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Development, Vol 123, Issue 1 67-80, Copyright © 1996 by Company of Biologists
JOURNAL ARTICLES |
L Solnica-Krezel, DL Stemple, E Mountcastle-Shah, Z Rangini, SC Neuhauss, J Malicki, AF Schier, DY Stainier, F Zwartkruis, S Abdelilah and W Driever
Cardiovascular Research Center, Massachusetts General Hospital, Charlestown 02129, USA.
One of the major challenges of developmental biology is understanding the inductive and morphogenetic processes that shape the vertebrate embryo. In a large-scale genetic screen for zygotic effect, embryonic lethal mutations in zebrafish we have identified 25 mutations that affect specification of cell fates and/or cellular rearrangements during gastrulation. These mutations define at least 14 complementation groups, four of which correspond to previously identified genes. Phenotypic analysis of the ten novel loci revealed three groups of mutations causing distinct effects on cell fates in the gastrula. One group comprises mutations that lead to deficiencies in dorsal mesodermal fates and affect central nervous system patterning. Mutations from the second group affect formation of ventroposterior embryonic structures. We suggest that mutations in these two groups identify genes necessary for the formation, maintenance or function of the dorsal organizer and the ventral signaling pathway, respectively. Mutations in the third group affect primarily cellular rearrangements during gastrulation and have complex effects on cell fates in the embryo. This group, and to some extent mutations from the first two groups, affect the major morphogenetic processes, epiboly, convergence and extension, and tail morphogenesis. These mutations provide an approach to understanding the genetic control of gastrulation in vertebrates.
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W Driever, L Solnica-Krezel, A. Schier, S. Neuhauss, J Malicki, D. Stemple, D. Stainier, F Zwartkruis, S Abdelilah, Z Rangini, et al. A genetic screen for mutations affecting embryogenesis in zebrafish Development, January 12, 1996; 123(1): 37 - 46. [Abstract] [PDF]
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D. Stemple, L Solnica-Krezel, F Zwartkruis, S. Neuhauss, A. Schier, J Malicki, D. Stainier, S Abdelilah, Z Rangini, E Mountcastle-Shah, et al. Mutations affecting development of the notochord in zebrafish Development, January 12, 1996; 123(1): 117 - 128. [Abstract] [PDF]
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M Hammerschmidt, F Pelegri, M. Mullins, D. Kane, M Brand, F. van Eeden, M Furutani-Seiki, M Granato, P Haffter, C. Heisenberg, et al. Mutations affecting morphogenesis during gastrulation and tail formation in the zebrafish, Danio rerio Development, January 12, 1996; 123(1): 143 - 151. [Abstract] [PDF]
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A. Schier, S. Neuhauss, M Harvey, J Malicki, L Solnica-Krezel, D. Stainier, F Zwartkruis, S Abdelilah, D. Stemple, Z Rangini, et al. Mutations affecting the development of the embryonic zebrafish brain Development, January 12, 1996; 123(1): 165 - 178. [Abstract] [PDF]
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J Malicki, S. Neuhauss, A. Schier, L Solnica-Krezel, D. Stemple, D. Stainier, S Abdelilah, F Zwartkruis, Z Rangini, and W Driever Mutations affecting development of the zebrafish retina Development, January 12, 1996; 123(1): 263 - 273. [Abstract] [PDF]
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S. Neuhauss, L Solnica-Krezel, A. Schier, F Zwartkruis, D. Stemple, J Malicki, S Abdelilah, D. Stainier, and W Driever Mutations affecting craniofacial development in zebrafish Development, January 12, 1996; 123(1): 357 - 367. [Abstract] [PDF]
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