|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 124, Issue 18 3597-3607, Copyright © 1997 by Company of Biologists
JOURNAL ARTICLES |
JT Wong, WT Yu and TP O'Connor
Department of Anatomy, University of British Columbia, Vancouver, Canada.
Members of the Semaphorin family of glycoproteins play an important role in axonal pathfinding by functioning as inhibitory guidance cues. Here we provide evidence that a transmembrane form of Semaphorin (Semaphorin I), which is expressed by bands of epithelial cells in the developing grasshopper limb bud, functions as an attractive/permissive cue for the growth cones of the subgenual organ. In addition, we demonstrate that Semaphorin I is needed for initial axonal outgrowth from the subgenual organ. These results are consistent with an alternative function for a transmembrane form of Semaphorin and may explain the previously reported arrest of the proximal extension of the subgenual organ growth cones in the absence of the Ti1 pioneer pathway.
This article has been cited by other articles:
|
|
 |
|
  M. Autiero, F. De Smet, F. Claes, and P. Carmeliet Role of neural guidance signals in blood vessel navigation Cardiovasc Res, February 15, 2005; 65(3): 629 - 638. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Xiao, W. Shoji, W. Zhou, F. Su, and J. Y. Kuwada Transmembrane Sema4E Guides Branchiomotor Axons to Their Targets in Zebrafish J. Neurosci., May 15, 2003; 23(10): 4190 - 4198. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. T. Legg and T. P. O'Connor Gradients and Growth Cone Guidance of Grasshopper Neurons J. Histochem. Cytochem., April 1, 2003; 51(4): 445 - 454. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Fujii, F. Nakao, Y. Shibata, G. Shioi, E. Kodama, H. Fujisawa, and S. Takagi Caenorhabditis elegans PlexinA, PLX-1, interacts with transmembrane semaphorins and regulates epidermal morphogenesis Development, January 5, 2002; 129(9): 2053 - 2063. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X.-M. Xu, D. A. Fisher, L. Zhou, F. A. White, S. Ng, W. D. Snider, and Y. Luo The Transmembrane Protein Semaphorin 6A Repels Embryonic Sympathetic Axons J. Neurosci., April 1, 2000; 20(7): 2638 - 2648. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Brambilla, B. Constantin, H. Drabkin, and J. Roche Semaphorin SEMA3F Localization in Malignant Human Lung and Cell Lines : A Suggested Role in Cell Adhesion and Cell Migration Am. J. Pathol., March 1, 2000; 156(3): 939 - 950. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Roy, H Zheng, C. Warren, and J. Culotti mab-20 encodes Semaphorin-2a and is required to prevent ectopic cell contacts during epidermal morphogenesis in Caenorhabditis elegans Development, January 2, 2000; 127(4): 755 - 767. [Abstract] [PDF]
|
|
|
|
|
|
F. d. Castro, L. Hu, H. Drabkin, C. Sotelo, and A. Chedotal Chemoattraction and Chemorepulsion of Olfactory Bulb Axons by Different Secreted Semaphorins J. Neurosci., June 1, 1999; 19(11): 4428 - 4436. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Rabacchi, J. M. Solowska, B. Kruk, Y. Luo, J. A. Raper, and D. H. Baird Collapsin-1/Semaphorin-III/D Is Regulated Developmentally in Purkinje Cells and Collapses Pontocerebellar Mossy Fiber Neuronal Growth Cones J. Neurosci., June 1, 1999; 19(11): 4437 - 4448. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Isbister and T. P. O'Connor Filopodial Adhesion Does Not Predict Growth Cone Steering Events In Vivo J. Neurosci., April 1, 1999; 19(7): 2589 - 2600. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Encinas, K. Kikuchi, A. Chedotal, F. de Castro, C. S. Goodman, and T. Kimura Cloning, expression, and genetic mapping of Sema W, a member of the semaphorin family PNAS, March 2, 1999; 96(5): 2491 - 2496. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Isbister, A Tsai, S. Wong, A. Kolodkin, and T. O'Connor Discrete roles for secreted and transmembrane semaphorins in neuronal growth cone guidance in vivo Development, January 5, 1999; 126(9): 2007 - 2019. [Abstract] [PDF]
|
|
|
|
 |
|
 X. Xu, S. Ng, Z.-L. Wu, D. Nguyen, S. Homburger, C. Seidel-Dugan, A. Ebens, and Y. Luo Human Semaphorin K1 Is Glycosylphosphatidylinositol-linked and Defines a New Subfamily of Viral-related Semaphorins J. Biol. Chem., August 28, 1998; 273(35): 22428 - 22434. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D Bagnard, M Lohrum, D Uziel, A. Puschel, and J Bolz Semaphorins act as attractive and repulsive guidance signals during the development of cortical projections Development, January 12, 1998; 125(24): 5043 - 5053. [Abstract] [PDF]
|
|
|
|
|
|
A Chedotal, J. Del Rio, M Ruiz, Z He, V Borrell, F de Castro, F Ezan, C. Goodman, M Tessier-Lavigne, C Sotelo, et al. Semaphorins III and IV repel hippocampal axons via two distinct receptors Development, January 11, 1998; 125(21): 4313 - 4323. [Abstract] [PDF]
|
|
