|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 124, Issue 19 3693-3702, Copyright © 1997 by Company of Biologists
JOURNAL ARTICLES |
A Gavalas, M Davenne, A Lumsden, P Chambon and FM Rijli
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS/INSERM/ULP, College de France, CU de Strasbourg.
Segmentation plays an important role in neuronal diversification and organisation in the developing hindbrain. For instance, cranial nerve branchiomotor nuclei are organised segmentally within the basal plates of successive pairs of rhombomeres. To reach their targets, motor axons follow highly stereotyped pathways exiting the hindbrain only via specific exit points in the even-numbered rhombomeres. Hox genes are good candidates for controlling this pathfinding, since they are segmentally expressed and involved in rhombomeric patterning. Here we report that in Hoxa-2(-/-) embryos, the segmental identities of rhombomere (r) 2 and r3 are molecularly as well as anatomically altered. Cellular analysis by retrograde dye labelling reveals that r2 and r3 trigeminal motor axons turn caudally and exit the hindbrain from the r4 facial nerve exit point and not from their normal exit point in r2. Furthermore, dorsal r2-r3 patterning is affected, with loss of cochlear nuclei and enlargement of the lateral part of the cerebellum. These results point to a novel role for Hoxa-2 in the control of r2-r3 motor axon guidance, and also suggest that its absence may lead to homeotic changes in the alar plates of these rhombomeres.
This article has been cited by other articles:
|
|
 |
|
  M. Gouti and A. Gavalas Hoxb1 Controls Cell Fate Specification and Proliferative Capacity of Neural Stem and Progenitor Cells Stem Cells, August 1, 2008; 26(8): 1985 - 1997. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Lampe, O. A. Samad, A. Guiguen, C. Matis, S. Remacle, J. J. Picard, F. M. Rijli, and R. Rezsohazy An ultraconserved Hox-Pbx responsive element resides in the coding sequence of Hoxa2 and is active in rhombomere 4 Nucleic Acids Res., June 1, 2008; 36(10): 3214 - 3225. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Oury, Y. Murakami, J.-S. Renaud, M. Pasqualetti, P. Charnay, S.-Y. Ren, and F. M. Rijli Hoxa2- and Rhombomere-Dependent Development of the Mouse Facial Somatosensory Map Science, September 8, 2006; 313(5792): 1408 - 1413. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. W. Koster and S. E. Fraser FGF signaling mediates regeneration of the differentiating cerebellum through repatterning of the anterior hindbrain and reinitiation of neuronal migration. J. Neurosci., July 5, 2006; 26(27): 7293 - 7304. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Foucher, M. Mione, A. Simeone, D. Acampora, L. Bally-Cuif, and C. Houart Differentiation of cerebellar cell identities in absence of Fgf signalling in zebrafish Otx morphants Development, May 15, 2006; 133(10): 1891 - 1900. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Tumpel, F. Cambronero, L. M. Wiedemann, and R. Krumlauf Evolution of cis elements in the differential expression of two Hoxa2 coparalogous genes in pufferfish (Takifugu rubripes) PNAS, April 4, 2006; 103(14): 5419 - 5424. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Lamar and C. Kintner The Notch targets Esr1 and Esr10 are differentially regulated in Xenopus neural precursors Development, August 15, 2005; 132(16): 3619 - 3630. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. P. Coutinho, C. Borday, J. Gilthorpe, S. Jungbluth, J. Champagnat, A. Lumsden, and G. Fortin Induction of a Parafacial Rhythm Generator by Rhombomere 3 in the Chick Embryo J. Neurosci., October 20, 2004; 24(42): 9383 - 9390. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. W. Rhee, A. Arata, L. Selleri, Y. Jacobs, S. Arata, H. Onimaru, and M. L. Cleary Pbx3 Deficiency Results in Central Hypoventilation Am. J. Pathol., October 1, 2004; 165(4): 1343 - 1350. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. A. Samad, M. J. Geisen, G. Caronia, I. Varlet, V. Zappavigna, J. Ericson, C. Goridis, and F. M. Rijli Integration of anteroposterior and dorsoventral regulation of Phox2b transcription in cranial motoneuron progenitors by homeodomain proteins Development, August 15, 2004; 131(16): 4071 - 4083. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Briscoe and D. G. Wilkinson Establishing neuronal circuitry: Hox genes make the connection Genes & Dev., July 15, 2004; 18(14): 1643 - 1648. [Full Text] [PDF]
|
|
|
|
|
|
C. T. Miller, L. Maves, and C. B. Kimmel moz regulates Hox expression and pharyngeal segmental identity in zebrafish Development, May 15, 2004; 131(10): 2443 - 2461. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Hahm, E. Y. M. Sum, Y. Fujiwara, G. J. Lindeman, J. E. Visvader, and S. H. Orkin Defective Neural Tube Closure and Anteroposterior Patterning in Mice Lacking the LIM Protein LMO4 or Its Interacting Partner Deaf-1 Mol. Cell. Biol., March 1, 2004; 24(5): 2074 - 2082. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Murakami, M. Pasqualetti, Y. Takio, S. Hirano, F. M. Rijli, and S. Kuratani Segmental development of reticulospinal and branchiomotor neurons in lamprey: insights into the evolution of the vertebrate hindbrain Development, March 1, 2004; 131(5): 983 - 995. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Gavalas, C. Ruhrberg, J. Livet, C. E. Henderson, and R. Krumlauf Neuronal defects in the hindbrain of Hoxa1, Hoxb1 and Hoxb2 mutants reflect regulatory interactions among these Hox genes Development, December 1, 2003; 130(23): 5663 - 5679. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Guidato, F. Prin, and S. Guthrie Somatic motoneurone specification in the hindbrain: the influence of somite-derived signals, retinoic acid and Hoxa3 Development, July 1, 2003; 130(13): 2981 - 2996. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Theil, L. Ariza-McNaughton, M. Manzanares, J. Brodie, R. Krumlauf, and D. G. Wilkinson Requirement for downregulation of kreisler during late patterning of the hindbrain Development, March 5, 2003; 129(6): 1477 - 1485. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Ghislain, C. Desmarquet-Trin-Dinh, P. Gilardi-Hebenstreit, P. Charnay, and M. Frain Neural crest patterning: autoregulatory and crest-specific elements co-operate for Krox20 transcriptional control Development, March 1, 2003; 130(5): 941 - 953. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Hauptmann, H.-G. Belting, U. Wolke, K. Lunde, I. Soll, S. Abdelilah-Seyfried, V. Prince, and W. Driever spiel ohne grenzen/pou2 is required for zebrafish hindbrain segmentation Development, January 4, 2002; 129(7): 1645 - 1655. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Voiculescu, E. Taillebourg, C. Pujades, C. Kress, S. Buart, P. Charnay, and S. Schneider-Maunoury Hindbrain patterning: Krox20 couples segmentation and specification of regional identity Development, December 15, 2001; 128(24): 4967 - 4978. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Zhao and S. S. Potter Functional specificity of the Hoxa13 homeobox Development, August 15, 2001; 128(16): 3197 - 3207. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Gavalas, P. Trainor, L. Ariza-McNaughton, and R. Krumlauf Synergy between Hoxa1 and Hoxb1: the relationship between arch patterning and the generation of cranial neural crest Development, August 1, 2001; 128(15): 3017 - 3027. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Pasqualetti, M Ori, I Nardi, and F. Rijli Ectopic Hoxa2 induction after neural crest migration results in homeosis of jaw elements in Xenopus Development, January 12, 2000; 127(24): 5367 - 5378. [Abstract] [PDF]
|
|
|
|
|
|
J. Barrow, H. Stadler, and M. Capecchi Roles of Hoxa1 and Hoxa2 in patterning the early hindbrain of the mouse Development, January 3, 2000; 127(5): 933 - 944. [Abstract] [PDF]
|
|
|
|
|
|
C Irving and I Mason Signalling by FGF8 from the isthmus patterns anterior hindbrain and establishes the anterior limit of Hox gene expression Development, January 1, 2000; 127(1): 177 - 186. [Abstract] [PDF]
|
|
|
|
 |
|
 K. J. Millen, J. H. Millonig, R. J. T. Wingate, J. Alder, and M. E. Hatten Neurogenetics of the Cerebellar System J Child Neurol, September 1, 1999; 14(9): 574 - 581. [Abstract] [PDF]
|
|
|
|
|
|
E. Bell, R. J. Wingate, and A. Lumsden Homeotic Transformation of Rhombomere Identity After Localized Hoxb1 Misexpression Science, June 25, 1999; 284(5423): 2168 - 2171. [Abstract] [Full Text]
|
|
|
|
|
|
J. Barrow and M. Capecchi Compensatory defects associated with mutations in Hoxa1 restore normal palatogenesis to Hoxa2 mutants Development, January 11, 1999; 126(22): 5011 - 5026. [Abstract] [PDF]
|
|
|
|
|
|
R. Wingate and M. Hatten The role of the rhombic lip in avian cerebellum development Development, January 10, 1999; 126(20): 4395 - 4404. [Abstract] [PDF]
|
|
|
|
|
|
S Jungbluth, E Bell, and A Lumsden Specification of distinct motor neuron identities by the singular activities of individual Hox genes Development, January 6, 1999; 126(12): 2751 - 2758. [Abstract] [PDF]
|
|
|
|
|
|
M Maconochie, R Krishnamurthy, S Nonchev, P Meier, M Manzanares, P. Mitchell, and R Krumlauf Regulation of Hoxa2 in cranial neural crest cells involves members of the AP-2 family Development, January 4, 1999; 126(7): 1483 - 1494. [Abstract] [PDF]
|
|
|
|
|
|
F Helmbacher, C Pujades, C Desmarquet, M Frain, F. Rijli, P Chambon, and P Charnay Hoxa1 and Krox-20 synergize to control the development of rhombomere 3 Development, January 12, 1998; 125(23): 4739 - 4748. [Abstract] [PDF]
|
|
|
|
|
|
A Gavalas, M Studer, A Lumsden, F. Rijli, R Krumlauf, and P Chambon Hoxa1 and Hoxb1 synergize in patterning the hindbrain, cranial nerves and second pharyngeal arch Development, January 3, 1998; 125(6): 1123 - 1136. [Abstract] [PDF]
|
|
