|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 122, Issue 8 2517-2527, Copyright © 1996 by Company of Biologists
JOURNAL ARTICLES |
JC Bettinger, K Lee and AE Rougvie
Department of Genetics and Cell Biology, University of Minnesota, St Paul 55108, USA.
The Caenorhabditis elegans gene lin-29 is required for the terminal differentiation of the lateral hypodermal seam cells during the larval-to-adult molt. We find that lin-29 protein accumulates in the nuclei of these cells, consistent with its predicted role as a zinc finger transcription factor. The earliest detectable LIN-29 accumulation in seam cell nuclei is during the last larval stage (L4), following the final seam cell division, which occurs during the L3-to-L4 molt. LIN-29 accumulates in all hypodermal nuclei during the L4 stage. The time of LIN-29 appearance in the hypodermis is controlled by the heterochronic gene pathway: LIN-29 accumulates in the hypodermis abnormally early, during the third larval stage, in loss-of-function lin-14, lin-28 and lin-42 mutants, and fails to accumulate in hypodermis of lin-4 mutants. LIN-29 also accumulates stage-specifically in the nuclei of a variety of non-hypodermal cells during development. Its accumulation is dependent upon the upstream heterochronic genes in some, but not all, of these non-hypodermal cells.
This article has been cited by other articles:
|
|
 |
|
  Q. Cai, Y. Sun, X. Huang, C. Guo, Y. Zhang, Z. Zhu, and H. Zhang The Caenorhabditis elegans PcG-like Gene sop-2 Regulates the Temporal and Sexual Specificities of Cell Fates Genetics, March 1, 2008; 178(3): 1445 - 1456. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. de Souza, L. G. Vallier, H. Fares, and I. Greenwald SEL-2, the C. elegans neurobeachin/LRBA homolog, is a negative regulator of lin-12/Notch activity and affects endosomal traffic in polarized epithelial cells Development, February 15, 2007; 134(4): 691 - 702. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. D. Hayes, A. R. Frand, and G. Ruvkun The mir-84 and let-7 paralogous microRNA genes of Caenorhabditis elegans direct the cessation of molting via the conserved nuclear hormone receptors NHR-23 and NHR-25 Development, December 1, 2006; 133(23): 4631 - 4641. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Rowland, J. E. Richmond, J. G. Olsen, D. H. Hall, and B. A. Bamber Presynaptic Terminals Independently Regulate Synaptic Clustering and Autophagy of GABAA Receptors in Caenorhabditis elegans J. Neurosci., February 8, 2006; 26(6): 1711 - 1720. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Eastburn and M. Han A Gain-of-Function Allele of cbp-1, the Caenorhabditis elegans Ortholog of the Mammalian CBP/p300 Gene, Causes an Increase in Histone Acetyltransferase Activity and Antagonism of Activated Ras Mol. Cell. Biol., November 1, 2005; 25(21): 9427 - 9434. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Belfiore, P. Pugnale, Z. Saudan, and A. Puoti Roles of the C. elegans cyclophilin-like protein MOG-6 in MEP-1 binding and germline fates Development, June 15, 2004; 131(12): 2935 - 2945. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. D. Ackley, S. H. Kang, J. R. Crew, C. Suh, Y. Jin, and J. M. Kramer The Basement Membrane Components Nidogen and Type XVIII Collagen Regulate Organization of Neuromuscular Junctions in Caenorhabditis elegans J. Neurosci., May 1, 2003; 23(9): 3577 - 3587. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Jarriault and I. Greenwald Suppressors of the egg-laying defective phenotype of sel-12 presenilin mutants implicate the CoREST corepressor complex in LIN-12/Notch signaling in C. elegans Genes & Dev., October 15, 2002; 16(20): 2713 - 2728. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Chen and M. Han Role of C. elegans lin-40 MTA in vulval fate specification and morphogenesis Development, December 1, 2001; 128(23): 4911 - 4921. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Koh and J. H. Rothman ELT-5 and ELT-6 are required continuously to regulate epidermal seam cell differentiation and cell fusion in C. elegans Development, August 1, 2001; 128(15): 2867 - 2880. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Zhang, B. Grant, and D. Hirsh RME-8, a Conserved J-Domain Protein, Is Required for Endocytosis in Caenorhabditis elegans Mol. Biol. Cell, July 1, 2001; 12(7): 2011 - 2021. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Eisenmann and S. K. Kim Protruding Vulva Mutants Identify Novel Loci and Wnt Signaling Factors That Function During Caenorhabditis elegans Vulva Development Genetics, November 1, 2000; 156(3): 1097 - 1116. [Abstract] [Full Text]
|
|
|
|
|
|
A. Meléndez and I. Greenwald Caenorhabditis elegans lin-13, a Member of the LIN-35 Rb Class of Genes Involved in Vulval Development, Encodes a Protein With Zinc Fingers and an LXCXE Motif Genetics, July 1, 2000; 155(3): 1127 - 1137. [Abstract] [Full Text]
|
|
|
|
|
|
B. Grant and D. Hirsh Receptor-mediated Endocytosis in the Caenorhabditis elegans Oocyte Mol. Biol. Cell, December 1, 1999; 10(12): 4311 - 4326. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. Jeon, H. F. Gardner, E. A. Miller, J. Deshler, and A. E. Rougvie Similarity of the C. elegans Developmental Timing Protein LIN-42 to Circadian Rhythm Proteins Science, November 5, 1999; 286(5442): 1141 - 1146. [Abstract] [Full Text]
|
|
|
|
|
|
M Park and M. Krause Regulation of postembryonic G(1) cell cycle progression in Caenorhabditis elegans by a cyclin D/CDK-like complex Development, January 11, 1999; 126(21): 4849 - 4860. [Abstract] [PDF]
|
|
|
|
|
|
V Ambros Cell cycle-dependent sequencing of cell fate decisions in Caenorhabditis elegans vulva precursor cells Development, January 5, 1999; 126(9): 1947 - 1956. [Abstract] [PDF]
|
|
|
|
|
|
J Yochem, S Tuck, I Greenwald, and M Han A gp330/megalin-related protein is required in the major epidermis of Caenorhabditis elegans for completion of molting Development, January 2, 1999; 126(3): 597 - 606. [Abstract] [PDF]
|
|
|
|
|
|
J. Yochem, T. Gu, and M. Han A New Marker for Mosaic Analysis in Caenorhabditis elegans Indicates a Fusion Between hyp6 and hyp7, Two Major Components of the Hypodermis Genetics, July 1, 1998; 149(3): 1323 - 1334. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Abrahante, E. A. Miller, and A. E. Rougvie Identification of Heterochronic Mutants in Caenorhabditis elegans: Temporal Misexpression of a Collagen::Green Fluorescent Protein Fusion Gene Genetics, July 1, 1998; 149(3): 1335 - 1351. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L Nilsson, X Li, T Tiensuu, R Auty, I Greenwald, and S Tuck Caenorhabditis elegans lin-25: cellular focus, protein expression and requirement for sur-2 during induction of vulval fates Development, January 12, 1998; 125(23): 4809 - 4819. [Abstract] [PDF]
|
|
|
|
|
|
D Levitan and I Greenwald Effects of SEL-12 presenilin on LIN-12 localization and function in Caenorhabditis elegans Development, January 9, 1998; 125(18): 3599 - 3606. [Abstract] [PDF]
|
|
|
|
|
|
D Levitan and I Greenwald LIN-12 protein expression and localization during vulval development in C. elegans Development, January 8, 1998; 125(16): 3101 - 3109. [Abstract] [PDF]
|
|
|
|
|
|
A Antebi, J. Culotti, and E. Hedgecock daf-12 regulates developmental age and the dauer alternative in Caenorhabditis elegans Development, January 4, 1998; 125(7): 1191 - 1205. [Abstract] [PDF]
|
|
|
|
|
|
J. Bettinger, S Euling, and A. Rougvie The terminal differentiation factor LIN-29 is required for proper vulval morphogenesis and egg laying in Caenorhabditis elegans Development, January 11, 1997; 124(21): 4333 - 4342. [Abstract] [PDF]
|
|
