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Development, Vol 124, Issue 19 3765-3777, Copyright © 1997 by Company of Biologists
JOURNAL ARTICLES |
A Stoykova, M Gotz, P Gruss and J Price
Department of Molecular Cell Biology, Max-Planck Institute for Biophysical Chemistry, Gottingen, Germany.
Mutations in the gene for the transcription factor, Pax6, induce marked developmental abnormalities in the CNS and the eye, but the cellular mechanisms that underlie the phenotype are unknown. We have examined the adhesive properties of cells from the developing forebrain in Small eye, the Pax6 mutant mouse. We have found that the segregation normally observed in aggregates of cortical and striatal cells in an in vitro assay is lost in Small eye. This correlates with an alteration of in vivo expression of the homophilic adhesion molecule, R-cadherin. Moreover, the boundary between cortical and striatal regions of the telencephalon is dramatically altered in Small eye: radial glial fascicles do not form at the border, and the normal expression of R-cadherin and tenascin-C at the border is lost. These data suggest a link between the transcription factor, Pax6, R-cadherin expression, cellular adhesion and boundary formation between developing forebrain regions.
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H Toresson, S. Potter, and K Campbell Genetic control of dorsal-ventral identity in the telencephalon: opposing roles for Pax6 and Gsh2 Development, January 10, 2000; 127(20): 4361 - 4371. [Abstract] [PDF]
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M. Duncan, Z Kozmik, K Cveklova, J Piatigorsky, and A Cvekl Overexpression of PAX6(5a) in lens fiber cells results in cataract and upregulation of (alpha)5(beta)1 integrin expression J. Cell Sci., January 9, 2000; 113(18): 3173 - 3185. [Abstract] [PDF]
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A Noveen, A Daniel, and V Hartenstein Early development of the Drosophila mushroom body: the roles of eyeless and dachshund Development, January 8, 2000; 127(16): 3475 - 3488. [Abstract] [PDF]
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E Matsunaga, I Araki, and H Nakamura Pax6 defines the di-mesencephalic boundary by repressing En1 and Pax2 Development, January 6, 2000; 127(11): 2357 - 2365. [Abstract] [PDF]
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N. Warren, D. Caric, T. Pratt, J. A. Clausen, P. Asavaritikrai, J. O. Mason, R. E. Hill, and D. J. Price The Transcription Factor, Pax6, is Required for Cell Proliferation and Differentiation in the Developing Cerebral Cortex Cereb Cortex, September 1, 1999; 9(6): 627 - 635. [Abstract] [Full Text] [PDF]
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P Chapouton, A Gartner, and M Gotz The role of Pax6 in restricting cell migration between developing cortex and basal ganglia Development, January 12, 1999; 126(24): 5569 - 5579. [Abstract] [PDF]
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I Araki and H Nakamura Engrailed defines the position of dorsal di-mesencephalic boundary by repressing diencephalic fate Development, January 11, 1999; 126(22): 5127 - 5135. [Abstract] [PDF]
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M Rhinn, A Dierich, M Le Meur, and S Ang Cell autonomous and non-cell autonomous functions of Otx2 in patterning the rostral brain Development, January 10, 1999; 126(19): 4295 - 4304. [Abstract] [PDF]
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K Hentges, K Thompson, and A Peterson The flat-top gene is required for the expansion and regionalization of the telencephalic primordium Development, January 4, 1999; 126(8): 1601 - 1609. [Abstract] [PDF]
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F Pituello, F Medevielle, F Foulquier, and A. Duprat Activation of Pax6 depends on somitogenesis in the chick embryo cervical spinal cord Development, January 2, 1999; 126(3): 587 - 596. [Abstract] [PDF]
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M Hallonet, T Hollemann, R Wehr, N. Jenkins, N. Copeland, T Pieler, and P Gruss Vax1 is a novel homeobox-containing gene expressed in the developing anterior ventral forebrain Development, January 7, 1998; 125(14): 2599 - 2610. [Abstract] [PDF]
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A. Fernandez, C Pieau, J Reperant, E Boncinelli, and M Wassef Expression of the Emx-1 and Dlx-1 homeobox genes define three molecularly distinct domains in the telencephalon of mouse, chick, turtle and frog embryos: implications for the evolution of telencephalic subdivisions in amniotes Development, January 6, 1998; 125(11): 2099 - 2111. [Abstract] [PDF]
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 Y. Shimoda, Y. Tajima, T. Osanai, A. Katsume, M. Kohara, T. Kudo, H. Narimatsu, N. Takashima, Y. Ishii, S. Nakamura, et al. Pax6 Controls the Expression of Lewis x Epitope in the Embryonic Forebrain by Regulating alpha 1,3-Fucosyltransferase IX Expression J. Biol. Chem., January 11, 2002; 277(3): 2033 - 2039. [Abstract] [Full Text] [PDF]
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J. M. Collinson, J. C. Quinn, M. A. Buchanan, M. H. Kaufman, S. E. Wedden, J. D. West, and R. E. Hill Primary defects in the lens underlie complex anterior segment abnormalities of the Pax6 heterozygous eye PNAS, August 14, 2001; 98(17): 9688 - 9693. [Abstract] [Full Text] [PDF]
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