek-8 expression responds to regulatory signals during limb patterning and suggest that this receptor tyrosine kinase may have a role in coordinating responses to signals in the progress zone of early buds. Later on in limb development, Cek-8 expression is associated with cell condensations that form tendons and their attachments to cartilage rudiments and then in developing feather buds.
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