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Development, Vol 123, Issue 1 95-102, Copyright © 1996 by Company of Biologists
JOURNAL ARTICLES |
M Hammerschmidt, F Pelegri, MC Mullins, DA Kane, FJ van Eeden, M Granato, M Brand, M Furutani-Seiki, P Haffter, CP Heisenberg, YJ Jiang, RN Kelsh, J Odenthal, RM Warga and C Nusslein-Volhard
Max-Planck-Institut fur Entwicklungsbiologie, Abteilung fur Genetik, Tubingen, Germany. Mhammer@hubio2.harvard.edu
We describe two genes, dino and mercedes, which are required for the organization of the zebrafish body plan. In dino mutant embryos, the tail is enlarged at the expense of the head and the anterior region of the trunk. The altered expression patterns of various marker genes reveal that, with the exception of the dorsal most marginal zone, all regions of the early dino mutant embryo acquire more ventral fates. These alterations are already apparent before the onset of gastrulation. mercedes mutant embryos show a similar but weaker phenotype, suggesting a role in the same patterning processes. The phenotypes suggests that dino and mercedes are required for the establishment of dorsal fates in both the marginal and the animal zone of the early gastrula embryo. Their function in the patterning of the ventrolateral mesoderm and the induction of the neuroectoderm is similar to the function of the Spemann organizer in the amphibian embryo.
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M Hild, A Dick, G. Rauch, A Meier, T Bouwmeester, P Haffter, and M Hammerschmidt The smad5 mutation somitabun blocks Bmp2b signaling during early dorsoventral patterning of the zebrafish embryo Development, January 5, 1999; 126(10): 2149 - 2159. [Abstract] [PDF]
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Y Grinblat, J Gamse, M Patel, and H Sive Determination of the zebrafish forebrain: induction and patterning Development, January 11, 1998; 125(22): 4403 - 4416. [Abstract] [PDF]
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S. Amacher and C. Kimmel Promoting notochord fate and repressing muscle development in zebrafish axial mesoderm Development, January 4, 1998; 125(8): 1397 - 1406. [Abstract] [PDF]
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P. Blader, S. Rastegar, N. Fischer, and U. Strähle Cleavage of the BMP-4 Antagonist Chordin by Zebrafish Tolloid Science, December 12, 1997; 278(5345): 1937 - 1940. [Abstract] [Full Text]
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M Furthauer, C Thisse, and B Thisse A role for FGF-8 in the dorsoventral patterning of the zebrafish gastrula Development, January 11, 1997; 124(21): 4253 - 4264. [Abstract] [PDF]
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J. Chen, F. van Eeden, K. Warren, A Chin, C Nusslein-Volhard, P Haffter, and M. Fishman Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish Development, January 11, 1997; 124(21): 4373 - 4382. [Abstract] [PDF]
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Y Kishimoto, K. Lee, L Zon, M Hammerschmidt, and S Schulte-Merker The molecular nature of zebrafish swirl: BMP2 function is essential during early dorsoventral patterning Development, January 11, 1997; 124(22): 4457 - 4466. [Abstract] [PDF]
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S Fisher, S. Amacher, and M. Halpern Loss of cerebum function ventralizes the zebrafish embryo Development, January 4, 1997; 124(7): 1301 - 1311. [Abstract] [PDF]
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 E.M. De Robertis, S. Kim, L. Leyns, S. Piccolo, D. Bachiller, E. Agius, J.A. Belo, A. Yamamoto, A. Hainski-Brousseau, B. Brizuela, et al. Patterning by Genes Expressed in Spemann's Organizer Cold Spring Harb Symp Quant Biol, January 1, 1997; 62(0): 169 - 175. [Abstract] [PDF]
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G.-J. Rauch, M. Hammerschmidt, P. Blader, H.E. Schauerte, U. Strahle, P.W. Ingham, A.P. McMahon, and P. Haffter WNT5 Is Required for Tail Formation in the Zebrafish Embryo Cold Spring Harb Symp Quant Biol, January 1, 1997; 62(0): 227 - 234. [Abstract] [PDF]
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W. Driever, L. Solnica-Krezel, S. Abdelilah, D. Meyer, and D. Stemple Genetic Analysis of Pattern Formation in the Zebrafish Neural Plate Cold Spring Harb Symp Quant Biol, January 1, 1997; 62(0): 523 - 534. [Abstract] [PDF]
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A. Schier, S. Neuhauss, K. Helde, W. Talbot, and W Driever The one-eyed pinhead gene functions in mesoderm and endoderm formation in zebrafish and interacts with no tail Development, January 1, 1997; 124(2): 327 - 342. [Abstract] [PDF]
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M Hammerschmidt, G N Serbedzija, and A P McMahon Genetic analysis of dorsoventral pattern formation in the zebrafish: requirement of a BMP-like ventralizing activity and its dorsal repressor. Genes & Dev., October 1, 1996; 10(19): 2452 - 2461. [Abstract] [PDF]
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P Haffter, M Granato, M Brand, M. Mullins, M Hammerschmidt, D. Kane, J Odenthal, F. van Eeden, Y. Jiang, C. Heisenberg, et al. The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio Development, January 12, 1996; 123(1): 1 - 36. [Abstract] [PDF]
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D. Kane, H. Maischein, M Brand, F. van Eeden, M Furutani-Seiki, M Granato, P Haffter, M Hammerschmidt, C. Heisenberg, Y. Jiang, et al. The zebrafish early arrest mutants Development, January 12, 1996; 123(1): 57 - 66. [Abstract] [PDF]
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M. Mullins, M Hammerschmidt, D. Kane, J Odenthal, M Brand, F. van Eeden, M Furutani-Seiki, M Granato, P Haffter, C. Heisenberg, et al. Genes establishing dorsoventral pattern formation in the zebrafish embryo: the ventral specifying genes Development, January 12, 1996; 123(1): 81 - 93. [Abstract] [PDF]
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M Hammerschmidt, F Pelegri, M. Mullins, D. Kane, M Brand, F. van Eeden, M Furutani-Seiki, M Granato, P Haffter, C. Heisenberg, et al. Mutations affecting morphogenesis during gastrulation and tail formation in the zebrafish, Danio rerio Development, January 12, 1996; 123(1): 143 - 151. [Abstract] [PDF]
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F. van Eeden, M Granato, U Schach, M Brand, M Furutani-Seiki, P Haffter, M Hammerschmidt, C. Heisenberg, Y. Jiang, D. Kane, et al. Mutations affecting somite formation and patterning in the zebrafish, Danio rerio Development, January 12, 1996; 123(1): 153 - 164. [Abstract] [PDF]
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M Furutani-Seiki, Y. Jiang, M Brand, C. Heisenberg, C Houart, D Beuchle, F. van Eeden, M Granato, P Haffter, M Hammerschmidt, et al. Neural degeneration mutants in the zebrafish, Danio rerio Development, January 12, 1996; 123(1): 229 - 239. [Abstract] [PDF]
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