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Development, Vol 124, Issue 15 2973-2981, Copyright © 1997 by Company of Biologists
JOURNAL ARTICLES |
RJ Fleming, Y Gu and NA Hukriede
Department of Biology, The University of Rochester, NY 14627, USA. flem@uhura.cc.rochester.edu
In the developing imaginal wing disc of Drosophila, cells at the dorsoventral boundary require localized Notch activity for specification of the wing margin. The Notch ligands Serrate and Delta are required on opposite sides of the presumptive wing margin and, even though activated forms of Notch generate responses on both sides of the dorsoventral boundary, each ligand generates a compartment-specific response. In this report we demonstrate that Serrate, which is expressed in the dorsal compartment, does not signal in the dorsal regions due to the action of the fringe gene product. Using ectopic expression, we show that regulation of Serrate by fringe occurs at the level of protein and not Serrate transcription. Furthermore, replacement of the N-terminal region of Serrate with the corresponding region of Delta abolishes the ability of fringe to regulate Serrate without altering Serrate-specific signaling.
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X Sun and S Artavanis-Tsakonas Secreted forms of DELTA and SERRATE define antagonists of Notch signaling in Drosophila Development, January 9, 1997; 124(17): 3439 - 3448. [Abstract] [PDF]
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J. Chen, D. J. Moloney, and P. Stanley Fringe modulation of Jagged1-induced Notch signaling requires the action of beta 4galactosyltransferase-1 PNAS, November 20, 2001; 98(24): 13716 - 13721. [Abstract] [Full Text] [PDF]
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