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Development, Vol 122, Issue 7 2153-2162, Copyright © 1996 by Company of Biologists
JOURNAL ARTICLES |
V. Wiersdorff, T. Lecuit, S. M. Cohen and M. Mlodzik
Decapentaplegic (Dpp), a member of the TGF-betta family of cytokines, has been implicated in many patterning processes in Drosophila, including the initial steps of pattern formation in the developing eye. We show that the Mothers against dpp (Mad) gene is required for dpp signaling during eye development. Clonal analysis demonstrates a cell-autonomous function for Mad and genetic interactions indicate that Mad is an essential component of the signal transduction pathway downstream of the Dpp receptors in responding cells. Mad-mediated dpp signaling is absolutely required for the initiation of the morphogenetic furrow in the eye, but has only a minor role in its subsequent propagation across the eye
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D. Hazelett, M Bourouis, U Walldorf, and J. Treisman decapentaplegic and wingless are regulated by eyes absent and eyegone and interact to direct the pattern of retinal differentiation in the eye disc Development, January 9, 1998; 125(18): 3741 - 3751. [Abstract] [PDF]
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R. Wisotzkey, A Mehra, D. Sutherland, L. Dobens, X Liu, C Dohrmann, L Attisano, and L. Raftery Medea is a Drosophila Smad4 homolog that is differentially required to potentiate DPP responses Development, January 4, 1998; 125(8): 1433 - 1445. [Abstract] [PDF]
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P Das, L. Maduzia, H Wang, A. Finelli, S. Cho, M. Smith, and R. Padgett The Drosophila gene Medea demonstrates the requirement for different classes of Smads in dpp signaling Development, January 4, 1998; 125(8): 1519 - 1528. [Abstract] [PDF]
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U Heberlein, E. Borod, and F. Chanut Dorsoventral patterning in the Drosophila retina by wingless Development, January 2, 1998; 125(4): 567 - 577. [Abstract] [PDF]
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C. Sirard, J. L. de la Pompa, A. Elia, A. Itie, C. Mirtsos, A. Cheung, S. Hahn, A. Wakeham, L. Schwartz, S. E. Kern, et al. The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo Genes & Dev., January 1, 1998; 12(1): 107 - 119. [Abstract] [Full Text]
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F. Liu, C. Pouponnot, and J. Massague Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta -inducible transcriptional complexes Genes & Dev., December 1, 1997; 11(23): 3157 - 3167. [Abstract] [Full Text] [PDF]
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S. Abdollah, M. Macias-Silva, T. Tsukazaki, H. Hayashi, L. Attisano, and J. L. Wrana Tbeta RI Phosphorylation of Smad2 on Ser465 and Ser467 Is Required for Smad2-Smad4 Complex Formation and Signaling J. Biol. Chem., October 31, 1997; 272(44): 27678 - 27685. [Abstract] [Full Text] [PDF]
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S. Souchelnytskyi, K. Tamaki, U. Engstrom, C. Wernstedt, P. ten Dijke, and C.-H. Heldin Phosphorylation of Ser465 and Ser467 in the C Terminus of Smad2 Mediates Interaction with Smad4 and Is Required for Transforming Growth Factor-beta Signaling J. Biol. Chem., October 31, 1997; 272(44): 28107 - 28115. [Abstract] [Full Text] [PDF]
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 M. Li, J. Li, P. A. Hoodless, T. Tzukazaki, J. L. Wrana, L. Attisano, and B. K. Tsang Mothers Against Decapentaplegic-Related Protein 2 Expression in Avian Granulosa Cells Is Up-Regulated by Transforming Growth Factor {beta} during Ovarian Follicular Development Endocrinology, September 1, 1997; 138(9): 3659 - 3665. [Abstract] [Full Text] [PDF]
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 J. N. Topper, J. Cai, Y. Qiu, K. R. Anderson, Y.-Y. Xu, J. D. Deeds, R. Feeley, C. J. Gimeno, E. A. Woolf, O. Tayber, et al. Vascular MADs: Two novel MAD-related genes selectively inducible by flow in human vascular endothelium PNAS, August 19, 1997; 94(17): 9314 - 9319. [Abstract] [Full Text] [PDF]
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J. E. Treisman, A. Luk, G. M. Rubin, and U. Heberlein eyelid antagonizes wingless signaling during Drosophila development and has homology to the Bright family of DNA-binding proteins Genes & Dev., August 1, 1997; 11(15): 1949 - 1962. [Abstract] [Full Text] [PDF]
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M Kretzschmar, F Liu, A Hata, J Doody, and J Massague The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase. Genes & Dev., April 15, 1997; 11(8): 984 - 995. [Abstract] [PDF]
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A. Nakao, E. Roijer, T. Imamura, S. Souchelnytskyi, G. Stenman, C.-H. Heldin, and P. ten Dijke Identification of Smad2, a Human Mad-related Protein in the Transforming Growth Factor beta Signaling Pathway J. Biol. Chem., January 31, 1997; 272(5): 2896 - 2900. [Abstract] [Full Text] [PDF]
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J Royet and R Finkelstein Establishing primordia in the Drosophila eye-antennal imaginal disc: the roles of decapentaplegic, wingless and hedgehog Development, January 12, 1997; 124(23): 4793 - 4800. [Abstract] [PDF]
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D. Strutt and M Mlodzik Hedgehog is an indirect regulator of morphogenetic furrow progression in the Drosophila eye disc Development, January 9, 1997; 124(17): 3233 - 3240. [Abstract] [PDF]
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S. Newfeld, A Mehra, M. Singer, J. Wrana, L Attisano, and W. Gelbart Mothers against dpp participates in a DDP/TGF-beta responsive serine-threonine kinase signal transduction cascade Development, January 8, 1997; 124(16): 3167 - 3176. [Abstract] [PDF]
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W Shen and G Mardon Ectopic eye development in Drosophila induced by directed dachshund expression Development, January 1, 1997; 124(1): 45 - 52. [Abstract] [PDF]
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M. Singer, A Penton, V Twombly, F. Hoffmann, and W. Gelbart Signaling through both type I DPP receptors is required for anterior-posterior patterning of the entire Drosophila wing Development, January 1, 1997; 124(1): 79 - 89. [Abstract] [PDF]
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F Chanut and U Heberlein Role of decapentaplegic in initiation and progression of the morphogenetic furrow in the developing Drosophila retina Development, January 1, 1997; 124(2): 559 - 567. [Abstract] [PDF]
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H Theisen, T. Haerry, M. O'Connor, and J. Marsh Developmental territories created by mutual antagonism between Wingless and Decapentaplegic Development, January 12, 1996; 122(12): 3939 - 3948. [Abstract] [PDF]
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