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Development, Vol 124, Issue 11 2179-2189, Copyright © 1997 by Company of Biologists
JOURNAL ARTICLES |
M Krause, M Park, JM Zhang, J Yuan, B Harfe, SQ Xu, I Greenwald, M Cole, B Paterson and A Fire
Laboratory of Molecular Biology, NIDDK, NIH, Bethesda, MD 20892-0510, USA. mwkrause@helix.nih.gov
The E proteins of mammals, and the related Daughterless (DA) protein of Drosophila, are ubiquitously expressed helix-loop-helix (HLH) transcription factors that play a role in many developmental processes. We report here the characterization of a related C. elegans protein, CeE/DA, which has a dynamic and restricted distribution during development. CeE/DA is present embryonically in neuronal precursors, some of which are marked by promoter activity of a newly described Achaete-scute-like gene hlh-3. In contrast, we have been unable to detect CeE/DA in CeMyoD-positive striated muscle cells. In vitro gel mobility shift analysis detects dimerization of CeE/DA with HLH-3 while efficient interaction of CeE/DA with CeMyoD is not seen. These studies suggest multiple roles for CeE/DA in C. elegans development and provide evidence that both common and alternative strategies have evolved for the use of related HLH proteins in controlling cell fates in different species.
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